ID Q8R6F7_FUSNN Unreviewed; 607 AA.
AC Q8R6F7;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=UDP-N-acetylglucosamine 4,6-dehydratase {ECO:0000313|EMBL:AAL93811.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:AAL93811.1};
DE EC=4.2.1.- {ECO:0000313|EMBL:AAL93811.1};
GN OrderedLocusNames=FN1696 {ECO:0000313|EMBL:AAL93811.1};
OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=190304 {ECO:0000313|EMBL:AAL93811.1, ECO:0000313|Proteomes:UP000002521};
RN [1] {ECO:0000313|EMBL:AAL93811.1, ECO:0000313|Proteomes:UP000002521}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 /
RC KCTC 2640 / LMG 13131 / VPI 4355 {ECO:0000313|Proteomes:UP000002521};
RX PubMed=11889109; DOI=10.1128/JB.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N., Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
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DR EMBL; AE009951; AAL93811.1; -; Genomic_DNA.
DR RefSeq; NP_602512.1; NC_003454.1.
DR AlphaFoldDB; Q8R6F7; -.
DR STRING; 190304.FN1696; -.
DR PaxDb; 190304-FN1696; -.
DR EnsemblBacteria; AAL93811; AAL93811; FN1696.
DR KEGG; fnu:FN1696; -.
DR PATRIC; fig|190304.8.peg.186; -.
DR eggNOG; COG1086; Bacteria.
DR HOGENOM; CLU_013560_5_2_0; -.
DR InParanoid; Q8R6F7; -.
DR BioCyc; FNUC190304:G1FZS-198-MONOMER; -.
DR Proteomes; UP000002521; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR Pfam; PF13727; CoA_binding_3; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AAL93811.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:AAL93811.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002521};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 282..561
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
SQ SEQUENCE 607 AA; 69122 MW; 9DB27F11F919CAB7 CRC64;
MGEIMNSIRK LVKFLIDIFL LNISLAISIF LKYDQIQITD RNINFFIYYN LSFCILYFIL
KIYNNSWRFS GISEYVALIT LSVSTTILSY ILRVFLKLST KSSLYFETFI IFTFLLIVSR
FLMFLTRMKG IIKKDLNQEN VLIYGAGESG VLLVKESRIN PNFPYKIVGF LDDNINKIGG
KVYGLRVFGG LDKVQEVVEK KDISKIIISM PSVSQNKVSN ILKEINKIEG LSVKILPNVD
NLIEEGNLTT QLRNIKLEDL LGRDEVKINT KEVFEFIQDK VIFVTGGGGS IGSELINQIA
KYNPKKIINI EINENASYLM ELELKRKYPY LDYKTEIASV RDFDKLDMLF NNYKPDILFH
AAAHKHVPLM ENNPEEAIKN NVFGTRNVAE CCLKYKLESV VLISTDKAVN PTNIMGATKR
VCEMIFQKYS ERSSETKFVA VRFGNVLGSN GSVIPIFSKL IEERKNLTLT HKDIIRYFMT
IPEAAQLVIE AATIGKGGEI LILDMGEPVK IYDLAKNMIK LSGSTVGIDI VGLRPGEKLF
EELLYDINSS EKTSNNKIFI TNMENEKVKV DIDDYYTILR DLIKENDIIG MRKTLASIIG
TFKGRVE
//
