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Database: UniProt
Entry: Q8R8M4
LinkDB: Q8R8M4
Original site: Q8R8M4 
ID   UVRB_THETN              Reviewed;         662 AA.
AC   Q8R8M4;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   01-OCT-2014, entry version 82.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204};
GN   OrderedLocusNames=TTE1971;
OS   Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC
OS   100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Caldanaerobacter.
OX   NCBI_TaxID=273068;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J.,
RA   Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L.,
RA   Tan H., Chen R., Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Contains 1 UVR domain. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
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DR   EMBL; AE008691; AAM25150.1; -; Genomic_DNA.
DR   RefSeq; NP_623546.1; NC_003869.1.
DR   ProteinModelPortal; Q8R8M4; -.
DR   SMR; Q8R8M4; 2-649.
DR   STRING; 273068.TTE1971; -.
DR   EnsemblBacteria; AAM25150; AAM25150; TTE1971.
DR   GeneID; 997167; -.
DR   KEGG; tte:TTE1971; -.
DR   PATRIC; 23898689; VBITheTen82880_1982.
DR   eggNOG; COG0556; -.
DR   HOGENOM; HOG000073580; -.
DR   KO; K03702; -.
DR   OMA; GDDWLIM; -.
DR   OrthoDB; EOG6B360R; -.
DR   BioCyc; CSUB273068:GJEB-3556-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.300; -; 4.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome;
KW   SOS response.
FT   CHAIN         1    662       UvrABC system protein B.
FT                                /FTId=PRO_0000138441.
FT   DOMAIN       25    412       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      429    595       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      620    655       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      38     45       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF        91    114       Beta-hairpin.
SQ   SEQUENCE   662 AA;  76403 MW;  53DC0FA140BB966F CRC64;
     MGGFKLVSNF KPTGDQPQAI EKLVEGVRRG YRYQTLLGVT GSGKTFTMAN IIARLNRPTL
     VIAHNKTLAA QLYSEFKEFF PENAVEYFVS YYDYYQPEAY VPETDTYIEK DASINEEIDK
     LRHSATAALF ERRDVIIVAS VSCIYGLGDP IDYENLMLSL RPGMVKDRDE IIRKLVEIQY
     ERNDINFTRG KFRVRGDVIE VFPASFSNKA IRIELFGDEI DRIAEIDVLT GEVLGYRKHV
     AIFPASHYAT SRDKLERAIK SIREELEERY KELKEMGKIV EAERLWQRTN YDLEMLQEMG
     YCKGIENYSR HISGRPPGSP PYTLLDYFPE DFLIFIDESH VTIPQLRGMY NGDRSRKEAL
     VEYGFRLPSA YDNRPLTFEE FEQRVNQVIF VSATPGPYEM EHSEQVVEQL IRPTGLVDPE
     VIVRPVKGQV DDLIAEIRKT VAKGYRVLVT TLTKKMAEDL SDYLKEMGIR VRYLHSDIET
     IERVEIIRDL RLGKFDVLIG INLLREGLDI PEVALVAILD ADKEGFLRSE TSLIQTIGRA
     ARNAEGRVIM YADTITNSMR RAIDETNRRR KIQMEYNEKH GIVPKTVVKG VRDVIQATQV
     AEKEEKYEKT ANFYDPDVIK STIEQLEKEM RQAAIELQFE KAAKLRDMIL ELRKQLEEVS
     LR
//
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