ID Q8S5P1_ORYSJ Unreviewed; 1245 AA.
AC Q8S5P1;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN OrderedLocusNames=LOC_Os10g25720 {ECO:0000313|EMBL:AAP53608.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947 {ECO:0000313|EMBL:AAP53608.1};
RN [1] {ECO:0000313|EMBL:AAP53608.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12791992; DOI=10.1126/science.1083523;
RG Rice Chromosome 10 Sequencing Consortium;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [2] {ECO:0000313|EMBL:AAP53608.1}
RP NUCLEOTIDE SEQUENCE.
RA Buell C.R., Wing R.A., McCombie W.R., Messing J., Yuan Q., Ouyang S.;
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAP53608.1}
RP NUCLEOTIDE SEQUENCE.
RA Buell R.;
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DP000086; AAP53608.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8S5P1; -.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR45835:SF87; RNA-DIRECTED DNA POLYMERASE; 1.
DR PANTHER; PTHR45835; YALI0A06105P; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF08284; RVP_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 160..175
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 413..592
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 945..1108
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 62..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1245 AA; 142301 MW; 988D5F99807F3DAC CRC64;
MTVTEYLHEF NRLARYAPED VRTDAEKQEK FLAGLDDELT NQLISGDYAN FERLVDKAIR
QEDQRNKMDR KRKAAQFRAP QGSHQRPRFA PGQQGGPTTM IVRQYRPFNP SNFPQGASGS
QNHHGGQPNR GAAPRPPTAP AQSGLSAQAK KETGAKPGSC FNCGELGHFA DKCPKPRRAG
PRFIQARVNH ASAEEAQAAP EVVLGTFPVN SIPATVLFDS GATHLFISKK FVGMHGLRKE
ELSTPMRVHA PGNSSTSVSF SPSVLIEIQR SPFLANLILL KSKDLDVILG MDWLTQFKGV
IDCANRTVTL TNEKGETVVY KSPDSPKQGV SLNQIEAEIP VVTVEKNLRK LEDIPIVCEY
PEVFPEDLTT MPPKREIEFR IDLAPGTAPI YKRPYRMAAN ELAEVKKQVD EQLQKGYIRP
STSPWGAPVI FVEKKDKTKR MCVDYRALNE VTIKNKYPLP RIDDLFDQLK GAKVFSKIDL
RSGYHQLRIR EEDIPKTAFT TRYGLYECTV MSFGLTNAPA FFMNLMNKVF MEFLDKFVVV
FIDDILIYSK SEEEHEQHLR LVLEKLKEHQ LYAKFSKCDF WLTEVKFLGH VITAQGVAVD
PSNVESVTKW TPPKTMSQIR SFLGLAGYYR RFIENFSRIA RPMTQLLKKD EKFKWTAECD
KSFEELKKKL VSAPVLILPD QMKDFQVYCD ASRHGLGCVL MQEGRVVAYA SRQLRPHEGN
YPTHDLELAA VVHALKIWRH YLIGNRCEVY TDHKSLKYIF TQPDLNLRQR RWLELIKDYD
MNIHYHPGKA NVVADALSRK SYCTALCIEG MCEKLQQELE RLNVGIVEHG FVAALEARPT
LVDQVRAAQV NDAEIAELKK NMRVGKARDF LEDEHGTIWL GERLCVPDDK ELKDLILTEA
HQTQYSIHPG STKIMRREIA EFVALCDVCQ RVKVEHQRPA GLLQPLQIPE WKWEEIGMDF
ITGLPRTSSG HDSIWVVVDR LTKVAHFIPV HTTYTSKRLA ELYLSRIMCL HGVPKKIVSD
RGSQFTSKFW QKLQEELGTR LNFSTAYHPQ TDGQTERVNQ ILEDMLRACA LDFGGAWDKN
LPYAEFSYNN SYQASLQMAP FEALYGRKCR TPLFWDQTGE RQLFGTEVLA EAEEKVRIIR
ERLRIAQSRQ KSYADNRRRE LTFEAGDYVY LRVTPLRGVH RFQTKGKLAA RFVGPYKILE
RRGEVAYQLE LPSNMIGIHD VFHVSQLKKC LRVPEEQAFS EHIDL
//
