ID   Q8SQJ2_ENCCU            Unreviewed;       659 AA.
AC   Q8SQJ2;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 3.
DT   22-FEB-2023, entry version 94.
DE   RecName: Full=Trehalase {ECO:0000256|RuleBase:RU361180};
DE            EC=3.2.1.28 {ECO:0000256|RuleBase:RU361180};
DE   AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN   OrderedLocusNames=ECU02_1370 {ECO:0000313|EMBL:CAD25166.3};
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813 {ECO:0000313|EMBL:CAD25166.3, ECO:0000313|Proteomes:UP000000819};
RN   [1] {ECO:0000313|EMBL:CAD25166.3, ECO:0000313|Proteomes:UP000000819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1 {ECO:0000313|EMBL:CAD25166.3,
RC   ECO:0000313|Proteomes:UP000000819};
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC         glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC         ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC         Evidence={ECO:0000256|ARBA:ARBA00001576,
CC         ECO:0000256|RuleBase:RU361180};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC       {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
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DR   EMBL; AL590442; CAD25166.3; -; Genomic_DNA.
DR   RefSeq; NP_584662.1; NM_001040851.1.
DR   AlphaFoldDB; Q8SQJ2; -.
DR   STRING; 284813.Q8SQJ2; -.
DR   CAZy; GH37; Glycoside Hydrolase Family 37.
DR   GeneID; 858652; -.
DR   KEGG; ecu:ECU02_1370; -.
DR   HOGENOM; CLU_006451_4_0_1; -.
DR   InParanoid; Q8SQJ2; -.
DR   OMA; DAPFGWA; -.
DR   OrthoDB; 1329212at2759; -.
DR   Proteomes; UP000000819; Chromosome II.
DR   GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR001661; Glyco_hydro_37.
DR   InterPro; IPR018232; Glyco_hydro_37_CS.
DR   PANTHER; PTHR23403; TREHALASE; 1.
DR   PANTHER; PTHR23403:SF1; TREHALASE; 1.
DR   Pfam; PF01204; Trehalase; 1.
DR   PRINTS; PR00744; GLHYDRLASE37.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR   PROSITE; PS00928; TREHALASE_2; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000819};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..659
FT                   /note="Trehalase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010546989"
FT   REGION          639..659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        640..659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   659 AA;  76692 MW;  7BFD686091CAA0C4 CRC64;
     MNFTWWMRWT LVPLTIHAAK RPSKMPRMDT NPCVSRKLLE AAFENKITKD SKYLVDKLFL
     KPPEEIDEML RSMESEGKFF RSEEDFWNFV GMHSIEPGSE FIFAKDNEEL EASMFSGVPE
     YVSRLEERLL EPNPQRESEG FKQSLETLVR VSKELNDAWK NLYVKQRDLD KGYYSTMIKV
     KNPFVIPGDR FKECYYWDTY WIIEGLVKSG MHKIAVGMVE NFILLIEKYG FIPNGTRTYY
     LNRTQPPYFC MMLFTVYRHV PWTEEVEEII KRGLKAAVME YNFFMNYRKE EIEKDGKSYV
     LNVYRVSDCT PRAESYSEDR KVAENNKSKD EVYRRREEDI YSNLKAGAES GWDYSSRWLG
     VRGELDSIRT SKRVPADLNA IMYANELIIM KLFEVVEGKR SKNAEDFKKK SEERYRAINA
     VLWSDEEGVW NDYDIEKKKH TSPGFYFSNL APMCYGISPP PDKNITVYDI LNAFAEEIFG
     HPGGMPASGS KNKNSPEQWD YPNVWPPLVH IMTFFLERIG ERQMALHLAR SLLENISVST
     SISDVTRRGI FEKYNCERVG DSGYKGEYAP QVGFGWTNGS AIHFLEHFSF ELASTKSHAV
     SYQEIKDLME KKVASREVPR KHTPENCLLL EDKLWDIESH SEGPNSSSGR PHPVVPTTV
//