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Database: UniProt
Entry: Q8SQK3_ENCCU
LinkDB: Q8SQK3_ENCCU
Original site: Q8SQK3_ENCCU 
ID   Q8SQK3_ENCCU            Unreviewed;       700 AA.
AC   Q8SQK3;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   07-JUN-2017, entry version 75.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=ECU09_1790 {ECO:0000313|EMBL:CAD27151.1};
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Microsporidia; Unikaryonidae; Encephalitozoon.
OX   NCBI_TaxID=284813 {ECO:0000313|EMBL:CAD27151.1, ECO:0000313|Proteomes:UP000000819};
RN   [1] {ECO:0000313|EMBL:CAD27151.1, ECO:0000313|Proteomes:UP000000819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1 {ECO:0000313|EMBL:CAD27151.1,
RC   ECO:0000313|Proteomes:UP000000819};
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M.,
RA   Weissenbach J., Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AL590451; CAD27151.1; -; Genomic_DNA.
DR   RefSeq; XP_955732.1; XM_950639.1.
DR   STRING; 284813.XP_955732.1; -.
DR   EnsemblFungi; CAD27151; CAD27151; CAD27151.
DR   GeneID; 860519; -.
DR   KEGG; ecu:ECU09_1790; -.
DR   EuPathDB; MicrosporidiaDB:ECU09_1790; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   HOGENOM; HOG000149163; -.
DR   InParanoid; Q8SQK3; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000000819; Chromosome IX.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000819};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000819};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    357    380       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    418       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    463    485       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    492    516       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    554    574       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    594    616       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    637    659       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   700 AA;  80782 MW;  FD7D9BB62373763D CRC64;
     MLRSEKMCLV SMYFSKDTAK QTIAEIGRNG LLHFRDLNKG IKSENLLYTR EIAHMEKLIS
     RMQYLTGGIG EIEEGVKHSD IDQVEEQVNK FFSRLIQLKS IKKETNTNQA RLKEDLYMQE
     ETENFLGTIT EEAHLVQFDF MTGIVEKGKK FLIRKVLHQA LRRNLVIRTK DVEDGIKTVF
     IVFAHGNEAL EKVKDIFSSL GGRIMDHKKF RECKRGLLEL SAAISQIQQI EDHNDEAIRK
     EQEKIRHFAN TWRYYLNKEM KIYQALNKLN FDFDRDCLVG EAWILGDEIG KLKRINELKG
     DGTSLFAFEI MESDEMPPTY FRTNAFTEPF QVLTNTYAVP SYGEINPAIF TLFTFPMLFG
     CMFGDVFHGL LLLFLSMYMI RNSKKFKNCS ETLRMVISGK YIIFAFSLGA MFFGLLYSDF
     GSLTIPLFSS SKDSGRTYPF GVDYMWHHSK NEMVFLNSMK MKMSIIIGFF HMSLGIAISF
     LNAIYFNEPL EIYGVLIPQT IIFCSFVGYM VFLIVYKWLV TSNYPSIIGV LVNMFTNPFI
     VAEEMYPYQL QVQLFLLFLI LLCIPWMLFG KPVYMMAKNM VKKEEISSLW INQFIHVVEF
     GLGLISNTSS YLRLWAVSLA HAQLTRVLHE FTIGKEGFIA PVALSGVYVL GTVVLLIGME
     GLGSCLHAMR LNWVEFHSKF FRGRGYLFEP LGFNLPLDDE
//
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