ID Q8SR47_ENCCU Unreviewed; 922 AA.
AC Q8SR47;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 22-FEB-2023, entry version 113.
DE SubName: Full=DNA MISMATCH REPAIR PROTEIN OF THE MUTS FAMILY {ECO:0000313|EMBL:CAD25790.1};
GN OrderedLocusNames=ECU10_0710 {ECO:0000313|EMBL:CAD25790.1};
OS Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC Encephalitozoon.
OX NCBI_TaxID=284813 {ECO:0000313|EMBL:CAD25790.1, ECO:0000313|Proteomes:UP000000819};
RN [1] {ECO:0000313|EMBL:CAD25790.1, ECO:0000313|Proteomes:UP000000819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GB-M1 {ECO:0000313|EMBL:CAD25790.1,
RC ECO:0000313|Proteomes:UP000000819};
RX PubMed=11719806; DOI=10.1038/35106579;
RA Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA Vivares C.P.;
RT "Genome sequence and gene compaction of the eukaryote parasite
RT Encephalitozoon cuniculi.";
RL Nature 414:450-453(2001).
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DR EMBL; AL590449; CAD25790.1; -; Genomic_DNA.
DR RefSeq; NP_586186.1; NM_001042019.1.
DR AlphaFoldDB; Q8SR47; -.
DR STRING; 284813.Q8SR47; -.
DR GeneID; 859835; -.
DR KEGG; ecu:ECU10_0710; -.
DR VEuPathDB; MicrosporidiaDB:ECU10_0710; -.
DR HOGENOM; CLU_002472_1_0_1; -.
DR InParanoid; Q8SR47; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000000819; Chromosome X.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03286; ABC_MSH6_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000819}.
FT DOMAIN 810..826
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 56..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 106136 MW; 381766502B7A5791 CRC64;
MKGKKTLFDY FDFSKKKEHS GEPSCRMSDV ENGVNEALSV DWEEAKRACR ALHPEHMGEE
DVGNEPVDLQ EDTQTQQASK SGRILMGDEE NERRRVEKEE RYRFLEDVRD RNGRRRGDEG
YDPSTLLIPE HEYKKFTPFE KQFWDIKKDF FDTIVFFKKG KFYELYENDA LVGARLFDLK
ITDRVNMKMS GFPEGSLDYW SRKFLEHGYK IARVEQSENM IGKQIRERDE MSKEGRVVKD
KIIRRELKEI ITQGTIYSID YMRSAMPMYL MSVATDEVCY SETCSGEVHT SVVLYDASIG
EVYFSSFCDD RSHHGIRTIL SQHDVKEMIA DFSIGGVPRV VPDKTACVSN RKYEFSNERE
YVCFQYLMRY MEKLRRADAL MNVKISRLQD EARTMGIDDA TLRNMEIFKN NYNGTDEKTL
FKAVDFCSTP FGQRLLRRWM MAPLVRKEDI VKRQEMALVF KRMDSTKLKE ALGRIGDGER
LLVRLYNGNP TAKDLSKFIR CLGACKETFD VLGMELRTRR LEGARDIVEK AEDYSCRIEE
VLVWHRKVYD VTEAGISPGE ENEDELCHLM SEKGKIEGDL DAYLQEQKTR LGCPSIRFRD
VGKDVFQMEV PKEIGVPSDY FIMSSVKGVN RYYSRDLRKL VERYMECEER IFQSKGSLLR
RAIDVLLPHV IFFRQVFCEL AQIDCYLSFA TFSQRNRTST PVFSTKLCFS GMSSPIYPAF
VENDYDGCRR ILVLTGANMG GKSTLLRTIC FNVILSQVGM DVCCKRMETP LFDRIFTRIG
ARDDLAKGES TFMIELGETS NILRHSTRDS LVIMDELGRG TSTKDGGCIA RAVLEYLKKK
ECHVLFSTHY HGIIGEVEGV SNGYMSSVIK GRDIVFLYKL VAGVSGDSHG LYVARMAGVP
DAIVERAEGI RKELLKSSVG RS
//
