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Database: UniProt
Entry: Q8SSS9
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ID   QKGA_DICDI              Reviewed;        1553 AA.
AC   Q8SSS9; Q557D4;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   14-MAY-2014, entry version 91.
DE   RecName: Full=Probable serine/threonine-protein kinase qkgA;
DE            EC=2.7.11.1;
DE   AltName: Full=Quick growth protein qkgA;
DE   AltName: Full=Ras of complex proteins and C-terminal of roc 2;
GN   Name=qkgA-1; Synonyms=roco2-1; ORFNames=DDB_G0273259;
GN   and
GN   Name=qkgA-2; Synonyms=roco2-2; ORFNames=DDB_G0273635;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14654223; DOI=10.1016/j.bbamcr.2003.08.008;
RA   Bosgraaf L., van Haastert P.J.M.;
RT   "Roc, a Ras/GTPase domain in complex proteins.";
RL   Biochim. Biophys. Acta 1643:5-10(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A.,
RA   Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G.,
RA   Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A.,
RA   Platzer M., Rosenthal A., Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [4]
RP   FUNCTION.
RX   PubMed=12954783; DOI=10.1093/nar/gng095;
RA   Abe T., Langenick J., Williams J.G.;
RT   "Rapid generation of gene disruption constructs by in vitro
RT   transposition and identification of a Dictyostelium protein kinase
RT   that regulates its rate of growth and development.";
RL   Nucleic Acids Res. 31:E107-E107(2003).
CC   -!- FUNCTION: Involved in growth, and during development, in
CC       aggregation.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. ROCO subfamily.
CC   -!- SIMILARITY: Contains 4 LRR (leucine-rich) repeats.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- SIMILARITY: Contains 1 Roc domain.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3
CC       and AX4. These strains contain a duplication of a segment of 750
CC       kb of chromosome 2 compared to the corresponding sequence in
CC       strain AX2.
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DR   EMBL; AY232265; AAO83648.1; -; Genomic_DNA.
DR   EMBL; AAFI02000011; EAL70508.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70847.1; -; Genomic_DNA.
DR   RefSeq; XP_644434.1; XM_639342.1.
DR   RefSeq; XP_644816.1; XM_639724.1.
DR   ProteinModelPortal; Q8SSS9; -.
DR   BioGrid; 1243921; 3.
DR   STRING; 44689.DDB_0185215; -.
DR   PRIDE; Q8SSS9; -.
DR   EnsemblProtists; DDB0185215; DDB0185215; DDB_G0273259.
DR   EnsemblProtists; DDB0304847; DDB0304847; DDB_G0273635.
DR   GeneID; 8618918; -.
DR   GeneID; 8619059; -.
DR   KEGG; ddi:DDB_G0273259; -.
DR   KEGG; ddi:DDB_G0273635; -.
DR   dictyBase; DDB_G0273259; qkgA-1.
DR   dictyBase; DDB_G0273635; qkgA-2.
DR   eggNOG; COG1100; -.
DR   OMA; IHESEKS; -.
DR   PhylomeDB; Q8SSS9; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031158; P:negative regulation of aggregate size involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IMP:dictyBase.
DR   GO; GO:0006997; P:nucleus organization; IMP:dictyBase.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IMP:dictyBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR013684; MIRO-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR020859; ROC_GTPase.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   Pfam; PF08477; Miro; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF56112; SSF56112; 2.
DR   PROSITE; PS51450; LRR; 3.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS51424; ROC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Leucine-rich repeat;
KW   Nucleotide-binding; Reference proteome; Repeat;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1   1553       Probable serine/threonine-protein kinase
FT                                qkgA.
FT                                /FTId=PRO_0000355208.
FT   REPEAT      287    309       LRR 1.
FT   REPEAT      311    333       LRR 2.
FT   REPEAT      334    356       LRR 3.
FT   REPEAT      357    378       LRR 4.
FT   DOMAIN      395    619       Roc.
FT   DOMAIN     1242   1546       Protein kinase.
FT   NP_BIND    1248   1256       ATP (By similarity).
FT   COMPBIAS    112    126       Poly-Ser.
FT   COMPBIAS    648    659       Poly-Ser.
FT   COMPBIAS    663    670       Poly-Ser.
FT   COMPBIAS    684    699       Poly-Gln.
FT   COMPBIAS    999   1004       Poly-Ser.
FT   COMPBIAS   1008   1018       Poly-Ser.
FT   COMPBIAS   1059   1081       Poly-Thr.
FT   COMPBIAS   1086   1089       Poly-Asn.
FT   COMPBIAS   1277   1295       Poly-Asn.
FT   COMPBIAS   1298   1301       Poly-Asn.
FT   ACT_SITE   1393   1393       Proton acceptor (By similarity).
FT   BINDING    1271   1271       ATP (By similarity).
SQ   SEQUENCE   1553 AA;  174817 MW;  734E5D777ADF1C0C CRC64;
     MDLEQDEWMS QRQRQQQMEF SRIGIEVIGS KKDLIVNSMK NHETTLTIIN ETYRIVYYDQ
     YESKFTSCNI ITFDGKDKRS IKKMKRVVQK LSNESTNSSH QFDLHSHALL QSSSSSSSSS
     TSSSPSLTSS PSSPISTSPP YHSSPQLLEH LLHQQQPITS VGSKPSFFVI INLYNDDRQS
     YMSEIVSFAG SFQFIEWRND ESWKEVFKLS SNLLTYHVKK NELARACTLG DINLLDEIIL
     SGCSKSQLKE AQGAGYTIVF NSYTSYSSGS SLVVSGTMAL LCAIVENGTF LLLSKSNITR
     FPMSIINMCS QLVELDMSNN RITEIPIEIT ELKFLKNLNL SDNLINDIPL EICNLTLLKV
     LLLNENPLNN FPSSIVELGT KKLLSFCRNI LEGKSCETWN KVKLMFVGEE GVGKTRLCKL
     LIGSKYNKKK SSSSSSSSLS SLSSALSSSS SSSSIINSNS ISNSNINMVN IKNENQVTGD
     TVSTEGVNIH DFKSKKVEFY AWDFGGQQIF YPTHQFFLTT QSLYLLIFRV NDSNFAERVN
     YWVHQIKAKS GISLPIIFFV GTHIDSCTPE QLSMAESILK SNFIKYSRVK QNVINFVSCV
     TGKGVKELKK RLIHESEKSR LIKKDIPGSY IILEQRLSNR GANQGRMSIS NSASNSSSSL
     LNSSSSSSPS LTSKKSSSHL KHSQQQQQQH QQQQQQLQQS IKEKYIDYDD YLNECKLSYL
     KPHEIKDATD FLHNLGIILH FDSPKLNNLV VLDPQWLADV MSSLITFSHS WIKLGILNHS
     DLQSIWGGRY KQTLWPSLLK LLEKFEVSYQ LPNLSKSLIP SLLPDDPIGE ILEIKDREWV
     PLKLAMENNY VQVFGCDYHF SFMPLGFFAR LLLRILLIQG IDIKTYWKDG VLLDILTPSD
     KIKQQQLLQK KSIFEPTTTL SPFLCSLSLT DSQNYSPLEP PPLILNSPRV NRKFISNSTS
     TTSTTTSTTS TSTTSSNNIT PLSMSSITPY SPTSPRTPSF SSSSTTTSSS SSSSSPSSQF
     CGVGCHRNIN KNNGSSNELI KTLTKINNQN GSSGELIKTT TTTSTSTSTT STTTPTTTTP
     TIPIKNNNNK KLPINRTVSS LCLTAKPKLQ ALITFIKKKS FEQSHDNDSY KLNIQVRTYN
     TTIDKEHSVS LFFQQLLFTI DTLISGSYQG LEVTRTIPCT HCIQLNPTIE PYHFDLGDCI
     SALEDGRSHV YCGNDPNTPV RIDYIAPDIC LKKVPTFTDD QILYERQIGE GGFGLIHKGK
     LISNKSDIAI KSLILCNSNN NNNSNNNNNS NNSNNFKNNN NEDEFIEKFQ EFQHEVFIMS
     NLNHPNIVKL YGLMHNPPRM VMEYVEHGDL YHLCQDKERY ASLGWTLKLR LMIDIAKGIG
     YMQNQNPPIV HRDLRSPNIF LKSLDENSPV CAKIADFGLS QQSVYSVSGL LGNFQWMAPE
     TIGVEDESYT EKVDTYSFAM ILFTILTGEI PFDEYSFGKM QFINLIREEN LRPTLPFDCD
     PRLSNLIQLC WSTNPKKRPS FTFIIKELLE IRIDSIQTSY FDSPFLKNYP ASI
//
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