ID Q8SZQ0_DROME Unreviewed; 225 AA.
AC Q8SZQ0;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2004, sequence version 2.
DT 24-JAN-2024, entry version 112.
DE RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
DE Flags: Fragment;
GN ORFNames=CG5757 {ECO:0000313|EMBL:AAL48064.2,
GN ECO:0000313|FlyBase:FBgn0034299};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAL48064.2};
RN [1] {ECO:0000313|EMBL:AAL48064.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Berkeley {ECO:0000313|EMBL:AAL48064.2};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
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DR EMBL; AY070593; AAL48064.2; -; mRNA.
DR AlphaFoldDB; Q8SZQ0; -.
DR EnsemblMetazoa; FBtr0329995; FBpp0303030; FBgn0034299.
DR AGR; FB:FBgn0034299; -.
DR FlyBase; FBgn0034299; CG5757.
DR VEuPathDB; VectorBase:FBgn0034299; -.
DR GeneTree; ENSGT00940000154030; -.
DR HOGENOM; CLU_049131_3_3_1; -.
DR OrthoDB; 5473102at2759; -.
DR PhylomeDB; Q8SZQ0; -.
DR Bgee; FBgn0034299; Expressed in egg chamber and 26 other cell types or tissues.
DR ExpressionAtlas; Q8SZQ0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:FlyBase.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IBA:GO_Central.
DR GO; GO:0004798; F:thymidylate kinase activity; ISS:FlyBase.
DR GO; GO:0009041; F:UMP/dUMP kinase activity; ISS:FlyBase.
DR GO; GO:0006233; P:dTDP biosynthetic process; ISS:FlyBase.
DR GO; GO:0006235; P:dTTP biosynthetic process; ISS:FlyBase.
DR GO; GO:0006227; P:dUDP biosynthetic process; ISS:FlyBase.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 26..205
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAL48064.2"
SQ SEQUENCE 225 AA; 25243 MW; 3A7ED5F0D98EF0A9 CRC64;
GRVANAGKCN IKIVMSAGKR GALIIFEGCD RSGKTTQSRL LVELLKSKGI PTLPMNFPER
SSSIGQVINS YLTNSKDLPD EVIHLMFSAN RWEHINQVKE KLLEGTTLVV DRYSFSGVAY
SAAKGLDFDW CYAPERGLIK PDAVFYLRAP PNDLTHRGQY GKERYEKVEF QGRVAEVFNR
ICSKEGSYFH QFDARQSVED LHAQIASITE ELLPKVATRP LDTLS
//
