GenomeNet

Database: UniProt
Entry: Q8TCH1_HUMAN
LinkDB: Q8TCH1_HUMAN
Original site: Q8TCH1_HUMAN 
ID   Q8TCH1_HUMAN            Unreviewed;        61 AA.
AC   Q8TCH1;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-SEP-2017, entry version 71.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
DE   Flags: Fragment;
GN   Name=TCIRG1 {ECO:0000313|EMBL:AAM18704.1,
GN   ECO:0000313|Ensembl:ENSP00000432957};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAM18704.1};
RN   [1] {ECO:0000313|EMBL:AAM18704.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Uterine cervix {ECO:0000313|EMBL:AAM18704.1};
RX   PubMed=12813892;
RA   Shulzhenko N., Smirnova A.S., Morgun A., Gerbase-DeLima M.;
RT   "Specificity of alternative splice form detection using RT-PCR with a
RT   primer spanning the exon junction.";
RL   BioTechniques 34:1244-1249(2003).
RN   [2] {ECO:0000313|EMBL:AAM18704.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Uterine cervix {ECO:0000313|EMBL:AAM18704.1};
RX   PubMed=15809087; DOI=10.1016/j.bbrc.2005.03.065;
RA   Smirnova A.S., Morgun A., Shulzhenko N., Silva I.D.,
RA   Gerbase-DeLima M.;
RT   "Identification of new alternative splice events in the TCIRG1 gene in
RT   different human tissues.";
RL   Biochem. Biophys. Res. Commun. 330:943-949(2005).
RN   [3] {ECO:0000313|Ensembl:ENSP00000432957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [4] {ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [5] {ECO:0000313|Ensembl:ENSP00000432957}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AP002807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF497545; AAM18704.1; -; mRNA.
DR   UniGene; Hs.495985; -.
DR   UniGene; Hs.716672; -.
DR   Ensembl; ENST00000530063; ENSP00000432957; ENSG00000110719.
DR   UCSC; uc058elu.1; human.
DR   EuPathDB; HostDB:ENSG00000110719.9; -.
DR   HGNC; HGNC:11647; TCIRG1.
DR   OpenTargets; ENSG00000110719; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   ChiTaRS; TCIRG1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110719; -.
DR   ExpressionAtlas; Q8TCH1; baseline and differential.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q8TCH1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AAM18704.1,
FT                                ECO:0000313|Ensembl:ENSP00000432957}.
SQ   SEQUENCE   61 AA;  6805 MW;  B5F91060BEFB3D01 CRC64;
     DDEEEAELVP SEVLMHQAIH TIEFCLGCVS NTASYLRLWA LSLAHARWNS RTSSTQARAT
     S
//
DBGET integrated database retrieval system