ID Q8TLG5_METAC Unreviewed; 667 AA.
AC Q8TLG5;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=Methyl-accepting chemotaxis protein {ECO:0000313|EMBL:AAM06444.1};
GN Name=mcp-1 {ECO:0000313|EMBL:AAM06444.1};
GN OrderedLocusNames=MA_3071 {ECO:0000313|EMBL:AAM06444.1};
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM06444.1, ECO:0000313|Proteomes:UP000002487};
RN [1] {ECO:0000313|EMBL:AAM06444.1, ECO:0000313|Proteomes:UP000002487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC {ECO:0000313|Proteomes:UP000002487};
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000256|ARBA:ARBA00029447}.
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DR EMBL; AE010299; AAM06444.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TLG5; -.
DR STRING; 188937.MA_3071; -.
DR EnsemblBacteria; AAM06444; AAM06444; MA_3071.
DR KEGG; mac:MA_3071; -.
DR HOGENOM; CLU_412592_0_0_2; -.
DR InParanoid; Q8TLG5; -.
DR PhylomeDB; Q8TLG5; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00283; MA; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002487};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW ProRule:PRU00284}.
FT DOMAIN 29..103
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 106..158
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 227..280
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 283..335
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 361..604
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000259|PROSITE:PS50111"
FT REGION 643..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 72959 MW; F93591A845A8A4A5 CRC64;
MQMSSIATDL ETTGQRNLSK NLVNDRGPEA KEVSSLIDNL PITVFRTSVD SSWAVRYISK
NVDVLTGHTK MDFISQKISW SDIVYPEDAP LIEEIVQKAM KNRTAYQVEY RIKKTDGSTV
FIQELAHLVN DDAGNLAYID GVFLDVTPQI LRREESQRAI VSSIPQPSLA LYVDASGKIK
YINDYFVKVC KFKKAEDAIG VSPTDLMESG DKKSLAEKVL ESGEAVYNLE RPLKLRALDK
PLHTVTSSVP IKDDSGAIIG NLTIITDMTE MKEKEKEIAE LLHYTNSCLK DLGEGIRRIG
EGDLEVHLEK IKDDDFGKTF EEFNQLVANL KSVIEIILAD MLTTLEEARQ SEEAVSQMNT
GMQQISTAAE QIATGSENLS RHAGTAATDV KASQDIFRKL SESSTKSSSY ASQAGKTSEE
AQELNNMALE GVEQFVAEIF KLGNIVHSLD DAVNNIGAVT GKIKSIADQT NLLALNAAIE
AARAGEYGRG FAVVADEVRK LAADSRKSTD EINEIVTNVQ KETKKVTEAI NAADIQAKTG
SKNIKQALNK SHEIAAAVAT INSMLLELDK LADDGLNKID NIEKSISEAA STAEENAASS
EETSAAIEEQ TAAMQQVSTS VQNVSELAQK TVDALIENFK VSGEQTNNQP SFGKPQHFDR
KKSTRMY
//
