ID Q8TLS7_METAC Unreviewed; 221 AA.
AC Q8TLS7;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Transcriptional regulator, TetR family {ECO:0000313|EMBL:AAM06325.1};
GN OrderedLocusNames=MA_2951 {ECO:0000313|EMBL:AAM06325.1};
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM06325.1, ECO:0000313|Proteomes:UP000002487};
RN [1] {ECO:0000313|EMBL:AAM06325.1, ECO:0000313|Proteomes:UP000002487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC {ECO:0000313|Proteomes:UP000002487};
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
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DR EMBL; AE010299; AAM06325.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TLS7; -.
DR STRING; 188937.MA_2951; -.
DR EnsemblBacteria; AAM06325; AAM06325; MA_2951.
DR KEGG; mac:MA_2951; -.
DR HOGENOM; CLU_069356_15_12_2; -.
DR InParanoid; Q8TLS7; -.
DR PhylomeDB; Q8TLS7; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR43479; ACREF/ENVCD OPERON REPRESSOR-RELATED; 1.
DR PANTHER; PTHR43479:SF7; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000002487}.
FT DOMAIN 13..73
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 36..55
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 221 AA; 25536 MW; 287559DA926E93E4 CRC64;
MIVLSKMLPE YREEAKKRIV EAGLEVMYEK GYCNTTMEDI ARRLDVSKPA LYRYFKNKDE
LVIESANYLQ TQYRDIKTTR NSDLCPVDSW IETFDQIMSP DIKIHALYFE ILGMTVRKPE
VQKRSVEGMK RGLDQPALEI AEQQRKGLIP SGADPRTLAV AIVSMFNGMR VLILLGVDWE
EVRSRWIEIL RNLFGMTGKG EQAECPRDCK WFEDCNTAPE A
//
