ID Q8TMY7_METAC Unreviewed; 1515 AA.
AC Q8TMY7;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Cell surface protein {ECO:0000313|EMBL:AAM05893.1};
GN OrderedLocusNames=MA_2507 {ECO:0000313|EMBL:AAM05893.1};
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM05893.1, ECO:0000313|Proteomes:UP000002487};
RN [1] {ECO:0000313|EMBL:AAM05893.1, ECO:0000313|Proteomes:UP000002487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC {ECO:0000313|Proteomes:UP000002487};
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
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DR EMBL; AE010299; AAM05893.1; -; Genomic_DNA.
DR RefSeq; WP_011022478.1; NC_003552.1.
DR STRING; 188937.MA_2507; -.
DR EnsemblBacteria; AAM05893; AAM05893; MA_2507.
DR GeneID; 1474396; -.
DR KEGG; mac:MA_2507; -.
DR HOGENOM; CLU_247986_0_0_2; -.
DR InParanoid; Q8TMY7; -.
DR OrthoDB; 137612at2157; -.
DR PhylomeDB; Q8TMY7; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02619; Peptidase_C1; 1.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 4.
DR InterPro; IPR006633; Carb-bd_sugar_hydrolysis-dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040528; Lectin-like.
DR InterPro; IPR007742; NosD_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR022441; Para_beta_helix_rpt-2.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR026453; PGF_pre_PGF.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR NCBIfam; TIGR03804; para_beta_helix; 8.
DR NCBIfam; TIGR04213; PGF_pre_PGF; 1.
DR PANTHER; PTHR22990; F-BOX ONLY PROTEIN; 1.
DR PANTHER; PTHR22990:SF15; F-BOX ONLY PROTEIN 10; 1.
DR Pfam; PF18560; Lectin_like; 1.
DR Pfam; PF05048; NosD; 2.
DR Pfam; PF00112; Peptidase_C1; 1.
DR Pfam; PF18911; PKD_4; 1.
DR SMART; SM00722; CASH; 2.
DR SMART; SM00710; PbH1; 20.
DR SMART; SM00645; Pept_C1; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 4.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002487}.
FT DOMAIN 526..596
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 1324..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1347
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1515 AA; 166977 MW; C64E73C6FC51D8A4 CRC64;
MRNMNITIRL LLSLILILGL AAAGSAEAEE SETVEQLTLT ANPVAEGSSG ADYSLAPVNP
EFLEYREQMD EMENIDDLIF SVRSSLTSET ESETEPEQKT VVHTTGLNPA PVDLSHLKAL
EDAEDSGSFE PFYDLRELGK VSPVKDQKDS GSCWAHGAYS SLESYLLPSE TWDFSENNMK
NLLTPYYPES FDYYEGGVTL MSVAYLTRWS GPVVETDDLY DSHSILSPDG LPTVKHVQEV
LFIPDRQGAL DNENIKRALQ EYGAVASTIY IDLAYFNSFN NSYYYPDEEF SNHLVAIVGW
DDSFDKNKFN PAAPGDGAFI VKNSWGSDWG DEGYFYVSYY DSKIGTDNAI YTAESLDDYD
SIYQYDPLGW VSSFGYAQKS FAWTANIFAA GENETLSAVS FYTTDSGAEY EVYIYTDPIS
GPINPKGPEA SEKGTFTCAG YHTVRLDQGV PLTKGQNFSV LLRFSAPEYG YPVALEYPID
GYSSQASSGA GESYVSPDGI SWVDLSSILE NSNACIKAFT DRDVAPEAAF VLNVTSGASP
LAVSFIDASR NSPSAWSWDF GDGSNSTEQN PVHSYSEEGL YTVTLSVENE FGANGTSRID
CVSVGKQAVI LYVDDDNVCG TSSNTYSSIQ EAVDRATAGS TIIVRDGWYS ETVNVDKPLT
IRSECGPEAT VVQSDKQEDS VFYVTADSVN ISGFFIIGAG DYSGSILSNC GILLYNVRGN
NICNNILTDN LLGICMYGSS DNTVQANNAI SNTHTGIYLY DSPNNTLFRN KAISNGYGIC
LRASGDNRLR RNEMVNNKYN LKITDFSSIN DIDKSNTVNR KSVYHIVGKS DLEINASFGA
GTVFCIDCQN VTVRDLALEN NYWGLVLCNT SNFLLENNTL EDNDIGMYLL DSGYGKIANN
SAVSNGDYGI LFENACENSV ENNTADSNKL YGLYLSSSWG NTLRNNTMSD NYFNFGAGGV
LEPNRIETNN LVDGKPIYFF VNRDGIELNS SSNAGTVYFV SCQNVSVRDL SLEYNLCGIY
LENTREARLE NNRVSDNLYG IYLENAEGGL LANNIASNND AGIFVLSSEN TTFEDNILSD
GGYGICLALS ENSSLLNNSA SDNFYGVYAY RSGNNTFTGN LANDNFEGIY LEASDNNRLI
NNYASENIYG LDLTFSSNNT LDTNTADLNY YGLSMWVSEN SSVNESNAGS NLIGILLWMS
EYNNLSNNTV LDNIYGFYLM DDSTGSGDKI RPNANTLVSN VVANNDGGIL IDESYGNLIY
RNYFNNTENV EDEYLNTWNS SEIGNYWSDY EGQDSNGDGI GDTPYVISNY TGSQDYLPVT
WLFDCPAQPE DNDSEGQDLE DDTDTSAEPA ENFWAVEASQ EDVSDSKIES ILGNSETGIT
EIVFEPWKYS TRIPSGYERF EEEASAIDSE QEDEPEDELD YAVSPGFEIS QSMNLLAGSE
EFENSGNINK AVIEFRVSKS WIEENNADIS TVVLKRFTDE SWTSFETAIA GEDGEYYFFE
AEIWDSPDIQ LRERK
//
