ID Q8TNC7_METAC Unreviewed; 443 AA.
AC Q8TNC7;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Phosphoesterase {ECO:0000313|EMBL:AAM05751.1};
GN OrderedLocusNames=MA_2363 {ECO:0000313|EMBL:AAM05751.1};
OS Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS C2A).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM05751.1, ECO:0000313|Proteomes:UP000002487};
RN [1] {ECO:0000313|EMBL:AAM05751.1, ECO:0000313|Proteomes:UP000002487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC {ECO:0000313|Proteomes:UP000002487};
RX PubMed=11932238; DOI=10.1101/gr.223902;
RA Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA Lander E., Metcalf W.W., Birren B.;
RT "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT physiological diversity.";
RL Genome Res. 12:532-542(2002).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE010299; AAM05751.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TNC7; -.
DR STRING; 188937.MA_2363; -.
DR EnsemblBacteria; AAM05751; AAM05751; MA_2363.
DR KEGG; mac:MA_2363; -.
DR HOGENOM; CLU_026621_4_0_2; -.
DR InParanoid; Q8TNC7; -.
DR PhylomeDB; Q8TNC7; -.
DR Proteomes; UP000002487; Chromosome.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0004529; F:DNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041796; Mre11_N.
DR InterPro; IPR014576; Pesterase_YhaO.
DR PANTHER; PTHR30337; COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE; 1.
DR PANTHER; PTHR30337:SF7; PHOSPHOESTERASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PIRSF; PIRSF033091; Pesterase_YhaO; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW Nuclease {ECO:0000256|ARBA:ARBA00022839};
KW Reference proteome {ECO:0000313|Proteomes:UP000002487}.
FT DOMAIN 23..222
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 443 AA; 49682 MW; D253394AAD4F16A8 CRC64;
MLGVPPMKKR ELSADTDRNG TLSFVHAADL HLDSPFVGIS GIDQELGERL AKATFQAYEA
IIELCMEEEV DFLLIAGDVY DSADKNLYAQ VRFIEGLRKL ETAGIQIFIC HGNHDPLDGW
SASLKWPANV HTMRGDKAEV VEFKKEGETA AFVVGMSYPT RHIMKNLVQD FPKKEDHWPF
TIGLLHCSVG SYPEHDPYAP CTLQDLREPG YDYWALGHIH TPSVVCKEAP VVIYPGNPQG
RHPGETGARG CCLVNVSSGG AISTKFVETD SVRWHIREIS IEGLEKEGEL VENLQSQLDE
IRENSGGRSA ICRLVLSGRG PLHLTLREEG FLEDLLHTLR EDEIRSRQFT WVERIENETL
FPIERELLLK REDFVGDLVK IVEGLKTDEE ALDEFHAVLA PLFKPGSGGK QICKIDDEEM
KSLLQCAENI LLDALLTEED HEN
//
