ID Q8TZW9_PYRFU Unreviewed; 505 AA.
AC Q8TZW9;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Trk system potassium uptake protein {ECO:0000313|EMBL:AAL81980.1};
GN OrderedLocusNames=PF1856 {ECO:0000313|EMBL:AAL81980.1};
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497 {ECO:0000313|EMBL:AAL81980.1, ECO:0000313|Proteomes:UP000001013};
RN [1] {ECO:0000313|EMBL:AAL81980.1, ECO:0000313|Proteomes:UP000001013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1
RC {ECO:0000313|Proteomes:UP000001013};
RX PubMed=10430560;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TrkH potassium transport family.
CC {ECO:0000256|ARBA:ARBA00009137}.
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DR EMBL; AE009950; AAL81980.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TZW9; -.
DR STRING; 186497.PF1856; -.
DR PaxDb; 186497-PF1856; -.
DR KEGG; pfu:PF1856; -.
DR PATRIC; fig|186497.12.peg.1927; -.
DR eggNOG; arCOG04145; Archaea.
DR HOGENOM; CLU_030708_3_0_2; -.
DR PhylomeDB; Q8TZW9; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR InterPro; IPR003445; Cat_transpt.
DR InterPro; IPR004772; TrkH.
DR NCBIfam; TIGR00933; 2a38; 1.
DR PANTHER; PTHR32024; TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED; 1.
DR PANTHER; PTHR32024:SF2; TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED; 1.
DR Pfam; PF02386; TrkH; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001013};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 505 AA; 56667 MW; A2FAE43730CE6A5D CRC64;
MFLFLTCKIG NRMVKLRTFI NISEDLFVIR NLIGAILQGI GLAYLVPVLL AWFYPEEIPL
VIYFAIPGFS CIILGWVLSK HMEKIEDVNL RQAMMASAFI WLFASLVSVI PFMGIAKMRF
VDSYFETMSA WTGTGLTMMS NLESYPKILL FWRAWMQWLG GIGIVLVALT VLIRPGVAAA
RLYKAEARSE RILPNFVNTA KIIVQIYAVL TLLGIYLYYS NGMSLFDATI HSMTGLGTGG
MSSHDLSIGY FNSLAIETVT VFLMIMGATN FTVHYRMFKN RSLKEFFRDI QVRYMLYFIT
LIVALMTYSL VFFGHLTPIR ALRESIFHAV SAITCTGFGI SNLAEYPEID KILLAILMVI
GGSAGSTSGG IKLIRIVLMY QSLKWTIEQA ILPKGAVIRK RVNGYEFTEE EIQEVLGFTM
TYIAFLLLGT LYIMLRLGVR FADALFEVAS AIGNVGLSVG ITSPLLPLDI KILLTILMWV
GRLEIFSTIV FIVGLAMIFS RRSKE
//
