ID Q8U0X7_PYRFU Unreviewed; 588 AA.
AC Q8U0X7;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN OrderedLocusNames=PF1454 {ECO:0000313|EMBL:AAL81578.1};
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497 {ECO:0000313|EMBL:AAL81578.1, ECO:0000313|Proteomes:UP000001013};
RN [1] {ECO:0000313|EMBL:AAL81578.1, ECO:0000313|Proteomes:UP000001013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1
RC {ECO:0000313|Proteomes:UP000001013};
RX PubMed=10430560;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AE009950; AAL81578.1; -; Genomic_DNA.
DR RefSeq; WP_011012601.1; NZ_CP023154.1.
DR AlphaFoldDB; Q8U0X7; -.
DR STRING; 186497.PF1454; -.
DR PaxDb; 186497-PF1454; -.
DR GeneID; 41713264; -.
DR KEGG; pfu:PF1454; -.
DR PATRIC; fig|186497.12.peg.1516; -.
DR eggNOG; arCOG00933; Archaea.
DR HOGENOM; CLU_023791_0_0_2; -.
DR OrthoDB; 49555at2157; -.
DR PhylomeDB; Q8U0X7; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR034471; GDGT/MA_synthase.
DR InterPro; IPR034474; Methyltransferase_Class_D.
DR InterPro; IPR000385; MoaA_NifB_PqqE_Fe-S-bd_CS.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR43306; 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43306:SF1; 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00385; 7_8-dihydro-6-hydroxymethylpte; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS01305; MOAA_NIFB_PQQE; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001013};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 135..348
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 588 AA; 68721 MW; DEF6C9A17274FA9B CRC64;
MAENLSAGEV PSGEKEFEAL TKRMREIIEF PEISEEEFEE MLKNANRGYG EPLPHRTYSL
CPESRRVVPA VVWEKDGMVW ITKKCPEGII TDLYSEDVDL YYRFLRWKFE DKKLFSVNVP
NTGINCPFDC GLCARHRSHT NLLNIVLTNR CNLSCWYCFF YAREGEPVYE PTLEQIRMML
RNAKKENPIG ANAVQFTGGE PTLRDDLIEI IKIAKEEGYD HVQLNTDGIR LAFEPELVKK
IREAGVNTLY LSYDGMTPQT NWKNHWEIPL IFENVRKAGG PGIVLVPTLI RNVNDHEAGA
IINFGLNHLD IVRGVNFQPI SLVGRVPKKE RQRFRITIAG AIKKIEEQTN GAISRDDWYP
IPIAGYIARF FEAFTGKHYY MTSHYACGAA TYVFLDKEEK KVIPIPRFID VEGFVEFLVE
KAEEIERARF KGLAKLKAIG ETVFIKFKQF YDEKYAPKGL DVLGLIKNAF MHGNYDALGQ
FHTKTLFLGM MHFMDEYNYD VERVERCVIH YAMPDGRIVP FCTFNVIPEI YRDKVQRQFS
YSWEEWKKLH PDWDYKKDKY FRTREFVEKM KNSELYRKTY IDIVNYFE
//
