ID Q8U2U0_PYRFU Unreviewed; 266 AA.
AC Q8U2U0;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Transcriptional regulatory protein, asnC family {ECO:0000313|EMBL:AAL80863.1};
GN OrderedLocusNames=PF0739 {ECO:0000313|EMBL:AAL80863.1};
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497 {ECO:0000313|EMBL:AAL80863.1, ECO:0000313|Proteomes:UP000001013};
RN [1] {ECO:0000313|EMBL:AAL80863.1, ECO:0000313|Proteomes:UP000001013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1
RC {ECO:0000313|Proteomes:UP000001013};
RX PubMed=10430560;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
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DR EMBL; AE009950; AAL80863.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8U2U0; -.
DR SMR; Q8U2U0; -.
DR STRING; 186497.PF0739; -.
DR PaxDb; 186497-PF0739; -.
DR KEGG; pfu:PF0739; -.
DR PATRIC; fig|186497.12.peg.780; -.
DR eggNOG; arCOG01585; Archaea.
DR HOGENOM; CLU_091233_4_0_2; -.
DR PhylomeDB; Q8U2U0; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR011017; TRASH_dom.
DR InterPro; IPR013603; TRASH_TR_C_arc.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30154; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR PANTHER; PTHR30154:SF36; TRANSCRIPTIONAL REGULATOR, ASNC FAMILY-RELATED; 1.
DR Pfam; PF08394; Arc_trans_TRASH; 1.
DR Pfam; PF13412; HTH_24; 1.
DR PRINTS; PR00033; HTHASNC.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00344; HTH_ASNC; 1.
DR SMART; SM00746; TRASH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00519; HTH_ASNC_1; 1.
DR PROSITE; PS50956; HTH_ASNC_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001013};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..126
FT /note="HTH asnC-type"
FT /evidence="ECO:0000259|PROSITE:PS50956"
SQ SEQUENCE 266 AA; 30991 MW; D484778DFBF67083 CRC64;
MVLTHIAHVI PLTLRVIFTF VTNIYFVTKL NGYYSCQNVN TNQMFFIFWQ LILPGNGGVG
MTKLDDLDLK LIYLLMDDAR LSISELADRL GVSRPTIRSR LEKLEKEGII QGYTIKLNPE
LQRAHNVVAL VVKTENPEKM DEFEEIIEIN RFTSTKYLIK VAVENMEDFR RVIEGTGVEV
IEIMPILETR EKKLKPKIKV PFKCDYCGKE IVGEPIVYKY HNKVYFFCCP TCFREFKKAR
ENLEKVKLPK EQKVKDAHEH EHHAHG
//
