ID Q8U4J7_PYRFU Unreviewed; 501 AA.
AC Q8U4J7;
DT 01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Icc related protein {ECO:0000313|EMBL:AAL80212.1};
GN OrderedLocusNames=PF0088 {ECO:0000313|EMBL:AAL80212.1};
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497 {ECO:0000313|EMBL:AAL80212.1, ECO:0000313|Proteomes:UP000001013};
RN [1] {ECO:0000313|EMBL:AAL80212.1, ECO:0000313|Proteomes:UP000001013}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1
RC {ECO:0000313|Proteomes:UP000001013};
RX PubMed=10430560;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
CC -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase class-
CC III family. {ECO:0000256|ARBA:ARBA00025742}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE009950; AAL80212.1; -; Genomic_DNA.
DR RefSeq; WP_011011200.1; NZ_CP023154.1.
DR AlphaFoldDB; Q8U4J7; -.
DR STRING; 186497.PF0088; -.
DR PaxDb; 186497-PF0088; -.
DR GeneID; 41711875; -.
DR KEGG; pfu:PF0088; -.
DR PATRIC; fig|186497.12.peg.92; -.
DR eggNOG; arCOG01153; Archaea.
DR HOGENOM; CLU_540399_0_0_2; -.
DR OrthoDB; 7513at2157; -.
DR PhylomeDB; Q8U4J7; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07400; MPP_1; 1.
DR Gene3D; 3.60.21.10; -; 2.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR42988:SF2; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CBUA0032-RELATED; 1.
DR PANTHER; PTHR42988; PHOSPHOHYDROLASE; 1.
DR Pfam; PF00149; Metallophos; 2.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Reference proteome {ECO:0000313|Proteomes:UP000001013}.
FT DOMAIN 1..184
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 269..432
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 501 AA; 57088 MW; 1522FE9EA7D73F2E CRC64;
MLIAHISDTH ITNEVAFKAY AFDLIVNEIN TRPFDLVIHT GDVTNNGLRE EYEHASYLLK
KIEKPLIVAP GNHDARNVGY ELFERYIGPL FGVYEFKDGV IIWVDSTIPD LSDGRIGGYK
FRWLKEKLEE YSNKKIKIAV AHHHLVPLPD TGRERNVLYN AGDVLDLLLS HDVTLYMCGH
KHVPNVYRVE DLVVANAGCT SCRKTRKGDV NSYNIVKISE KGVKVVIRRV TGEEKGKEHV
PIRPKIFVPR GRRIFRIVHL SESNVSDRKY FRKNVIENVV KAINEKYKPD LVIHCGDVVE
KGIERFFDMA IDYYESIKSE KLVIPGHNDY TYLGPELFRE YFGEPEIIEL NDFVFIPLIS
AQYETPIGVV GRIGQKMLAN LLEEYSEKFR VVVLHHNLVP IPRAKEIGYL EDAGNVLKII
TDANTELVLT GHGGNSHAVK VESTPLVNAG SVSWELHRNP FGNSFNIVDI YEDMIAVFEI
QATWGSRKLL GIWKIKGEVP W
//
