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Database: UniProt
Entry: Q8UIH5
LinkDB: Q8UIH5
Original site: Q8UIH5 
ID   UBIE_AGRT5              Reviewed;         259 AA.
AC   Q8UIH5;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   19-MAR-2014, entry version 81.
DE   RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE;
DE            EC=2.1.1.163;
DE            EC=2.1.1.201;
DE   AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE   AltName: Full=Demethylmenaquinone methyltransferase;
GN   Name=ubiE; OrderedLocusNames=Atu0320; ORFNames=AGR_C_559;
OS   Agrobacterium tumefaciens (strain C58 / ATCC 33970).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P.,
RA   Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L.,
RA   Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr.,
RA   Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C.,
RA   Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A.,
RA   Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D.,
RA   Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M.,
RA   Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M.,
RA   Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V.,
RA   Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M.,
RA   Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L.,
RA   Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F.,
RA   Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B.,
RA   Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G.,
RA   Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the
CC       conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
CC       2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC       methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC       trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC       methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC   -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC       menaquinone-2 from chorismate: step 8/8.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. UbiE family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK86136.2; Type=Erroneous initiation;
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DR   EMBL; AE007869; AAK86136.2; ALT_INIT; Genomic_DNA.
DR   PIR; AH2615; AH2615.
DR   PIR; G97397; G97397.
DR   RefSeq; NP_353351.2; NC_003062.2.
DR   ProteinModelPortal; Q8UIH5; -.
DR   STRING; 176299.Atu0320; -.
DR   EnsemblBacteria; AAK86136; AAK86136; Atu0320.
DR   GeneID; 1132358; -.
DR   KEGG; atu:Atu0320; -.
DR   PATRIC; 20810325; VBIAgrTum91616_0312.
DR   eggNOG; COG2226; -.
DR   HOGENOM; HOG000249463; -.
DR   KO; K03183; -.
DR   OMA; IWKRFTI; -.
DR   OrthoDB; EOG6M6JSB; -.
DR   ProtClustDB; PRK00216; -.
DR   UniPathway; UPA00079; UER00169.
DR   UniPathway; UPA00232; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01813; UbiE_methyltran; 1.
DR   InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR   InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR   Pfam; PF01209; Ubie_methyltran; 1.
DR   TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR   PROSITE; PS51608; SAM_MT_UBIE; 1.
DR   PROSITE; PS01183; UBIE_1; 1.
DR   PROSITE; PS01184; UBIE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase;
KW   Ubiquinone biosynthesis.
FT   CHAIN         1    259       Ubiquinone/menaquinone biosynthesis C-
FT                                methyltransferase UbiE.
FT                                /FTId=PRO_0000193235.
SQ   SEQUENCE   259 AA;  28862 MW;  4F017ED69E2C7FFB CRC64;
     MMTDARTTAE GGMETSYGFH KVDEGKKQGL VNEVFHKVAK RYDIMNDVMS AGLHRLWKDA
     MVSALSPRKD PSYKILDVAG GTGDVAFRII EASNRLAHAT VLDINGSMLA VGEERAAKKK
     LSDNLTFVEA NAEELPFEAN TFDAYTVAFG IRNVPRIDVA LKEAYRVLKR GGRLLVLEFS
     EVDMPLLDRV YDAWSFNAIP QFGKMITGDA EPYQYLVESI RKFPNQEDFA TMIRTAGFSR
     VTYTNYTGGI AALHSGWKL
//
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