ID UBIE_AGRT5 Reviewed; 259 AA.
AC Q8UIH5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 01-MAY-2013, entry version 73.
DE RecName: Full=Ubiquinone/menaquinone biosynthesis methyltransferase ubiE;
DE EC=2.1.1.163;
DE EC=2.1.1.201;
DE AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE AltName: Full=Demethylmenaquinone methyltransferase;
GN Name=ubiE; OrderedLocusNames=Atu0320; ORFNames=AGR_C_559;
OS Agrobacterium tumefaciens (strain C58 / ATCC 33970).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC Agrobacterium tumefaciens complex.
OX NCBI_TaxID=176299;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C58 / ATCC 33970;
RX PubMed=11743193; DOI=10.1126/science.1066804;
RA Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P.,
RA Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L.,
RA Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr.,
RA Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C.,
RA Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A.,
RA Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D.,
RA Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M.,
RA Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M.,
RA Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V.,
RA Nester E.W.;
RT "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT C58.";
RL Science 294:2317-2323(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C58 / ATCC 33970;
RX PubMed=11743194; DOI=10.1126/science.1066803;
RA Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M.,
RA Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L.,
RA Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F.,
RA Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B.,
RA Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G.,
RA Cielo C., Slater S.;
RT "Genome sequence of the plant pathogen and biotechnology agent
RT Agrobacterium tumefaciens C58.";
RL Science 294:2323-2328(2001).
CC -!- FUNCTION: Methyltransferase required for the conversion of
CC demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the
CC conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
CC 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC menaquinone-2 from chorismate: step 8/8.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiE
CC family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK86136.2; Type=Erroneous initiation;
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DR EMBL; AE007869; AAK86136.2; ALT_INIT; Genomic_DNA.
DR PIR; AH2615; AH2615.
DR PIR; G97397; G97397.
DR RefSeq; NP_353351.2; NC_003062.2.
DR ProteinModelPortal; Q8UIH5; -.
DR STRING; 176299.Atu0320; -.
DR GeneID; 1132358; -.
DR KEGG; atu:Atu0320; -.
DR PATRIC; 20810325; VBIAgrTum91616_0312.
DR eggNOG; COG2226; -.
DR HOGENOM; HOG000249463; -.
DR KO; K03183; -.
DR OMA; PYQYLVE; -.
DR ProtClustDB; PRK00216; -.
DR UniPathway; UPA00079; UER00169.
DR UniPathway; UPA00232; -.
DR GO; GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:HAMAP.
DR GO; GO:0009060; P:aerobic respiration; IEA:HAMAP.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01813; UbiE_methyltran; 1; -.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR InterPro; IPR025765; UbiE/COQ5_MeTrFase_dom.
DR PANTHER; PTHR10108:SF24; PTHR10108:SF24; 1.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS01183; UBIE_1; 1.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW Reference proteome; Transferase; Ubiquinone biosynthesis.
FT CHAIN 1 259 Ubiquinone/menaquinone biosynthesis
FT methyltransferase ubiE.
FT /FTId=PRO_0000193235.
SQ SEQUENCE 259 AA; 28862 MW; 4F017ED69E2C7FFB CRC64;
MMTDARTTAE GGMETSYGFH KVDEGKKQGL VNEVFHKVAK RYDIMNDVMS AGLHRLWKDA
MVSALSPRKD PSYKILDVAG GTGDVAFRII EASNRLAHAT VLDINGSMLA VGEERAAKKK
LSDNLTFVEA NAEELPFEAN TFDAYTVAFG IRNVPRIDVA LKEAYRVLKR GGRLLVLEFS
EVDMPLLDRV YDAWSFNAIP QFGKMITGDA EPYQYLVESI RKFPNQEDFA TMIRTAGFSR
VTYTNYTGGI AALHSGWKL
//
