ID Q8UWL6_TAKRU Unreviewed; 484 AA.
AC Q8UWL6; H2TIJ2;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Transcription factor SOX9 {ECO:0000313|EMBL:AAL32172.1, ECO:0000313|EMBL:AAQ18507.1};
DE SubName: Full=Transcription factor Sox-9 {ECO:0000313|Ensembl:ENSTRUP00000024494.3};
GN Name=SOX9 {ECO:0000313|EMBL:AAL32172.1};
GN Synonyms=LOC101064892 {ECO:0000313|Ensembl:ENSTRUP00000024494.3},
GN Sox9a {ECO:0000313|EMBL:AAQ18507.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:AAL32172.1};
RN [1] {ECO:0000313|EMBL:AAL32172.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11707075; DOI=10.1006/geno.2001.6648;
RA Bagheri-Fam S., Ferraz C., Demaille J., Scherer G., Pfeifer D.;
RT "Comparative genomics of the SOX9 region in human and Fugu rubripes:
RT conservation of short regulatory sequence elements within large intergenic
RT regions.";
RL Genomics 78:73-82(2001).
RN [2] {ECO:0000313|EMBL:AAQ18507.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15019997; DOI=10.1016/j.gene.2003.12.008;
RA Koopman P., Schepers G., Brenner S., Venkatesh B.;
RT "Origin and diversity of the SOX transcription factor gene family: genome-
RT wide analysis in Fugu rubripes.";
RL Gene 328:177-186(2004).
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000024494.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [4] {ECO:0000313|Ensembl:ENSTRUP00000024494.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AF329945; AAL32172.1; -; Genomic_DNA.
DR EMBL; AY277964; AAQ18507.1; -; Genomic_DNA.
DR RefSeq; XP_003979726.1; XM_003979677.2.
DR Ensembl; ENSTRUT00000024593.3; ENSTRUP00000024494.3; ENSTRUG00000009750.3.
DR GeneID; 101064892; -.
DR KEGG; tru:101064892; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000158269; -.
DR HOGENOM; CLU_916863_0_0_1; -.
DR OMA; QSSNSYY; -.
DR OrthoDB; 2902801at2759; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IEA:Ensembl.
DR GO; GO:0003170; P:heart valve development; IEA:Ensembl.
DR GO; GO:0061008; P:hepaticobiliary system development; IEA:Ensembl.
DR GO; GO:0050935; P:iridophore differentiation; IEA:Ensembl.
DR GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
DR GO; GO:0043049; P:otic placode formation; IEA:Ensembl.
DR GO; GO:0003342; P:proepicardium development; IEA:Ensembl.
DR GO; GO:0031099; P:regeneration; IEA:Ensembl.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0003309; P:type B pancreatic cell differentiation; IEA:Ensembl.
DR GO; GO:0061032; P:visceral serous pericardium development; IEA:Ensembl.
DR CDD; cd22031; HMG-box_SoxE; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022151; Sox_N.
DR PANTHER; PTHR45803; SOX100B; 1.
DR PANTHER; PTHR45803:SF1; TRANSCRIPTION FACTOR SOX-9; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12444; Sox_N; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 104..172
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 104..172
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 53459 MW; 083B48C4F2A9C859 CRC64;
MNLLDPYLKM TEEQEKCHSD APSPSMSEDS AGSPCPSGSG SDTENTRPSD NHLLLGPDYK
KENEEEKFPV CIRDAVSQVL KGYDWTLVPM PVRVNGSNKN KPHVKRPMNA FMVWAQAARR
KLADQYPHLH NAELSKTLGK LWRLLNEVEK RPFVEEAERL RVQHKKDHPD YKYQPRRRKS
VKNGQNDPED GEQTHISPNA IFKALQQADS PASSLGEVHS PGDHSGQSQG PPTPPTTPKT
DLVSSKADLK REGRPMQEGT SRQLNIDFGA VDIGELSSEV ISNMGSFDVD EFDQYLPPHS
HAGVSGAPQA GYTGSYGISS SSVSQAAGVG AQAWMSKQQQ QQQQQQQHSL TALSGGGEQS
QQGQQRPAQI KTEQLSPSHY SEQQGSPQHV TYGSFNLQHY STSSYPSMTR AQYDYSDHQG
GANSYYSHAA GQGSGLYSTF SYMNPSQRPM YTPIADNAGV PSVPQTHSPQ HWEQQPIYTQ
LSRP
//
