ID Q8V304_CAMPM Unreviewed; 242 AA.
AC Q8V304;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 24-JAN-2024, entry version 88.
DE RecName: Full=Host range factor p28 {ECO:0000256|ARBA:ARBA00039653};
DE AltName: Full=E3 ubiquitin-protein ligase p28 {ECO:0000256|ARBA:ARBA00034917};
OS Camelpox virus (strain M-96).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Camelpox virus.
OX NCBI_TaxID=203173 {ECO:0000313|EMBL:AAL73720.1, ECO:0000313|Proteomes:UP000152221};
OH NCBI_TaxID=9836; Camelus.
RN [1] {ECO:0000313|EMBL:AAL73720.1, ECO:0000313|Proteomes:UP000152221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12033760; DOI=10.1006/viro.2001.1343;
RA Afonso C.L., Tulman E.R., Lu Z., Zsak L., Sandybaev N.T., Kerembekova U.Z.,
RA Zaitsev V.L., Kutish G.F., Rock D.L.;
RT "The genome of camelpox virus.";
RL Virology 295:1-9(2002).
CC -!- FUNCTION: RING-finger E3 ubiquitin ligase which catalyzes the formation
CC of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Plays an
CC important role in virulence by acting as an anti-apoptotic factor.
CC {ECO:0000256|ARBA:ARBA00025051}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
CC -!- SIMILARITY: Belongs to the orthopoxvirus OPG021 family.
CC {ECO:0000256|ARBA:ARBA00034749}.
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DR EMBL; AF438165; AAL73720.1; -; Genomic_DNA.
DR RefSeq; NP_570403.1; NC_003391.1.
DR GeneID; 932686; -.
DR KEGG; vg:932686; -.
DR Proteomes; UP000152221; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0039648; P:modulation by symbiont of host protein ubiquitination; IEA:UniProtKB-KW.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016398; E3_ubiquitin-prot_ligase_p28.
DR InterPro; IPR018004; KilA/APSES_HTH.
DR InterPro; IPR017880; KilA_N.
DR InterPro; IPR045072; MKRN-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11224; MAKORIN-RELATED; 1.
DR PANTHER; PTHR11224:SF10; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF04383; KilA-N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR PIRSF; PIRSF003775; E3_ubiquit_lig_p28; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51301; KILA_N; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00023323};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW Modulation of host ubiquitin pathway by viral E3 ligase
KW {ECO:0000256|ARBA:ARBA00022711};
KW Modulation of host ubiquitin pathway by virus
KW {ECO:0000256|ARBA:ARBA00022662};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 21..131
FT /note="KilA-N"
FT /evidence="ECO:0000259|PROSITE:PS51301"
FT DOMAIN 173..226
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 242 AA; 28490 MW; 368DAA744D05051C CRC64;
MEFDPSKINI SSIDHVTILQ YIDEPNDIRL TVCIIQNINN ITYYINITKI NPHLANQFRA
WKKRIAGRDY MTNLSRDTGI QQSNLTETIR NCQKNRNIYG LYIHHNLVIN LVIDWITDVI
VQSIVRGLVN WYIDNNTYTP NTPNNTTTIS ELDIIKILDK YEDVYRVSKE KECGICYEAV
YSKRSENDRY FGLLDSCNHI FCITCINIWH RTRRETGASD NCPICRTRFR NITMSKFYKL
VN
//