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Database: UniProt
Entry: Q8VE11
LinkDB: Q8VE11
Original site: Q8VE11 
ID   MTMR6_MOUSE             Reviewed;         617 AA.
AC   Q8VE11;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-SEP-2014, entry version 98.
DE   RecName: Full=Myotubularin-related protein 6;
DE            EC=3.1.3.-;
GN   Name=Mtmr6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, and Embryonic head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-108, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Mast cell;
RX   PubMed=17947660; DOI=10.4049/jimmunol.179.9.5864;
RA   Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
RA   Kawakami T., Salomon A.R.;
RT   "Quantitative time-resolved phosphoproteomic analysis of mast cell
RT   signaling.";
RL   J. Immunol. 179:5864-5876(2007).
CC   -!- FUNCTION: Phosphatase that acts on lipids with a phosphoinositol
CC       headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel
CC       activity in CD4+ T-cells possibly by decreasing intracellular
CC       levels of phosphatidylinositol 3 phosphatase. Negatively regulates
CC       proliferation of reactivated CD4+ T-cells (By similarity).
CC   -!- SUBUNIT: Interacts with ALKBH4, KCNN4, MTMR7, MTMR8 and MTMR9 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope (By similarity).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Non-receptor class myotubularin subfamily.
CC   -!- SIMILARITY: Contains 1 myotubularin phosphatase domain.
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DR   EMBL; AK076218; BAC36259.1; -; mRNA.
DR   EMBL; AK154859; BAE32884.1; -; mRNA.
DR   EMBL; CH466535; EDL36118.1; -; Genomic_DNA.
DR   EMBL; BC020019; AAH20019.1; -; mRNA.
DR   CCDS; CCDS27176.1; -.
DR   RefSeq; NP_659092.1; NM_144843.4.
DR   UniGene; Mm.247007; -.
DR   ProteinModelPortal; Q8VE11; -.
DR   SMR; Q8VE11; 4-505.
DR   STRING; 10090.ENSMUSP00000022563; -.
DR   PhosphoSite; Q8VE11; -.
DR   MaxQB; Q8VE11; -.
DR   PaxDb; Q8VE11; -.
DR   PRIDE; Q8VE11; -.
DR   DNASU; 219135; -.
DR   Ensembl; ENSMUST00000022563; ENSMUSP00000022563; ENSMUSG00000021987.
DR   GeneID; 219135; -.
DR   KEGG; mmu:219135; -.
DR   UCSC; uc007ufa.2; mouse.
DR   CTD; 9107; -.
DR   MGI; MGI:2145637; Mtmr6.
DR   eggNOG; NOG322789; -.
DR   GeneTree; ENSGT00710000106694; -.
DR   HOGENOM; HOG000210599; -.
DR   HOVERGEN; HBG000220; -.
DR   InParanoid; Q8VE11; -.
DR   KO; K18083; -.
DR   OMA; VFNIIMN; -.
DR   OrthoDB; EOG71RXJC; -.
DR   PhylomeDB; Q8VE11; -.
DR   TreeFam; TF315197; -.
DR   Reactome; REACT_198973; Synthesis of PIPs at the plasma membrane.
DR   ChiTaRS; MTMR6; mouse.
DR   NextBio; 376593; -.
DR   PRO; PR:Q8VE11; -.
DR   Bgee; Q8VE11; -.
DR   Genevestigator; Q8VE11; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:Ensembl.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR011993; PH_like_dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Hydrolase; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN         1    617       Myotubularin-related protein 6.
FT                                /FTId=PRO_0000367041.
FT   DOMAIN      124    499       Myotubularin phosphatase.
FT   REGION      248    251       Substrate binding (By similarity).
FT   REGION      273    274       Substrate binding (By similarity).
FT   REGION      336    342       Substrate binding (By similarity).
FT   ACT_SITE    336    336       Phosphocysteine intermediate (By
FT                                similarity).
FT   BINDING     382    382       Substrate (By similarity).
FT   MOD_RES     108    108       Phosphotyrosine.
FT   MOD_RES     557    557       Phosphoserine (By similarity).
FT   MOD_RES     585    585       Phosphoserine (By similarity).
SQ   SEQUENCE   617 AA;  70933 MW;  EE699C578602A013 CRC64;
     MEHIRTTKVE QVKLLDRFST NNKSLTGTLY LTATHLLFID AQQKETWILH HHIASVEKLA
     LTTSGCPLVI QCKNFRIVHF IVPRERDCHD IYNSLLQLSK QAKYEDLYAF SYNPKQNDTE
     RRNGWQLIDL AAEYERMGVP NANWQLSDAN REYKVCETYP RELYVPRTAS RPVIVGSSNF
     RSKGRLPVLS YCRQGTEAAI CRCSQPLSGF SARCLEDEHL LQAISKANPG NRYMYVVDTR
     PKLNAIANRA AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGS KGLSVNDFYS
     GLESSGWLRH IKAVLDAAIF LAKAIVVENA SVLVHCSDGW DRTSQVCSLG SLLLDSYYRT
     MKGFMVLIEK DWISFGHKFS ERCGHLDGDP REVSPVFTQF LECVWHLTQQ FPQAFEFNEA
     FLLQIHEHIH SCQFGNFLGN CQKEREELRL KEKTYSLWPF LLDDKKKYLN PLYSSKSQRL
     TVLEPNTASF NFKFWRNMYH QFDRTLHPRQ SVLSIIMNMN EQSKQLEEDI KDLEAKIKQC
     KNGILTKELL HAVHPESPAL KTSLCLKEPS LLPVKDTLRA IEGSSPADNR YCDYAEEFSK
     SEPTVVSLEY GVARMTC
//
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