ID Q8WQF3_CAEEL Unreviewed; 368 AA.
AC Q8WQF3;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 2.
DT 27-MAR-2024, entry version 137.
DE SubName: Full=UPF3 domain-containing protein {ECO:0000313|EMBL:CAD18872.2};
GN Name=smg-4 {ECO:0000313|EMBL:CAD18872.2,
GN ECO:0000313|WormBase:F46B6.3b};
GN ORFNames=CELE_F46B6.3 {ECO:0000313|EMBL:CAD18872.2}, F46B6.3
GN {ECO:0000313|WormBase:F46B6.3b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD18872.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAD18872.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD18872.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the RENT3 family.
CC {ECO:0000256|ARBA:ARBA00005991}.
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DR EMBL; BX284605; CAD18872.2; -; Genomic_DNA.
DR RefSeq; NP_741600.1; NM_171514.4.
DR AlphaFoldDB; Q8WQF3; -.
DR SMR; Q8WQF3; -.
DR STRING; 6239.F46B6.3b.1; -.
DR EPD; Q8WQF3; -.
DR PaxDb; 6239-F46B6-3b; -.
DR EnsemblMetazoa; F46B6.3b.1; F46B6.3b.1; WBGene00004882.
DR GeneID; 179371; -.
DR KEGG; cel:CELE_F46B6.3; -.
DR AGR; WB:WBGene00004882; -.
DR WormBase; F46B6.3b; CE30440; WBGene00004882; smg-4.
DR eggNOG; KOG1295; Eukaryota.
DR GeneTree; ENSGT00390000017146; -.
DR InParanoid; Q8WQF3; -.
DR OMA; KYMTEHE; -.
DR OrthoDB; 5490773at2759; -.
DR Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72187; mRNA 3'-end processing.
DR Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00004882; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; Q8WQF3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:WormBase.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0030539; P:male genitalia development; IMP:WormBase.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IMP:WormBase.
DR GO; GO:0045727; P:positive regulation of translation; IBA:GO_Central.
DR CDD; cd12455; RRM_like_Smg4_UPF3; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039722; Upf3.
DR InterPro; IPR005120; UPF3_dom.
DR PANTHER; PTHR13112:SF0; FI21285P1; 1.
DR PANTHER; PTHR13112; UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN; 1.
DR Pfam; PF03467; Smg4_UPF3; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q8WQF3,
KW ECO:0007829|PeptideAtlas:Q8WQF3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 8..172
FT /note="UPF3"
FT /evidence="ECO:0000259|Pfam:PF03467"
FT REGION 178..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 368 AA; 43149 MW; B8F1341FB87855E6 CRC64;
MTDSKDGHVK VVLRRLPKYM TEHEVLEQIS PLPEEVIGTY FHPANFSFDR CAYATLTVNF
SEYCDSMMEF ERRFDGYIFV DSRGNDSAAV VEAASNQNFA KCDRNRMKED TRVGAILTDK
YYLDFCKKLE EERAIPILTL EQQIRKLNQP DDARTQIDKM ETPLVKYFFE KETGKRRDYD
ARRQRRDEKR AEKRDKVDKF EKHKNVLDIL MKPSVPMAST SATTSKKDLK KEKPMTEKEK
ERWEKQDAKR KERNMIRKQK FLDEKKKKHE EREQDGPRVP RDKKKERLAK PPRPSPAKTV
GEQQGEDWIK KLTDPKSAPM KKKHDLSVTT KLNKETDTRP RTAPSSTKLP TRATTSNHPK
RPSTAPNH
//
