ID Q8WQX8_BIOGL Unreviewed; 655 AA.
AC Q8WQX8;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Fibrinogen-related protein 3-2 {ECO:0000313|EMBL:AAK28656.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EMBL:AAK28656.1};
RN [1] {ECO:0000313|EMBL:AAK28656.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M-line {ECO:0000313|EMBL:AAK28656.1};
RX PubMed=9238039; DOI=10.1073/pnas.94.16.8691;
RA Adema C.M., Hertel L.A., Miller R.D., Loker E.S.;
RT "A family of fibrinogen-related proteins that precipitates parasite-derived
RT molecules is produced by an invertebrate after infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:8691-8696(1997).
RN [2] {ECO:0000313|EMBL:AAK28656.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M-line {ECO:0000313|EMBL:AAK28656.1};
RA Leonard P.M., Adema C.M., Zhang S.-M., Loker E.S.;
RT "Structure of two FREP genes that combine IgSF and fibrinogen domains, with
RT comments on diversity of the FREP gene family in the snail Biomphalaria
RT glabrata.";
RL Gene 0:0-0(2001).
RN [3] {ECO:0000313|EMBL:AAK28656.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M-line {ECO:0000313|EMBL:AAK28656.1};
RX PubMed=11797103; DOI=10.1007/s00251-001-0386-8;
RA Zhang S.M., Leonard P.M., Adema C.M., Loker E.S.;
RT "Parasite-responsive IgSF members in the snail Biomphalaria glabrata:
RT characterization of novel genes with tandemly arranged IgSF domains and a
RT fibrinogen domain.";
RL Immunogenetics 53:684-694(2001).
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DR EMBL; AY028461; AAK28656.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8WQX8; -.
DR VEuPathDB; VectorBase:BGLB000096; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR19143:SF327; FI21813P1-RELATED; 1.
DR PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..655
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004315718"
FT DOMAIN 447..655
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT COILED 319..353
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 655 AA; 75229 MW; 6C75D45E379E0096 CRC64;
MARLFLLFIL CVFVVSLAGS ELVIDVQPNV ISPEITPQLV INCSITNNEV QTLDLIKSLT
LSRYNETIRE FDELIALDSL TLNLKQFVRF KYSQISFGNR YITLILHNPT QFDARIYKCN
ATGTNSEGAN ISLFAKKAVE YETNSTALIE EIRRIKKDEN YCSFKKDDLS DSKQRSRVYF
SGSSDIIKER IEPLTLKCTF QVLKTDQNET SRLQSLYILH ESKGVIAYVN KDQPVVTSLQ
GSNIQDVEGE IYDNAIKDSY LQVTWSNLKH SESGKYFCEA HNKYSEGRID KSSNMLTITV
ERPTFDDLVE AMHKLFTQVD GAKESLKAIN QNIKNINKDL DFKEQNITSI KQEVIRNQNN
IQILSEDLNI KEQNLTSIKA DLSTKQQTFL NIKEDVILNQ QIIHKIKQDL NTYRHNMSNI
EEHLEVILTN LSTASIKVKN QTDEGSKMSY PPRKSCRDVN STDERVVVTL TSGLKVMCDT
KTDGGGWIIF QRRINGNVDF YRGWKEYRDG FGDYNIGEFY LGNENIYMLT STGQYNLRID
LKYKNKAFFA QYSGFKILSE KEKYKLNIGA YSGNSGDNFS SHNNAFFTTF DRDNDEYSYN
CAVDYTGAWW YHSSCLNCNL NGKWGSSDFA KGVNWYDLSR FDSSVSFTEM KIREI
//
