ID Q8WRH7_9HYME Unreviewed; 375 AA.
AC Q8WRH7;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Elongation factor 1-alpha {ECO:0000256|RuleBase:RU000325};
DE Flags: Fragment;
OS Rhinetula denticrus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Halictidae; Halictinae; Halictini; Rhinetula.
OX NCBI_TaxID=178064 {ECO:0000313|EMBL:AAL40785.1};
RN [1] {ECO:0000313|EMBL:AAL40785.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11782550; DOI=10.1073/pnas.012387999;
RA Danforth B.N.;
RT "Evolution of sociality in a primitively eusocial lineage of bees.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:286-290(2002).
RN [2] {ECO:0000313|EMBL:AAL40785.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17015826; DOI=10.1073/pnas.0604033103;
RA Danforth B.N., Sipes S., Fang J., Brady S.G.;
RT "The history of early bee diversification based on five genes plus
RT morphology.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15118-15123(2006).
RN [3] {ECO:0000313|EMBL:AAL40785.1}
RP NUCLEOTIDE SEQUENCE.
RA Danforth B.N., Eardley C., Packer L., Walker K., Pauly A.,
RA Randrianambinintsoa F.J.;
RT "Phylogeny of Halictidae with an emphasis on endemic African Halictinae.";
RL Apidologie 39:86-101(2008).
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003982, ECO:0000256|RuleBase:RU000325}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249,
CC ECO:0000256|RuleBase:RU000325}.
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DR EMBL; AF435405; AAL40785.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8WRH7; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR NCBIfam; TIGR00483; EF-1_alpha; 1.
DR PANTHER; PTHR23115:SF170; ELONGATION FACTOR 1-ALPHA 2; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:AAL40785.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000325};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000325};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:AAL40785.1}.
FT DOMAIN 1..194
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAL40785.1"
FT NON_TER 375
FT /evidence="ECO:0000313|EMBL:AAL40785.1"
SQ SEQUENCE 375 AA; 40848 MW; 931EFED34C25511B CRC64;
MGKGSFKYAW VLDKLKAERE RGITIDIALW KFETSKYYVT IIDAPGHRDF IKNMITGTSQ
ADCAVLIVAA GTGEFEAGIS KNGQTREHAL LAFTLGVKQL IVGVNKMDST EPPYSEARFE
EIKKEVSSYI KKIGYNPAAV AFVPISGWHG DNMLEISSKM PWFKGWAVER KEGKAEGKCL
IEALDAILPP TRPTDKALRL PLQDVYKIGG IGTVPVGRVE TGVLKPGMLV TFAPAGLTTE
VKSVEMHHEA LTEAVPGDNV GFNVKNVAVK ELRRGYVAGD SKNNPPKGAA DFTAQVIVLN
HPGQISNGYT PVLDCHTAHI ACKFYKIIEK CDRRTGKTTE MDPKAIKSGD AAIVTLVPSK
AMCVEAFQEF PPLGR
//
