ID ASB13_HUMAN Reviewed; 278 AA.
AC Q8WXK3; A8K7Q6; D3DRR2; Q96EP7; Q9H8Z1;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2002, sequence version 2.
DT 27-MAR-2024, entry version 182.
DE RecName: Full=Ankyrin repeat and SOCS box protein 13;
DE Short=ASB-13;
GN Name=ASB13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Kile B.T., Nicola N.A.;
RT "SOCS box proteins.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Stomach;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- INTERACTION:
CC Q8WXK3; P54253: ATXN1; NbExp=6; IntAct=EBI-707573, EBI-930964;
CC Q8WXK3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-707573, EBI-10976677;
CC Q8WXK3; O14901: KLF11; NbExp=3; IntAct=EBI-707573, EBI-948266;
CC Q8WXK3; P27448: MARK3; NbExp=2; IntAct=EBI-707573, EBI-707595;
CC Q8WXK3; Q9BZ23-2: PANK2; NbExp=3; IntAct=EBI-707573, EBI-25929070;
CC Q8WXK3; O60260-5: PRKN; NbExp=3; IntAct=EBI-707573, EBI-21251460;
CC Q8WXK3; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-707573, EBI-396669;
CC Q8WXK3; P37840: SNCA; NbExp=3; IntAct=EBI-707573, EBI-985879;
CC Q8WXK3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-707573, EBI-5235340;
CC Q8WXK3; Q13148: TARDBP; NbExp=3; IntAct=EBI-707573, EBI-372899;
CC Q8WXK3; Q08AM6: VAC14; NbExp=6; IntAct=EBI-707573, EBI-2107455;
CC Q8WXK3; P40337-2: VHL; NbExp=3; IntAct=EBI-707573, EBI-12157263;
CC Q8WXK3; Q8NF64-2: ZMIZ2; NbExp=3; IntAct=EBI-707573, EBI-10182121;
CC Q8WXK3-2; Q96DX5: ASB9; NbExp=3; IntAct=EBI-12015080, EBI-745641;
CC Q8WXK3-2; Q86V38: ATN1; NbExp=3; IntAct=EBI-12015080, EBI-11954292;
CC Q8WXK3-2; P00488: F13A1; NbExp=3; IntAct=EBI-12015080, EBI-2565863;
CC Q8WXK3-2; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-12015080, EBI-11956675;
CC Q8WXK3-2; Q92876: KLK6; NbExp=3; IntAct=EBI-12015080, EBI-2432309;
CC Q8WXK3-2; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-12015080, EBI-1052037;
CC Q8WXK3-2; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-12015080, EBI-11992140;
CC Q8WXK3-2; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-12015080, EBI-10699187;
CC Q8WXK3-2; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-12015080, EBI-12813389;
CC Q8WXK3-2; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-12015080, EBI-1389308;
CC Q8WXK3-2; P78424: POU6F2; NbExp=3; IntAct=EBI-12015080, EBI-12029004;
CC Q8WXK3-2; O60260-5: PRKN; NbExp=3; IntAct=EBI-12015080, EBI-21251460;
CC Q8WXK3-2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-12015080, EBI-5235340;
CC Q8WXK3-2; Q15645: TRIP13; NbExp=3; IntAct=EBI-12015080, EBI-358993;
CC Q8WXK3-2; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-12015080, EBI-2514383;
CC Q8WXK3-2; Q08AM6: VAC14; NbExp=3; IntAct=EBI-12015080, EBI-2107455;
CC Q8WXK3-2; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-12015080, EBI-745520;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WXK3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WXK3-2; Sequence=VSP_000272, VSP_000273;
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL57350.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF403031; AAL57350.1; ALT_FRAME; mRNA.
DR EMBL; AK023196; BAB14456.1; -; mRNA.
DR EMBL; AK292071; BAF84760.1; -; mRNA.
DR EMBL; CR457302; CAG33583.1; -; mRNA.
DR EMBL; AL365356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW86435.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86436.1; -; Genomic_DNA.
DR EMBL; BC012056; AAH12056.1; -; mRNA.
DR CCDS; CCDS7070.1; -. [Q8WXK3-1]
DR RefSeq; NP_078977.2; NM_024701.3. [Q8WXK3-1]
DR AlphaFoldDB; Q8WXK3; -.
DR SMR; Q8WXK3; -.
DR BioGRID; 122865; 34.
DR IntAct; Q8WXK3; 32.
DR MINT; Q8WXK3; -.
DR STRING; 9606.ENSP00000350331; -.
DR iPTMnet; Q8WXK3; -.
DR PhosphoSitePlus; Q8WXK3; -.
DR BioMuta; ASB13; -.
DR DMDM; 20531995; -.
DR EPD; Q8WXK3; -.
DR MassIVE; Q8WXK3; -.
DR MaxQB; Q8WXK3; -.
DR PaxDb; 9606-ENSP00000350331; -.
DR PeptideAtlas; Q8WXK3; -.
DR ProteomicsDB; 75073; -. [Q8WXK3-1]
DR ProteomicsDB; 75074; -. [Q8WXK3-2]
DR Pumba; Q8WXK3; -.
DR Antibodypedia; 24111; 165 antibodies from 19 providers.
DR DNASU; 79754; -.
DR Ensembl; ENST00000357700.11; ENSP00000350331.6; ENSG00000196372.13. [Q8WXK3-1]
DR Ensembl; ENST00000459912.5; ENSP00000433358.1; ENSG00000196372.13. [Q8WXK3-2]
DR GeneID; 79754; -.
DR KEGG; hsa:79754; -.
DR MANE-Select; ENST00000357700.11; ENSP00000350331.6; NM_024701.4; NP_078977.2.
DR UCSC; uc001iig.3; human. [Q8WXK3-1]
DR AGR; HGNC:19765; -.
DR CTD; 79754; -.
DR GeneCards; ASB13; -.
DR HGNC; HGNC:19765; ASB13.
DR HPA; ENSG00000196372; Low tissue specificity.
DR MIM; 615055; gene.
DR neXtProt; NX_Q8WXK3; -.
DR OpenTargets; ENSG00000196372; -.
DR PharmGKB; PA134992129; -.
DR VEuPathDB; HostDB:ENSG00000196372; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160326; -.
DR HOGENOM; CLU_000134_4_2_1; -.
DR InParanoid; Q8WXK3; -.
DR OMA; DARNIDC; -.
DR OrthoDB; 3036561at2759; -.
DR PhylomeDB; Q8WXK3; -.
DR TreeFam; TF331945; -.
DR PathwayCommons; Q8WXK3; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q8WXK3; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 79754; 13 hits in 1192 CRISPR screens.
DR ChiTaRS; ASB13; human.
DR GeneWiki; ASB13; -.
DR GenomeRNAi; 79754; -.
DR Pharos; Q8WXK3; Tdark.
DR PRO; PR:Q8WXK3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8WXK3; Protein.
DR Bgee; ENSG00000196372; Expressed in pigmented layer of retina and 184 other cell types or tissues.
DR Genevisible; Q8WXK3; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03729; SOCS_ASB13; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037334; ASB13_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24136:SF31; ANKYRIN REPEAT AND SOCS BOX CONTAINING 13; 1.
DR PANTHER; PTHR24136; SOWAH (DROSOPHILA) HOMOLOG; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50225; SOCS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..278
FT /note="Ankyrin repeat and SOCS box protein 13"
FT /id="PRO_0000066949"
FT REPEAT 18..47
FT /note="ANK 1"
FT REPEAT 51..80
FT /note="ANK 2"
FT REPEAT 84..113
FT /note="ANK 3"
FT REPEAT 116..145
FT /note="ANK 4"
FT REPEAT 149..178
FT /note="ANK 5"
FT REPEAT 181..210
FT /note="ANK 6"
FT DOMAIN 229..278
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT VAR_SEQ 173
FT /note="G -> A (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_000272"
FT VAR_SEQ 174..278
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_000273"
FT CONFLICT 104
FT /note="L -> S (in Ref. 2; BAB14456)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="S -> D (in Ref. 1; AAL57350)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 278 AA; 30007 MW; 6E54725A70AB32EF CRC64;
MEPRAADGCF LGDVGFWVER TPVHEAAQRG ESLQLQQLIE SGACVNQVTV DSITPLHAAS
LQGQARCVQL LLAAGAQVDA RNIDGSTPLC DACASGSIEC VKLLLSYGAK VNPPLYTASP
LHEACMSGSS ECVRLLIDVG ANLEAHDCHF GTPLHVACAR EHLDCVKVLL NAGANVNAAK
LHETALHHAA KVKNVDLIEM LIEFGGNIYA RDNRGKKPSD YTWSSSAPAK CFEYYEKTPL
TLSQLCRVNL RKATGVRGLE KIAKLNIPPR LIDYLSYN
//
