ID DCTR_ECO57 Reviewed; 176 AA.
AC Q8X5P3; Q7AA19;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 29-MAY-2013, entry version 70.
DE RecName: Full=HTH-type transcriptional regulator DctR;
GN Name=dctR; OrderedLocusNames=Z4909, ECs4378;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA Welch R.A., Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli
RT O157:H7 and genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
RN [3]
RP FUNCTION.
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=12704134; DOI=10.1128/IAI.71.5.2598-2606.2003;
RA Tatsuno I., Nagano K., Taguchi K., Rong L., Mori H., Sasakawa C.;
RT "Increased adherence to Caco-2 cells caused by disruption of the yhiE
RT and yhiF genes in enterohemorrhagic Escherichia coli O157:H7.";
RL Infect. Immun. 71:2598-2606(2003).
CC -!- FUNCTION: May act as a transcriptional regulator of dctA (By
CC similarity). Could be involved in the regulation of the genes
CC coding for the type III secretion system in enterohaemorragic
CC strains.
CC -!- INDUCTION: By acidic conditions. Could be induced by EvgA via the
CC induction of YdeO (By similarity).
CC -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
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DR EMBL; AE005174; AAG58639.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37801.1; -; Genomic_DNA.
DR PIR; B91176; B91176.
DR PIR; C86022; C86022.
DR RefSeq; NP_290078.1; NC_002655.2.
DR RefSeq; NP_312405.1; NC_002695.1.
DR ProteinModelPortal; Q8X5P3; -.
DR SMR; Q8X5P3; 119-176.
DR STRING; 155864.Z4909; -.
DR EnsemblBacteria; AAG58639; AAG58639; Z4909.
DR EnsemblBacteria; BAB37801; BAB37801; BAB37801.
DR GeneID; 915765; -.
DR GeneID; 961181; -.
DR KEGG; ece:Z4909; -.
DR KEGG; ecs:ECs4378; -.
DR PATRIC; 18358329; VBIEscCol44059_4331.
DR eggNOG; COG2771; -.
DR HOGENOM; HOG000125804; -.
DR OMA; HAFVIID; -.
DR ProtClustDB; CLSK880693; -.
DR BioCyc; ECOL386585:GJFA-4344-MONOMER; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00196; GerE; 1.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; Bipartite_resp_reg_C-effector; 1.
DR PROSITE; PS00622; HTH_LUXR_1; FALSE_NEG.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; DNA-binding; Transcription;
KW Transcription regulation.
FT CHAIN 1 176 HTH-type transcriptional regulator DctR.
FT /FTId=PRO_0000184147.
FT DOMAIN 109 174 HTH luxR-type.
FT DNA_BIND 133 152 H-T-H motif (By similarity).
SQ SEQUENCE 176 AA; 20451 MW; F1E35D5A3B82BB8C CRC64;
MFLIITRDTM FFTAMKNILS KGNVVHIQNE EEIDVMLHQN AFVIIDTLMN NVFHSNFLTQ
IERLKPVHVI IFSPFNIKRC LGKVPVTFVP RTITIIDFVA LINGSYCSVP EANVSLSRKQ
HQVLSCIANQ MTTEDILEKL KISLKTFYCH KHNIMMILNL KRINELVRHQ HIDYLV
//
