ID   Q8X6J2_ECO57            Unreviewed;       311 AA.
AC   Q8X6J2;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 2.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=Positive regulator for lys {ECO:0000313|EMBL:AAG57951.1};
GN   Name=lysR {ECO:0000313|EMBL:AAG57951.1};
GN   OrderedLocusNames=Z4157 {ECO:0000313|EMBL:AAG57951.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|EMBL:AAG57951.1, ECO:0000313|Proteomes:UP000002519};
RN   [1] {ECO:0000313|EMBL:AAG57951.1, ECO:0000313|Proteomes:UP000002519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC
RC   {ECO:0000313|Proteomes:UP000002519};
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G.III., Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000256|ARBA:ARBA00009437}.
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DR   EMBL; AE005174; AAG57951.1; -; Genomic_DNA.
DR   PIR; C85936; C85936.
DR   PIR; H91090; H91090.
DR   KEGG; ece:Z4157; -.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 3.40.190.290; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30427; TRANSCRIPTIONAL ACTIVATOR PROTEIN LYSR; 1.
DR   PANTHER; PTHR30427:SF1; TRANSCRIPTIONAL ACTIVATOR PROTEIN LYSR; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
FT   DOMAIN          4..61
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50931"
SQ   SEQUENCE   311 AA;  34475 MW;  9244231D5CB0D9A6 CRC64;
     MAAVNLRHIE IFHAVMTAGS LTEAAHLLHT SQPTVSRELA RFEKVIGLKL FERVRGRLHP
     TVQGLRLFEE VQRSWYGLDR IVSAAESLRE FRQGELSIAC LPVFSQSFLP QLLQPFLVRY
     PDVSLNIVPQ ESPLLEEWLS AQRHDLGLTE TLHTPAGTER XELLSLDELC VLPPGHPLAV
     KKVLTPDDFQ GENYISLSRT DSYRQLLDQL FTEHQVKRRM IVETHSAASV CAMVRAGVGV
     SVVNPLTALD YAASGLVVRR FSIAVPFTVS LIRPLHRPSS ALVQAFSEHL QAGLPKLVTS
     LDAILSSATT A
//