ID Q8XAV2_ECO57 Unreviewed; 442 AA.
AC Q8XAV2; A0A6M0JPW5; Q7AFN2;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=Pyrimidine permease {ECO:0000313|EMBL:BAB34675.2};
GN Name=rutG {ECO:0000313|EMBL:BAB34675.2};
GN ORFNames=ECs_1252 {ECO:0000313|EMBL:BAB34675.2};
OS Escherichia coli O157:H7.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334 {ECO:0000313|EMBL:BAB34675.2, ECO:0000313|Proteomes:UP000000558};
RN [1] {ECO:0000313|EMBL:BAB34675.2, ECO:0000313|Proteomes:UP000000558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC
RC {ECO:0000313|Proteomes:UP000000558};
RX PubMed=11258796; DOI=.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; BA000007; BAB34675.2; -; Genomic_DNA.
DR RefSeq; NP_309279.2; NC_002695.1.
DR RefSeq; WP_001301708.1; NZ_VOAI01000026.1.
DR AlphaFoldDB; Q8XAV2; -.
DR STRING; 155864.Z1505; -.
DR GeneID; 914118; -.
DR KEGG; ecs:ECs_1252; -.
DR PATRIC; fig|386585.9.peg.1355; -.
DR eggNOG; COG2233; Bacteria.
DR HOGENOM; CLU_017959_1_1_6; -.
DR OMA; FGLCPKF; -.
DR Proteomes; UP000000558; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR019918; Pyrimidine_permease_RutG_pred.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; TIGR03616; RutG; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000558};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 442 AA; 45567 MW; 32C63E3675A776CF CRC64;
MAMFGLPHWQ LKSTSTESGV VAPDERLPFA QTAVMGVQHA VAMFGATVLM PILMGLDPNL
SILMSGIGTL LFFFITGGRV PSYLGSSAAF VGVVIAATGF NGQGINPNIS IALGGIIACG
LVYTVIGLVV MKIGTRWIER LMPPVVTGAV VMAIGLNLAP IAVKSVSASG FDSWMAVMTV
LCIGLVAVFT RGMIQRLLIL VGLIVACLLY GVMTNVLGLG KAVDFTLVSH AAWFGLPHFS
TPAFNGQAMM LIAPVAVILV AENLGHLKAV AGMTGRNMDP YMGRAFVGDG LATMLSGSVG
SSGVTTYAEN IGVMAVTKVY STLVFVAAAV IAMLLGFSPK FGALIHTIPA AVIGGASIVV
FGLIAVAGAR IWVQNRVDLS QNGNLIMVAV TLVLGAGDFA LTLGGFTLGG IGTATFGAIL
LNALLSRRLV DVPPPEVVHQ EP
//
