ID RLUD_RALSO Reviewed; 358 AA.
AC Q8XYX8;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 01-MAY-2013, entry version 62.
DE RecName: Full=Ribosomal large subunit pseudouridine synthase D;
DE EC=5.4.99.23;
DE AltName: Full=23S rRNA pseudouridine(1911/1915/1917) synthase;
DE AltName: Full=rRNA pseudouridylate synthase D;
DE AltName: Full=rRNA-uridine isomerase D;
GN Name=rluD; OrderedLocusNames=RSc1628; ORFNames=RS03991;
OS Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=267608;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMI1000;
RX PubMed=11823852; DOI=10.1038/415497a;
RA Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S.,
RA Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L.,
RA Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N.,
RA Gaspin C., Lavie M., Moisan A., Robert C., Saurin W., Schiex T.,
RA Siguier P., Thebault P., Whalen M., Wincker P., Levy M.,
RA Weissenbach J., Boucher C.A.;
RT "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL Nature 415:497-502(2002).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil
CC at positions 1911, 1915 and 1917 in 23S ribosomal RNA (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: 23S rRNA
CC uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA
CC pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
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DR EMBL; AL646052; CAD15330.1; -; Genomic_DNA.
DR RefSeq; NP_519749.1; NC_003295.1.
DR ProteinModelPortal; Q8XYX8; -.
DR STRING; 267608.RSc1628; -.
DR EnsemblBacteria; CAD15330; CAD15330; RSc1628.
DR GeneID; 1220463; -.
DR KEGG; rso:RSc1628; -.
DR PATRIC; 20261929; VBIRalSol70888_1668.
DR eggNOG; COG0564; -.
DR HOGENOM; HOG000275919; -.
DR KO; K06180; -.
DR OMA; KTIPAQT; -.
DR ProtClustDB; CLSK2753610; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR InterPro; IPR002942; S4_RNA-bd.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; RNA-binding; rRNA processing.
FT CHAIN 1 358 Ribosomal large subunit pseudouridine
FT synthase D.
FT /FTId=PRO_0000162698.
FT DOMAIN 50 114 S4 RNA-binding.
FT ACT_SITE 171 171 By similarity.
SQ SEQUENCE 358 AA; 38688 MW; 0A11CDEA474BFB5A CRC64;
MSDDAVADLP AASQDADDTL DDEALDLSAP GAGQAIEPII VEIPEALHGE RLDKALAKLL
PDYSRSRLQQ WIDAGAVRVG GAAVRPRAAV CGGDRIEVVP QRADDENAFV AEPVDLDVVY
EDDTLLVINK PAGLVVHPAA GNWSGTVLNG LLHRYPQAAG LPRAGIVHRL DKETSGLMVV
ARTLPAQTDL VRQLQARTVK RTYLALVWGE TPEAGTIDAP IGRDPRDRTR MAIIETASGK
PARTHFKTLD VVDLGRAQVS LVQCQLETGR THQIRVHFES EGHPLLGDPV YTRNFRRGRP
QTIKAPLPAP FARQALHAVR LGLVHPASGQ SVHWHAGVPD DLAELMDALE MDPDVDLV
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