ID Q8Y744_LISMO Unreviewed; 342 AA.
AC Q8Y744;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Lmo1477 protein {ECO:0000313|EMBL:CAC99555.1};
GN OrderedLocusNames=lmo1477 {ECO:0000313|EMBL:CAC99555.1};
OS Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=169963 {ECO:0000313|EMBL:CAC99555.1, ECO:0000313|Proteomes:UP000000817};
RN [1] {ECO:0000313|EMBL:CAC99555.1, ECO:0000313|Proteomes:UP000000817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-679 / EGD-e {ECO:0000313|Proteomes:UP000000817};
RX PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.D.,
RA Fsihi H., Portillo F.G., Garrido P., Gautier L., Goebel W., Gomez-Lopez N.,
RA Hain T., Hauf J., Jackson D., Jones L.M., Kaerst U., Kreft J., Kuhn M.,
RA Kunst F., Kurapkat G., Madueno E., Maitournam A., Vicente J.M., Ng E.,
RA Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.C.,
RA Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A.,
RA Vazquez-Boland J.A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL591979; CAC99555.1; -; Genomic_DNA.
DR PIR; AE1259; AE1259.
DR RefSeq; NP_465002.1; NC_003210.1.
DR RefSeq; WP_010990135.1; NZ_CP023861.1.
DR AlphaFoldDB; Q8Y744; -.
DR STRING; 169963.gene:17594134; -.
DR PaxDb; 169963-lmo1477; -.
DR EnsemblBacteria; CAC99555; CAC99555; CAC99555.
DR GeneID; 986668; -.
DR KEGG; lmo:lmo1477; -.
DR PATRIC; fig|169963.11.peg.1517; -.
DR eggNOG; COG0451; Bacteria.
DR HOGENOM; CLU_007383_9_2_9; -.
DR OrthoDB; 9778052at2; -.
DR PhylomeDB; Q8Y744; -.
DR BioCyc; LMON169963:LMO1477-MONOMER; -.
DR Proteomes; UP000000817; Chromosome.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd05227; AR_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR PANTHER; PTHR10366:SF242; STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000817}.
FT DOMAIN 6..236
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 342 AA; 37862 MW; BDA3C241B8F53791 CRC64;
MKNNVLVTGG TGFLGMHIIF QLLQQGYQVK TTVRSLKSKE KVIEILQNNG ITDFTHLSFV
ELDLSKDEGW KEAMLDCEYV LSVASPVFFG KFKNEEELIS PAIEGITRIL QAAKEAKVKR
VVMTSNFGAI GFSNADKNSI TTEAYWTDEL AKGLSAYEKS KLIAEKEAWK FMENETELEF
ATINPVAIFG PSQSNHVSGS FDLLKNLLNG SMKRVINIPL NVVDARDVAD LHIRAMITPE
ANGERFIASA DGEISMADIA HLLQRERPEL VDKMPKKTLP NAAIRAAALF SKHAKEGELM
INMNRQISNS KARDVLGWKP ISTKEEAVLA AVDSLAKYGL LD
//
