ID Q8Y763_LISMO Unreviewed; 721 AA.
AC Q8Y763;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Lmo1438 protein {ECO:0000313|EMBL:CAC99516.1};
GN OrderedLocusNames=lmo1438 {ECO:0000313|EMBL:CAC99516.1};
OS Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=169963 {ECO:0000313|EMBL:CAC99516.1, ECO:0000313|Proteomes:UP000000817};
RN [1] {ECO:0000313|EMBL:CAC99516.1, ECO:0000313|Proteomes:UP000000817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-679 / EGD-e {ECO:0000313|Proteomes:UP000000817};
RX PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.D.,
RA Fsihi H., Portillo F.G., Garrido P., Gautier L., Goebel W., Gomez-Lopez N.,
RA Hain T., Hauf J., Jackson D., Jones L.M., Kaerst U., Kreft J., Kuhn M.,
RA Kunst F., Kurapkat G., Madueno E., Maitournam A., Vicente J.M., Ng E.,
RA Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.C.,
RA Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A.,
RA Vazquez-Boland J.A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; AL591979; CAC99516.1; -; Genomic_DNA.
DR PIR; AF1254; AF1254.
DR RefSeq; NP_464963.1; NC_003210.1.
DR RefSeq; WP_003721943.1; NZ_CP023861.1.
DR AlphaFoldDB; Q8Y763; -.
DR SMR; Q8Y763; -.
DR STRING; 169963.gene:17594095; -.
DR PaxDb; 169963-lmo1438; -.
DR EnsemblBacteria; CAC99516; CAC99516; CAC99516.
DR GeneID; 986843; -.
DR KEGG; lmo:lmo1438; -.
DR PATRIC; fig|169963.11.peg.1477; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_7_0_9; -.
DR OrthoDB; 9770103at2; -.
DR PhylomeDB; Q8Y763; -.
DR BioCyc; LMON169963:LMO1438-MONOMER; -.
DR Proteomes; UP000000817; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IBA:GO_Central.
DR GO; GO:0071972; F:peptidoglycan L,D-transpeptidase activity; IBA:GO_Central.
DR GO; GO:0071555; P:cell wall organization; IBA:GO_Central.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000817};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..302
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 349..682
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 689..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 79916 MW; 634800E0C9B46FC6 CRC64;
MKLNFRKKKK DSTKKKRAII PLRLNILFFI IFILFSVLIL RLGIVQIVQG DTYKRQLEET
DNVTVSKNVP RGSIYDRNYN LLVGNSAVKS ITYTRSQQTQ TAETLHVAQT LEKLITVEPE
KLTDRDLKDY WILTHQTESL NRLSAKEQAL DSSKAYKIQV DKVTKEDIAS LTSEDLKVAT
IYKKMTTGYA MTESVVKNKD VTDEEIARVS ENMDSLPGVD TTTDWNRYYT YDETLRSILG
SVSTAKEGLP KDKAEYYLSQ GYSRNDRVGK SYLEAQYESV LAGSKSQSES VLDSKGNIIE
TVNKYEGSKG KDLVLSVDVE FQKAVEEILQ KNIKQGKQYA GSDLFDRAFV VAMDPYSGEV
LALAGQKLND KGEFEDYSLG TFTTAYAMGS AVKGSTILGG IMDGAITNKT VFTDQPIVLK
GTKPKSSWFN RTGAGNRPLD PVGALEISSN SYMYQVAMKM GGANYVPNGP LRAPLSTFDD
MRYYYNQFGL GVKTGIDLPG EQTGYKGDDQ TIGKILDFAI GQYDSYTPLQ MAQYVSTIAN
GGSRIAPSMV KEIRNPSTNG DSVGTLATAN EPKVLNKIGV SESDIKTVQQ GFYEVTHGST
GTARTVFTSS DYDVAGKTGT ADAFYDGPKE GNKMASVWNT TFVGYAPVEK PEIAISVVVP
WIYRPYGTDQ KTNMKISKEV FDKYFELKKE RSESKKDTSK VEQPINNKEA AAKAQSEQTE
N
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