ID Q8YB80_BRUME Unreviewed; 565 AA.
AC Q8YB80; D0B659;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:AAL54262.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:AAL54262.1};
GN OrderedLocusNames=BMEII1020 {ECO:0000313|EMBL:AAL54262.1};
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914 {ECO:0000313|EMBL:AAL54262.1, ECO:0000313|Proteomes:UP000000419};
RN [1] {ECO:0000313|EMBL:AAL54262.1, ECO:0000313|Proteomes:UP000000419}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094
RC {ECO:0000313|Proteomes:UP000000419};
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.J.,
RA Haselkorn R., Kyrpides N., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
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DR EMBL; AE008918; AAL54262.1; -; Genomic_DNA.
DR PIR; AC3637; AC3637.
DR AlphaFoldDB; Q8YB80; -.
DR KEGG; bme:BMEII1020; -.
DR eggNOG; COG1250; Bacteria.
DR Proteomes; UP000000419; Chromosome II.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:AAL54262.1}.
FT DOMAIN 47..225
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 228..325
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 455..500
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 565 AA; 60713 MW; 860BD20EEB46EDC9 CRC64;
MAHWRLNERL SSFCSIRKTR KRAQPLSSKN ANLPITDART MERSINHIAI VGAGVMGTGI
AQIAAQAGLV TQIFDAREGA AAASLDRLAS TLAKLAEKGK ISAEDAQTAV SRIEICSSIQ
ELADCDLVVE AIVEKLDAKQ ALFLELEAVV SGNCILATNT SSLSVTSIAR VCRHPERVAG
FHFFNPVPLM KVVEVIDGLT TDPAVGDALL VLAKRMGHHG IRAKDMPGFI INHAGRAYGT
EALKILGECV APRGDIDRIL RESAGFRMGP LELFDLTGLD VSHPVMESIY NQFYQEPRYR
PSALTRQMLE GGYVGRKVGQ GFYRYEDGKM VAPPVPQPVP AVDIMPSVWI SADCDEDKEQ
LYALLRSLGA TVETGALPSA EALCLLAPYG YDATTACELA GSDPARTVCI DMLPGLDRHR
TLMMTPATSP AFRDAAHALL ARDGVNVTVI RDSVGFVAQR TLAAIVNLAC DIAQQGIATA
DDIDQAVRLG LGYPQGPLAW GGFSDPENIV AYAGINRRPP LQAKPMVAPQ GRAGPFPALR
GAGYRLEHFR AKSAKRLRGE ISPLD
//
