ID Q8YFE6_BRUME Unreviewed; 519 AA.
AC Q8YFE6;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 24-JAN-2024, entry version 124.
DE SubName: Full=Xanthine dehydrogenase {ECO:0000313|EMBL:AAL52757.1};
DE EC=1.17.1.4 {ECO:0000313|EMBL:AAL52757.1};
GN OrderedLocusNames=BMEI1576 {ECO:0000313|EMBL:AAL52757.1};
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914 {ECO:0000313|EMBL:AAL52757.1, ECO:0000313|Proteomes:UP000000419};
RN [1] {ECO:0000313|EMBL:AAL52757.1, ECO:0000313|Proteomes:UP000000419}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094
RC {ECO:0000313|Proteomes:UP000000419};
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.J.,
RA Haselkorn R., Kyrpides N., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
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DR EMBL; AE008917; AAL52757.1; -; Genomic_DNA.
DR PIR; AB3449; AB3449.
DR AlphaFoldDB; Q8YFE6; -.
DR KEGG; bme:BMEI1576; -.
DR eggNOG; COG4630; Bacteria.
DR OMA; AFHKIAK; -.
DR Proteomes; UP000000419; Chromosome I.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0004854; F:xanthine dehydrogenase activity; IEA:UniProtKB-EC.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 1.10.150.120; [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.30.390.50; CO dehydrogenase flavoprotein, C-terminal domain; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR002888; 2Fe-2S-bd.
DR InterPro; IPR036884; 2Fe-2S-bd_dom_sf.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR016208; Ald_Oxase/xanthine_DH.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR005107; CO_DH_flav_C.
DR InterPro; IPR036683; CO_DH_flav_C_dom_sf.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR002346; Mopterin_DH_FAD-bd.
DR InterPro; IPR012175; Xanth_DH_ssu_bac.
DR InterPro; IPR014307; Xanthine_DH_ssu.
DR NCBIfam; TIGR02963; xanthine_xdhA; 1.
DR PANTHER; PTHR11908:SF132; ALDEHYDE OXIDASE 1-RELATED; 1.
DR PANTHER; PTHR11908; XANTHINE DEHYDROGENASE; 1.
DR Pfam; PF03450; CO_deh_flav_C; 1.
DR Pfam; PF00941; FAD_binding_5; 1.
DR Pfam; PF01799; Fer2_2; 1.
DR PIRSF; PIRSF036557; XdhA_RC; 1.
DR SMART; SM01092; CO_deh_flav_C; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF55447; CO dehydrogenase flavoprotein C-terminal domain-like; 1.
DR SUPFAM; SSF47741; CO dehydrogenase ISP C-domain like; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022827};
KW Oxidoreductase {ECO:0000313|EMBL:AAL52757.1}.
FT DOMAIN 224..397
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 519 AA; 55897 MW; CEB40F031BAC83AD CRC64;
MRWKSALSFT APGFALFLFD MLGELSNMGQ SARHEIRFLL NGETIVLDRV SPTETLLDYL
RLSARLRGTK EGCGEGDCGA YTVLVGRVVD GGLVYESVNA CIRFVGSLDG CHVVTIEYLR
GADGDLHPVQ KAMVEFHGSQ CGFCTPGFVM SLYALWMRDP RPADAAIEKA LQDNLCRCTG
YEAIMRAARA ISDYGNVAQD PLAAERAHVL QRLTALRDGA RVEVGAGKDR LIVPADLDDF
ATILAAEPKA TIVAGSTDVG LWVTKMMRDI SPVVFIGHLE ELHSIREENG VVTIGAGVTY
TQAFGFLAGR IPALGQLINR IGGEQVRNMG TIGGNIANGS PIGDTPPPLI ALGATLTLRK
GAERRTIALE DFFIAYGKQD RGAGEFVEAV HVPLPGEGSR FAAYKVSKRR EEDITASLGA
FHLMLDAAGN VAHIRIAYGG MAATPKRAHA VETALMGKPW TEATVEAALE AYAQDYTPLT
DMRATAEYRL LVARNMLRRF YLETTGSGET LGALRGEAA
//