ID Q8Z6D0_SALTI Unreviewed; 262 AA.
AC Q8Z6D0; A0A0C8VMG4; A0A0C9GFK9; Q7CAB8;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 24-JAN-2024, entry version 131.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA {ECO:0000313|EMBL:CAD02091.1};
GN OrderedLocusNames=STY1857 {ECO:0000313|EMBL:CAD02091.1}, t1142
GN {ECO:0000313|EMBL:AAO68802.1};
GN ORFNames=CAJ76_21500 {ECO:0000313|EMBL:EDG8859362.1}, CAJ80_20590
GN {ECO:0000313|EMBL:EDG8903756.1}, CAJ85_21985
GN {ECO:0000313|EMBL:EDG8895017.1}, CAL67_22625
GN {ECO:0000313|EMBL:EDG8935373.1}, CB224_22135
GN {ECO:0000313|EMBL:EDH5803267.1}, CC884_21910
GN {ECO:0000313|EMBL:EDI0960351.1}, CC907_20865
GN {ECO:0000313|EMBL:EDI0995998.1}, CC972_22260
GN {ECO:0000313|EMBL:EDI1141295.1}, D4Z37_23010
GN {ECO:0000313|EMBL:EBS6528631.1}, D6Q30_20540
GN {ECO:0000313|EMBL:EBS1100609.1}, DKA88_23055
GN {ECO:0000313|EMBL:EBW2555297.1}, DNM71_22755
GN {ECO:0000313|EMBL:EBV0722975.1}, DNV09_22595
GN {ECO:0000313|EMBL:EBV1035370.1}, DS261_23360
GN {ECO:0000313|EMBL:EBX7036296.1}, DUQ91_23265
GN {ECO:0000313|EMBL:EBS0139665.1}, DUV11_22995
GN {ECO:0000313|EMBL:EBS5366803.1}, DVG36_22725
GN {ECO:0000313|EMBL:EBY2836370.1}, EBC38_23075
GN {ECO:0000313|EMBL:EBZ4084617.1}, EID90_22450
GN {ECO:0000313|EMBL:EBZ9857551.1}, ELQ62_23045
GN {ECO:0000313|EMBL:ECA4926708.1}, EU445_23200
GN {ECO:0000313|EMBL:ECB1387329.1}, EVI00_22405
GN {ECO:0000313|EMBL:ECB2195395.1}, F9R11_22715
GN {ECO:0000313|EMBL:EDB3138263.1}, F9Y21_22730
GN {ECO:0000313|EMBL:EDB3628891.1}, FI137_21290
GN {ECO:0000313|EMBL:EBG5396307.1}, G2227_22665
GN {ECO:0000313|EMBL:HAE0483549.1}, G2244_23095
GN {ECO:0000313|EMBL:HAE0419359.1}, G3982_004303
GN {ECO:0000313|EMBL:HAE3630547.1}, G3V49_003772
GN {ECO:0000313|EMBL:HAE1998679.1}, G4I71_004212
GN {ECO:0000313|EMBL:HAE6056841.1}, G4L28_004310
GN {ECO:0000313|EMBL:HAE6909549.1}, G4P30_004308
GN {ECO:0000313|EMBL:HAE7600770.1}, G4Y41_003733
GN {ECO:0000313|EMBL:HAE9016996.1}, G4Y55_004503
GN {ECO:0000313|EMBL:HAE9581577.1}, G9264_003938
GN {ECO:0000313|EMBL:HAF7400359.1}, G9C68_004542
GN {ECO:0000313|EMBL:HAF0688821.1}, G9X37_003363
GN {ECO:0000313|EMBL:HAF7362716.1}, GDI29_22315
GN {ECO:0000313|EMBL:EDH3997701.1}, GND71_004392
GN {ECO:0000313|EMBL:HAE7812410.1}, K3U68_05690
GN {ECO:0000313|EMBL:QZA30693.1}, ZZ17_21930
GN {ECO:0000313|EMBL:ECV8218262.1};
OS Salmonella typhi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370 {ECO:0000313|EMBL:CAD02091.1, ECO:0000313|Proteomes:UP000000541};
RN [1] {ECO:0000313|EMBL:CAD02091.1, ECO:0000313|Proteomes:UP000000541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18 {ECO:0000313|EMBL:CAD02091.1,
RC ECO:0000313|Proteomes:UP000000541};
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.,
RA Rutherford K., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2] {ECO:0000313|EMBL:AAO68802.1, ECO:0000313|Proteomes:UP000002670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2 {ECO:0000313|Proteomes:UP000002670}, and Ty2
RC {ECO:0000313|EMBL:AAO68802.1};
RX PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA Deng W., Liou S.R., Plunkett G.III., Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
RN [3] {ECO:0000313|EMBL:HAE0419359.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09-1703 {ECO:0000313|EMBL:HAE3630547.1}, 09-1978
RC {ECO:0000313|EMBL:HAE6056841.1}, 09-1979
RC {ECO:0000313|EMBL:HAE7600770.1}, 10-1436
RC {ECO:0000313|EMBL:HAE1998679.1}, 11-2088
RC {ECO:0000313|EMBL:HAE6909549.1}, 12-0098
RC {ECO:0000313|EMBL:HAF7400359.1}, 12-0437
RC {ECO:0000313|EMBL:HAF7362716.1}, 12-2005
RC {ECO:0000313|EMBL:HAE9016996.1}, 13-0747
RC {ECO:0000313|EMBL:HAF0688821.1}, 13-7562
RC {ECO:0000313|EMBL:HAE9581577.1}, IP E.88.374
RC {ECO:0000313|EMBL:HAE7812410.1},
RC Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC {ECO:0000313|EMBL:HAE0419359.1}, and
RC Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC {ECO:0000313|EMBL:HAE0483549.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [4] {ECO:0000313|EMBL:HAE1998679.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09-1703 {ECO:0000313|EMBL:HAE3630547.1}, 09-1978
RC {ECO:0000313|EMBL:HAE6056841.1}, 09-1979
RC {ECO:0000313|EMBL:HAE7600770.1}, 10-1436
RC {ECO:0000313|EMBL:HAE1998679.1}, 11-2088
RC {ECO:0000313|EMBL:HAE6909549.1}, 12-0098
RC {ECO:0000313|EMBL:HAF7400359.1}, 12-0437
RC {ECO:0000313|EMBL:HAF7362716.1}, 12-2005
RC {ECO:0000313|EMBL:HAE9016996.1}, 13-0747
RC {ECO:0000313|EMBL:HAF0688821.1}, 13-7562
RC {ECO:0000313|EMBL:HAE9581577.1}, IP E.88.374
RC {ECO:0000313|EMBL:HAE7812410.1},
RC Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC {ECO:0000313|EMBL:HAE0419359.1}, and
RC Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC {ECO:0000313|EMBL:HAE0483549.1};
RG NCBI Pathogen Detection Project;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:EDB3138263.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=116585 {ECO:0000313|EMBL:EDG8935373.1}, 132015
RC {ECO:0000313|EMBL:EDG8903756.1}, 14549
RC {ECO:0000313|EMBL:ECV8218262.1}, 186520
RC {ECO:0000313|EMBL:EDG8895017.1}, 189261
RC {ECO:0000313|EMBL:EDG8859362.1}, 257355
RC {ECO:0000313|EMBL:EBW2555297.1}, 338438
RC {ECO:0000313|EMBL:EDI1141295.1}, 339489
RC {ECO:0000313|EMBL:EDI0960351.1}, 348081
RC {ECO:0000313|EMBL:EDI0995998.1}, 365365
RC {ECO:0000313|EMBL:EDH5803267.1}, 524805
RC {ECO:0000313|EMBL:EBY2836370.1}, 531284
RC {ECO:0000313|EMBL:EBV1035370.1}, 539099
RC {ECO:0000313|EMBL:EBV0722975.1}, 550116
RC {ECO:0000313|EMBL:EBX7036296.1}, 550675
RC {ECO:0000313|EMBL:ECB1387329.1}, 550679
RC {ECO:0000313|EMBL:EBS5366803.1}, 568336
RC {ECO:0000313|EMBL:EBS0139665.1}, 588927
RC {ECO:0000313|EMBL:EBS6528631.1}, 606246
RC {ECO:0000313|EMBL:EBS1100609.1}, 619925
RC {ECO:0000313|EMBL:EBZ4084617.1}, 643219
RC {ECO:0000313|EMBL:EBZ9857551.1}, 656788
RC {ECO:0000313|EMBL:ECA4926708.1}, 673629
RC {ECO:0000313|EMBL:ECB2195395.1}, 731618
RC {ECO:0000313|EMBL:EBG5396307.1}, 814947
RC {ECO:0000313|EMBL:EDB3138263.1}, 815592
RC {ECO:0000313|EMBL:EDB3628891.1}, and 824494
RC {ECO:0000313|EMBL:EDH3997701.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QZA30693.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ISP2825 {ECO:0000313|EMBL:QZA30693.1};
RA Lee G.Y., Song J.;
RT "Complete Genome Sequence of Salmonella enterica Serovar Typhi Strain
RT ISP2825.";
RL Submitted (AUG-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; AE014613; AAO68802.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD02091.1; -; Genomic_DNA.
DR EMBL; AAFJDY010000048; EBG5396307.1; -; Genomic_DNA.
DR EMBL; AAGUIA010000040; EBS0139665.1; -; Genomic_DNA.
DR EMBL; AAGULE010000053; EBS1100609.1; -; Genomic_DNA.
DR EMBL; AAGVVD010000042; EBS5366803.1; -; Genomic_DNA.
DR EMBL; AAGWES010000039; EBS6528631.1; -; Genomic_DNA.
DR EMBL; AAHEBT010000040; EBV0722975.1; -; Genomic_DNA.
DR EMBL; AAHEEH010000052; EBV1035370.1; -; Genomic_DNA.
DR EMBL; AAHHUX010000039; EBW2555297.1; -; Genomic_DNA.
DR EMBL; AAHLZU010000040; EBX7036296.1; -; Genomic_DNA.
DR EMBL; AAHNRO010000045; EBY2836370.1; -; Genomic_DNA.
DR EMBL; AAHRAJ010000046; EBZ4084617.1; -; Genomic_DNA.
DR EMBL; AAHSWZ010000049; EBZ9857551.1; -; Genomic_DNA.
DR EMBL; AAHUNO010000045; ECA4926708.1; -; Genomic_DNA.
DR EMBL; AAHWPO010000041; ECB1387329.1; -; Genomic_DNA.
DR EMBL; AAHWWI010000039; ECB2195395.1; -; Genomic_DNA.
DR EMBL; AAKUKE010000047; ECV8218262.1; -; Genomic_DNA.
DR EMBL; AALNBT010000036; EDB3138263.1; -; Genomic_DNA.
DR EMBL; AALNGB010000038; EDB3628891.1; -; Genomic_DNA.
DR EMBL; AAMFQS010000044; EDG8859362.1; -; Genomic_DNA.
DR EMBL; AAMFQZ010000041; EDG8895017.1; -; Genomic_DNA.
DR EMBL; AAMFRD010000051; EDG8903756.1; -; Genomic_DNA.
DR EMBL; AAMFRJ010000119; EDG8935373.1; -; Genomic_DNA.
DR EMBL; AAMHNJ010000039; EDH3997701.1; -; Genomic_DNA.
DR EMBL; AAMICL010000040; EDH5803267.1; -; Genomic_DNA.
DR EMBL; AAMJUX010000046; EDI0960351.1; -; Genomic_DNA.
DR EMBL; AAMJVG010000049; EDI0995998.1; -; Genomic_DNA.
DR EMBL; AAMJWL010000038; EDI1141295.1; -; Genomic_DNA.
DR EMBL; DAAQQG010000038; HAE0419359.1; -; Genomic_DNA.
DR EMBL; DAAQQU010000036; HAE0483549.1; -; Genomic_DNA.
DR EMBL; DAARDQ010000065; HAE1998679.1; -; Genomic_DNA.
DR EMBL; DAARRK010000059; HAE3630547.1; -; Genomic_DNA.
DR EMBL; DAASLV010000053; HAE6056841.1; -; Genomic_DNA.
DR EMBL; DAASSY010000059; HAE6909549.1; -; Genomic_DNA.
DR EMBL; DAASYX010000043; HAE7600770.1; -; Genomic_DNA.
DR EMBL; DAATAS010000037; HAE7812410.1; -; Genomic_DNA.
DR EMBL; DAATOU010000078; HAE9016996.1; -; Genomic_DNA.
DR EMBL; DAATPQ010000035; HAE9581577.1; -; Genomic_DNA.
DR EMBL; DAATYW010000039; HAF0688821.1; -; Genomic_DNA.
DR EMBL; DAAWCE010000083; HAF7362716.1; -; Genomic_DNA.
DR EMBL; DAAWDS010000052; HAF7400359.1; -; Genomic_DNA.
DR EMBL; CP080960; QZA30693.1; -; Genomic_DNA.
DR RefSeq; NP_456247.1; NC_003198.1.
DR RefSeq; WP_000175788.1; NZ_WSUR01000044.1.
DR AlphaFoldDB; Q8Z6D0; -.
DR STRING; 220341.gene:17585783; -.
DR DNASU; 1248220; -.
DR KEGG; stt:t1142; -.
DR KEGG; sty:STY1857; -.
DR PATRIC; fig|220341.7.peg.1871; -.
DR eggNOG; COG1708; Bacteria.
DR HOGENOM; CLU_071584_0_0_6; -.
DR OMA; QQDWDIV; -.
DR OrthoDB; 7058480at2; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR041633; Polbeta.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF18765; Polbeta; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:EBG5396307.1}.
FT DOMAIN 27..73
FT /note="Polymerase beta nucleotidyltransferase"
FT /evidence="ECO:0000259|Pfam:PF18765"
FT DOMAIN 153..254
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 262 AA; 29536 MW; 71DD5A840A702751 CRC64;
MTLSIPPSIQ CQTEAACRLI TRVTGDTLRA IHLYGSAVAG DLKPNSDIDL LVTICQPLTE
TQRATLMQEL LALSSPPGAS AEKRALEVTV VLYSQLVPWC FPPSREMQFG EWLREDIYQG
IYEPAQQDWD MVLLITQILE TSIPLKGERA ERLFTPAPAA QLLKALRYPL DLWQSTADVQ
GDEYHIVLTL ARIWYTLSTG RFTSKDAAAD WLLPQLPEEY AATLRAAQRE YLGLEQQDWH
ILLPAVVRFV DFAKAYIPTQ FT
//