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Database: UniProt
Entry: Q8Z8B5_SALTI
LinkDB: Q8Z8B5_SALTI
Original site: Q8Z8B5_SALTI 
ID   Q8Z8B5_SALTI            Unreviewed;       350 AA.
AC   Q8Z8B5; A0A0B4NVW8; A0A0C9FHV1; Q7C8P6;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   24-JAN-2024, entry version 144.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   Name=aroG {ECO:0000313|EMBL:CAD05217.1};
GN   OrderedLocusNames=STY0801 {ECO:0000313|EMBL:CAD05217.1}, t2118
GN   {ECO:0000313|EMBL:AAO69735.1};
GN   ORFNames=CAJ76_16680 {ECO:0000313|EMBL:EDG8858458.1}, CAJ80_14390
GN   {ECO:0000313|EMBL:EDG8902591.1}, CAJ85_05110
GN   {ECO:0000313|EMBL:EDG8891859.1}, CAL67_06955
GN   {ECO:0000313|EMBL:EDG8932448.1}, CB224_06470
GN   {ECO:0000313|EMBL:EDH5800351.1}, CC884_20025
GN   {ECO:0000313|EMBL:EDI0959994.1}, CC907_04525
GN   {ECO:0000313|EMBL:EDI0992942.1}, CC972_18465
GN   {ECO:0000313|EMBL:EDI1140571.1}, D4Z37_11540
GN   {ECO:0000313|EMBL:EBS6526499.1}, D6Q30_11730
GN   {ECO:0000313|EMBL:EBS1098969.1}, DKA88_06400
GN   {ECO:0000313|EMBL:EBW2552221.1}, DNM71_10950
GN   {ECO:0000313|EMBL:EBV0720784.1}, DNV09_17835
GN   {ECO:0000313|EMBL:EBV1034471.1}, DS261_07070
GN   {ECO:0000313|EMBL:EBX7033282.1}, DUQ91_12150
GN   {ECO:0000313|EMBL:EBS0137604.1}, DUV11_10340
GN   {ECO:0000313|EMBL:EBS5364452.1}, DVG36_16870
GN   {ECO:0000313|EMBL:EBY2835277.1}, EBC38_17355
GN   {ECO:0000313|EMBL:EBZ4083538.1}, EID90_16110
GN   {ECO:0000313|EMBL:EBZ9856355.1}, ELQ62_16245
GN   {ECO:0000313|EMBL:ECA4925437.1}, EU445_06885
GN   {ECO:0000313|EMBL:ECB1384303.1}, EVI00_11895
GN   {ECO:0000313|EMBL:ECB2193437.1}, F9R11_07260
GN   {ECO:0000313|EMBL:EDB3135389.1}, F9Y21_06800
GN   {ECO:0000313|EMBL:EDB3625927.1}, FI137_12575
GN   {ECO:0000313|EMBL:EBG5394681.1}, G2227_14445
GN   {ECO:0000313|EMBL:HAE0482033.1}, G2244_07125
GN   {ECO:0000313|EMBL:HAE0416385.1}, G3982_002095
GN   {ECO:0000313|EMBL:HAE3628498.1}, G3V49_001280
GN   {ECO:0000313|EMBL:HAE1996371.1}, G4I71_002581
GN   {ECO:0000313|EMBL:HAE6055303.1}, G4L28_001802
GN   {ECO:0000313|EMBL:HAE6907201.1}, G4P30_002526
GN   {ECO:0000313|EMBL:HAE7599115.1}, G4Y41_000745
GN   {ECO:0000313|EMBL:HAE9014204.1}, G4Y55_001868
GN   {ECO:0000313|EMBL:HAE9579110.1}, G9264_002183
GN   {ECO:0000313|EMBL:HAF7398717.1}, G9C68_001500
GN   {ECO:0000313|EMBL:HAF0685983.1}, G9X37_001564
GN   {ECO:0000313|EMBL:HAF7361020.1}, GDI29_11895
GN   {ECO:0000313|EMBL:EDH3995739.1}, GND71_001390
GN   {ECO:0000313|EMBL:HAE7809606.1}, K3U68_10670
GN   {ECO:0000313|EMBL:QZA31572.1}, ZZ17_15905
GN   {ECO:0000313|EMBL:ECV8217123.1};
OS   Salmonella typhi.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370 {ECO:0000313|EMBL:CAD05217.1, ECO:0000313|Proteomes:UP000000541};
RN   [1] {ECO:0000313|EMBL:CAD05217.1, ECO:0000313|Proteomes:UP000000541}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18 {ECO:0000313|EMBL:CAD05217.1,
RC   ECO:0000313|Proteomes:UP000000541};
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.,
RA   Rutherford K., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2] {ECO:0000313|EMBL:AAO69735.1, ECO:0000313|Proteomes:UP000002670}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2 {ECO:0000313|Proteomes:UP000002670}, and Ty2
RC   {ECO:0000313|EMBL:AAO69735.1};
RX   PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA   Deng W., Liou S.R., Plunkett G.III., Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
RN   [3] {ECO:0000313|EMBL:HAE0416385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=09-1703 {ECO:0000313|EMBL:HAE3628498.1}, 09-1978
RC   {ECO:0000313|EMBL:HAE6055303.1}, 09-1979
RC   {ECO:0000313|EMBL:HAE7599115.1}, 10-1436
RC   {ECO:0000313|EMBL:HAE1996371.1}, 11-2088
RC   {ECO:0000313|EMBL:HAE6907201.1}, 12-0098
RC   {ECO:0000313|EMBL:HAF7398717.1}, 12-0437
RC   {ECO:0000313|EMBL:HAF7361020.1}, 12-2005
RC   {ECO:0000313|EMBL:HAE9014204.1}, 13-0747
RC   {ECO:0000313|EMBL:HAF0685983.1}, 13-7562
RC   {ECO:0000313|EMBL:HAE9579110.1}, IP E.88.374
RC   {ECO:0000313|EMBL:HAE7809606.1},
RC   Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC   {ECO:0000313|EMBL:HAE0416385.1}, and
RC   Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC   {ECO:0000313|EMBL:HAE0482033.1};
RX   PubMed=30286803;
RA   Souvorov A., Agarwala R., Lipman D.J.;
RT   "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL   Genome Biol. 19:153-153(2018).
RN   [4] {ECO:0000313|EMBL:HAE1996371.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=09-1703 {ECO:0000313|EMBL:HAE3628498.1}, 09-1978
RC   {ECO:0000313|EMBL:HAE6055303.1}, 09-1979
RC   {ECO:0000313|EMBL:HAE7599115.1}, 10-1436
RC   {ECO:0000313|EMBL:HAE1996371.1}, 11-2088
RC   {ECO:0000313|EMBL:HAE6907201.1}, 12-0098
RC   {ECO:0000313|EMBL:HAF7398717.1}, 12-0437
RC   {ECO:0000313|EMBL:HAF7361020.1}, 12-2005
RC   {ECO:0000313|EMBL:HAE9014204.1}, 13-0747
RC   {ECO:0000313|EMBL:HAF0685983.1}, 13-7562
RC   {ECO:0000313|EMBL:HAE9579110.1}, IP E.88.374
RC   {ECO:0000313|EMBL:HAE7809606.1},
RC   Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC   {ECO:0000313|EMBL:HAE0416385.1}, and
RC   Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC   {ECO:0000313|EMBL:HAE0482033.1};
RG   NCBI Pathogen Detection Project;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:EBS1098969.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=116585 {ECO:0000313|EMBL:EDG8932448.1}, 132015
RC   {ECO:0000313|EMBL:EDG8902591.1}, 14549
RC   {ECO:0000313|EMBL:ECV8217123.1}, 186520
RC   {ECO:0000313|EMBL:EDG8891859.1}, 189261
RC   {ECO:0000313|EMBL:EDG8858458.1}, 257355
RC   {ECO:0000313|EMBL:EBW2552221.1}, 338438
RC   {ECO:0000313|EMBL:EDI1140571.1}, 339489
RC   {ECO:0000313|EMBL:EDI0959994.1}, 348081
RC   {ECO:0000313|EMBL:EDI0992942.1}, 365365
RC   {ECO:0000313|EMBL:EDH5800351.1}, 524805
RC   {ECO:0000313|EMBL:EBY2835277.1}, 531284
RC   {ECO:0000313|EMBL:EBV1034471.1}, 539099
RC   {ECO:0000313|EMBL:EBV0720784.1}, 550116
RC   {ECO:0000313|EMBL:EBX7033282.1}, 550675
RC   {ECO:0000313|EMBL:ECB1384303.1}, 550679
RC   {ECO:0000313|EMBL:EBS5364452.1}, 568336
RC   {ECO:0000313|EMBL:EBS0137604.1}, 588927
RC   {ECO:0000313|EMBL:EBS6526499.1}, 606246
RC   {ECO:0000313|EMBL:EBS1098969.1}, 619925
RC   {ECO:0000313|EMBL:EBZ4083538.1}, 643219
RC   {ECO:0000313|EMBL:EBZ9856355.1}, 656788
RC   {ECO:0000313|EMBL:ECA4925437.1}, 673629
RC   {ECO:0000313|EMBL:ECB2193437.1}, 731618
RC   {ECO:0000313|EMBL:EBG5394681.1}, 814947
RC   {ECO:0000313|EMBL:EDB3135389.1}, 815592
RC   {ECO:0000313|EMBL:EDB3625927.1}, and 824494
RC   {ECO:0000313|EMBL:EDH3995739.1};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:QZA31572.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ISP2825 {ECO:0000313|EMBL:QZA31572.1};
RA   Lee G.Y., Song J.;
RT   "Complete Genome Sequence of Salmonella enterica Serovar Typhi Strain
RT   ISP2825.";
RL   Submitted (AUG-2021) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and
CC       D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-
CC       heptulosonate-7-phosphate (DAHP). {ECO:0000256|ARBA:ARBA00003726,
CC       ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC         Evidence={ECO:0000256|ARBA:ARBA00001370,
CC         ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7. {ECO:0000256|ARBA:ARBA00004688, ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|ARBA:ARBA00007985, ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; AE014613; AAO69735.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD05217.1; -; Genomic_DNA.
DR   EMBL; AAFJDY010000017; EBG5394681.1; -; Genomic_DNA.
DR   EMBL; AAGUIA010000012; EBS0137604.1; -; Genomic_DNA.
DR   EMBL; AAGULE010000019; EBS1098969.1; -; Genomic_DNA.
DR   EMBL; AAGVVD010000010; EBS5364452.1; -; Genomic_DNA.
DR   EMBL; AAGWES010000012; EBS6526499.1; -; Genomic_DNA.
DR   EMBL; AAHEBT010000011; EBV0720784.1; -; Genomic_DNA.
DR   EMBL; AAHEEH010000031; EBV1034471.1; -; Genomic_DNA.
DR   EMBL; AAHHUX010000006; EBW2552221.1; -; Genomic_DNA.
DR   EMBL; AAHLZU010000006; EBX7033282.1; -; Genomic_DNA.
DR   EMBL; AAHNRO010000022; EBY2835277.1; -; Genomic_DNA.
DR   EMBL; AAHRAJ010000022; EBZ4083538.1; -; Genomic_DNA.
DR   EMBL; AAHSWZ010000023; EBZ9856355.1; -; Genomic_DNA.
DR   EMBL; AAHUNO010000022; ECA4925437.1; -; Genomic_DNA.
DR   EMBL; AAHWPO010000006; ECB1384303.1; -; Genomic_DNA.
DR   EMBL; AAHWWI010000011; ECB2193437.1; -; Genomic_DNA.
DR   EMBL; AAKUKE010000023; ECV8217123.1; -; Genomic_DNA.
DR   EMBL; AALNBT010000005; EDB3135389.1; -; Genomic_DNA.
DR   EMBL; AALNGB010000005; EDB3625927.1; -; Genomic_DNA.
DR   EMBL; AAMFQS010000023; EDG8858458.1; -; Genomic_DNA.
DR   EMBL; AAMFQZ010000005; EDG8891859.1; -; Genomic_DNA.
DR   EMBL; AAMFRD010000024; EDG8902591.1; -; Genomic_DNA.
DR   EMBL; AAMFRJ010000013; EDG8932448.1; -; Genomic_DNA.
DR   EMBL; AAMHNJ010000011; EDH3995739.1; -; Genomic_DNA.
DR   EMBL; AAMICL010000006; EDH5800351.1; -; Genomic_DNA.
DR   EMBL; AAMJUX010000037; EDI0959994.1; -; Genomic_DNA.
DR   EMBL; AAMJVG010000005; EDI0992942.1; -; Genomic_DNA.
DR   EMBL; AAMJWL010000023; EDI1140571.1; -; Genomic_DNA.
DR   EMBL; DAAQQG010000006; HAE0416385.1; -; Genomic_DNA.
DR   EMBL; DAAQQU010000013; HAE0482033.1; -; Genomic_DNA.
DR   EMBL; DAARDQ010000012; HAE1996371.1; -; Genomic_DNA.
DR   EMBL; DAARRK010000017; HAE3628498.1; -; Genomic_DNA.
DR   EMBL; DAASLV010000024; HAE6055303.1; -; Genomic_DNA.
DR   EMBL; DAASSY010000014; HAE6907201.1; -; Genomic_DNA.
DR   EMBL; DAASYX010000016; HAE7599115.1; -; Genomic_DNA.
DR   EMBL; DAATAS010000006; HAE7809606.1; -; Genomic_DNA.
DR   EMBL; DAATOU010000007; HAE9014204.1; -; Genomic_DNA.
DR   EMBL; DAATPQ010000007; HAE9579110.1; -; Genomic_DNA.
DR   EMBL; DAATYW010000006; HAF0685983.1; -; Genomic_DNA.
DR   EMBL; DAAWCE010000027; HAF7361020.1; -; Genomic_DNA.
DR   EMBL; DAAWDS010000019; HAF7398717.1; -; Genomic_DNA.
DR   EMBL; CP080960; QZA31572.1; -; Genomic_DNA.
DR   RefSeq; NP_455311.1; NC_003198.1.
DR   RefSeq; WP_001109233.1; NZ_WSUR01000021.1.
DR   AlphaFoldDB; Q8Z8B5; -.
DR   STRING; 220341.gene:17584807; -.
DR   KEGG; stt:t2118; -.
DR   KEGG; sty:STY0801; -.
DR   PATRIC; fig|220341.7.peg.806; -.
DR   eggNOG; COG0722; Bacteria.
DR   HOGENOM; CLU_030903_0_1_6; -.
DR   OMA; DINTGLR; -.
DR   OrthoDB; 9807331at2; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DAHP_synth_1.
DR   NCBIfam; TIGR00034; aroFGH; 1.
DR   PANTHER; PTHR21225; PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE; 1.
DR   PANTHER; PTHR21225:SF12; PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHE-SENSITIVE; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW   ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001361}.
FT   DOMAIN          41..338
FT                   /note="DAHP synthetase I/KDSA"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
SQ   SEQUENCE   350 AA;  37868 MW;  C764207BBAB65FB7 CRC64;
     MNYQNDDLRI KEINELLPPV ALLEKFPATE NAANTVAHAR KAIHKILKGN DDRLLVVIGP
     CSIHDPAAAK EYAARLLALR DELQGELEIV MRVYFEKPRT TVGWKGLIND PHMDNSFQIN
     DGLRIARKLL LDINDSGLPA AGEFLDMITP QYLADLMSWG AIGARTTESQ VHRELASGLS
     CPVGFKNGTD GTIKVAIDAI NAAGAPHCFL SVTKWGHSAI VNTSGNGDCH IILRGGKAPN
     YSAQHVAEVK EGLIKAGLTP QVMIDFSHAN SCKQFQKQME VCADVCQQIA GGEKAIIGVM
     VESHLVEGNQ SLESGQPLTY GKSITDACIG WEDTDALLRQ LSAAVKARRG
//
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