ID Q8Z8E2_SALTI Unreviewed; 473 AA.
AC Q8Z8E2; A0A0C8TPB4; A0A3Y9LQP8; Q7C8M5;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE SubName: Full=Deoxyribodipyrimidine photo-lyase {ECO:0000313|EMBL:EBG5394963.1};
DE EC=4.1.99.3 {ECO:0000313|EMBL:EBG5394963.1};
DE SubName: Full=Deoxyribodipyrimidine photolyase {ECO:0000313|EMBL:CAD05171.1};
GN Name=phrB {ECO:0000313|EMBL:CAD05171.1};
GN OrderedLocusNames=STY0749 {ECO:0000313|EMBL:CAD05171.1}, t2167
GN {ECO:0000313|EMBL:AAO69778.1};
GN ORFNames=CAJ76_14785 {ECO:0000313|EMBL:EDG8858103.1}, CAJ80_21790
GN {ECO:0000313|EMBL:EDG8903979.1}, CAJ85_05350
GN {ECO:0000313|EMBL:EDG8891901.1}, CAL67_19035
GN {ECO:0000313|EMBL:EDG8934701.1}, CB224_06710
GN {ECO:0000313|EMBL:EDH5800393.1}, CC884_16255
GN {ECO:0000313|EMBL:EDI0959289.1}, CC907_04765
GN {ECO:0000313|EMBL:EDI0992984.1}, CC972_09080
GN {ECO:0000313|EMBL:EDI1138830.1}, D4Z37_11800
GN {ECO:0000313|EMBL:EBS6526544.1}, D6Q30_22330
GN {ECO:0000313|EMBL:EBS1100939.1}, DNM71_11215
GN {ECO:0000313|EMBL:EBV0720829.1}, DNV09_14540
GN {ECO:0000313|EMBL:EBV1033855.1}, DS261_07330
GN {ECO:0000313|EMBL:EBX7033327.1}, DUQ91_12410
GN {ECO:0000313|EMBL:EBS0137649.1}, DUV11_10600
GN {ECO:0000313|EMBL:EBS5364497.1}, DVG36_16080
GN {ECO:0000313|EMBL:EBY2835126.1}, EBC38_16520
GN {ECO:0000313|EMBL:EBZ4083381.1}, EID90_15255
GN {ECO:0000313|EMBL:EBZ9856201.1}, ELQ62_15490
GN {ECO:0000313|EMBL:ECA4925301.1}, EU445_07130
GN {ECO:0000313|EMBL:ECB1384346.1}, EVI00_12140
GN {ECO:0000313|EMBL:ECB2193480.1}, F9R11_07500
GN {ECO:0000313|EMBL:EDB3135431.1}, F9Y21_07040
GN {ECO:0000313|EMBL:EDB3625969.1}, FI137_14155
GN {ECO:0000313|EMBL:EBG5394963.1}, G2227_14690
GN {ECO:0000313|EMBL:HAE0482076.1}, G2244_07370
GN {ECO:0000313|EMBL:HAE0416428.1}, G3982_004541
GN {ECO:0000313|EMBL:HAE3630774.1}, G3V49_004094
GN {ECO:0000313|EMBL:HAE1998979.1}, G4I71_004532
GN {ECO:0000313|EMBL:HAE6057148.1}, G4L28_004732
GN {ECO:0000313|EMBL:HAE6909937.1}, G4P30_004488
GN {ECO:0000313|EMBL:HAE7600944.1}, G4Y41_003912
GN {ECO:0000313|EMBL:HAE9017161.1}, G4Y55_001916
GN {ECO:0000313|EMBL:HAE9579152.1}, G9264_004345
GN {ECO:0000313|EMBL:HAF7400742.1}, G9C68_001548
GN {ECO:0000313|EMBL:HAF0686025.1}, G9X37_003550
GN {ECO:0000313|EMBL:HAF7362896.1}, GDI29_12135
GN {ECO:0000313|EMBL:EDH3995781.1}, GND71_001438
GN {ECO:0000313|EMBL:HAE7809648.1}, K3U68_10915
GN {ECO:0000313|EMBL:QZA31610.1}, ZZ17_18300
GN {ECO:0000313|EMBL:ECV8217579.1};
OS Salmonella typhi.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370 {ECO:0000313|EMBL:CAD05171.1, ECO:0000313|Proteomes:UP000000541};
RN [1] {ECO:0000313|EMBL:CAD05171.1, ECO:0000313|Proteomes:UP000000541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18 {ECO:0000313|EMBL:CAD05171.1,
RC ECO:0000313|Proteomes:UP000000541};
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.,
RA Rutherford K., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2] {ECO:0000313|EMBL:AAO69778.1, ECO:0000313|Proteomes:UP000002670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2 {ECO:0000313|Proteomes:UP000002670}, and Ty2
RC {ECO:0000313|EMBL:AAO69778.1};
RX PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA Deng W., Liou S.R., Plunkett G.III., Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
RN [3] {ECO:0000313|EMBL:HAE0416428.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09-1703 {ECO:0000313|EMBL:HAE3630774.1}, 09-1978
RC {ECO:0000313|EMBL:HAE6057148.1}, 09-1979
RC {ECO:0000313|EMBL:HAE7600944.1}, 10-1436
RC {ECO:0000313|EMBL:HAE1998979.1}, 11-2088
RC {ECO:0000313|EMBL:HAE6909937.1}, 12-0098
RC {ECO:0000313|EMBL:HAF7400742.1}, 12-0437
RC {ECO:0000313|EMBL:HAF7362896.1}, 12-2005
RC {ECO:0000313|EMBL:HAE9017161.1}, 13-0747
RC {ECO:0000313|EMBL:HAF0686025.1}, 13-7562
RC {ECO:0000313|EMBL:HAE9579152.1}, IP E.88.374
RC {ECO:0000313|EMBL:HAE7809648.1},
RC Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC {ECO:0000313|EMBL:HAE0416428.1}, and
RC Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC {ECO:0000313|EMBL:HAE0482076.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [4] {ECO:0000313|EMBL:EBV0720829.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=116585 {ECO:0000313|EMBL:EDG8934701.1}, 132015
RC {ECO:0000313|EMBL:EDG8903979.1}, 14549
RC {ECO:0000313|EMBL:ECV8217579.1}, 186520
RC {ECO:0000313|EMBL:EDG8891901.1}, 189261
RC {ECO:0000313|EMBL:EDG8858103.1}, 338438
RC {ECO:0000313|EMBL:EDI1138830.1}, 339489
RC {ECO:0000313|EMBL:EDI0959289.1}, 348081
RC {ECO:0000313|EMBL:EDI0992984.1}, 365365
RC {ECO:0000313|EMBL:EDH5800393.1}, 524805
RC {ECO:0000313|EMBL:EBY2835126.1}, 531284
RC {ECO:0000313|EMBL:EBV1033855.1}, 539099
RC {ECO:0000313|EMBL:EBV0720829.1}, 550116
RC {ECO:0000313|EMBL:EBX7033327.1}, 550675
RC {ECO:0000313|EMBL:ECB1384346.1}, 550679
RC {ECO:0000313|EMBL:EBS5364497.1}, 568336
RC {ECO:0000313|EMBL:EBS0137649.1}, 588927
RC {ECO:0000313|EMBL:EBS6526544.1}, 606246
RC {ECO:0000313|EMBL:EBS1100939.1}, 619925
RC {ECO:0000313|EMBL:EBZ4083381.1}, 643219
RC {ECO:0000313|EMBL:EBZ9856201.1}, 656788
RC {ECO:0000313|EMBL:ECA4925301.1}, 673629
RC {ECO:0000313|EMBL:ECB2193480.1}, 731618
RC {ECO:0000313|EMBL:EBG5394963.1}, 814947
RC {ECO:0000313|EMBL:EDB3135431.1}, 815592
RC {ECO:0000313|EMBL:EDB3625969.1}, and 824494
RC {ECO:0000313|EMBL:EDH3995781.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:HAE1998979.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09-1703 {ECO:0000313|EMBL:HAE3630774.1}, 09-1978
RC {ECO:0000313|EMBL:HAE6057148.1}, 09-1979
RC {ECO:0000313|EMBL:HAE7600944.1}, 10-1436
RC {ECO:0000313|EMBL:HAE1998979.1}, 11-2088
RC {ECO:0000313|EMBL:HAE6909937.1}, 12-0098
RC {ECO:0000313|EMBL:HAF7400742.1}, 12-0437
RC {ECO:0000313|EMBL:HAF7362896.1}, 12-2005
RC {ECO:0000313|EMBL:HAE9017161.1}, 13-0747
RC {ECO:0000313|EMBL:HAF0686025.1}, 13-7562
RC {ECO:0000313|EMBL:HAE9579152.1}, IP E.88.374
RC {ECO:0000313|EMBL:HAE7809648.1},
RC Sam_1c96eabc-5ba9-4785-8bb4-b62bc64a6574
RC {ECO:0000313|EMBL:HAE0416428.1}, and
RC Sam_2e1fd039-ec06-4964-b74e-443d7665d7a0
RC {ECO:0000313|EMBL:HAE0482076.1};
RG NCBI Pathogen Detection Project;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QZA31610.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ISP2825 {ECO:0000313|EMBL:QZA31610.1};
RA Lee G.Y., Song J.;
RT "Complete Genome Sequence of Salmonella enterica Serovar Typhi Strain
RT ISP2825.";
RL Submitted (AUG-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000256|ARBA:ARBA00001932};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR602081-1};
CC Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR602081-1};
CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC {ECO:0000256|ARBA:ARBA00005862}.
CC -!- SIMILARITY: Belongs to the DNA photolyase family.
CC {ECO:0000256|RuleBase:RU004182}.
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DR EMBL; AE014613; AAO69778.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD05171.1; -; Genomic_DNA.
DR EMBL; AAFJDY010000021; EBG5394963.1; -; Genomic_DNA.
DR EMBL; AAGUIA010000012; EBS0137649.1; -; Genomic_DNA.
DR EMBL; AAGULE010000065; EBS1100939.1; -; Genomic_DNA.
DR EMBL; AAGVVD010000010; EBS5364497.1; -; Genomic_DNA.
DR EMBL; AAGWES010000012; EBS6526544.1; -; Genomic_DNA.
DR EMBL; AAHEBT010000011; EBV0720829.1; -; Genomic_DNA.
DR EMBL; AAHEEH010000021; EBV1033855.1; -; Genomic_DNA.
DR EMBL; AAHLZU010000006; EBX7033327.1; -; Genomic_DNA.
DR EMBL; AAHNRO010000020; EBY2835126.1; -; Genomic_DNA.
DR EMBL; AAHRAJ010000020; EBZ4083381.1; -; Genomic_DNA.
DR EMBL; AAHSWZ010000021; EBZ9856201.1; -; Genomic_DNA.
DR EMBL; AAHUNO010000021; ECA4925301.1; -; Genomic_DNA.
DR EMBL; AAHWPO010000006; ECB1384346.1; -; Genomic_DNA.
DR EMBL; AAHWWI010000011; ECB2193480.1; -; Genomic_DNA.
DR EMBL; AAKUKE010000031; ECV8217579.1; -; Genomic_DNA.
DR EMBL; AALNBT010000005; EDB3135431.1; -; Genomic_DNA.
DR EMBL; AALNGB010000005; EDB3625969.1; -; Genomic_DNA.
DR EMBL; AAMFQS010000018; EDG8858103.1; -; Genomic_DNA.
DR EMBL; AAMFQZ010000005; EDG8891901.1; -; Genomic_DNA.
DR EMBL; AAMFRD010000059; EDG8903979.1; -; Genomic_DNA.
DR EMBL; AAMFRJ010000068; EDG8934701.1; -; Genomic_DNA.
DR EMBL; AAMHNJ010000011; EDH3995781.1; -; Genomic_DNA.
DR EMBL; AAMICL010000006; EDH5800393.1; -; Genomic_DNA.
DR EMBL; AAMJUX010000024; EDI0959289.1; -; Genomic_DNA.
DR EMBL; AAMJVG010000005; EDI0992984.1; -; Genomic_DNA.
DR EMBL; AAMJWL010000007; EDI1138830.1; -; Genomic_DNA.
DR EMBL; DAAQQG010000006; HAE0416428.1; -; Genomic_DNA.
DR EMBL; DAAQQU010000013; HAE0482076.1; -; Genomic_DNA.
DR EMBL; DAARDQ010000078; HAE1998979.1; -; Genomic_DNA.
DR EMBL; DAARRK010000067; HAE3630774.1; -; Genomic_DNA.
DR EMBL; DAASLV010000066; HAE6057148.1; -; Genomic_DNA.
DR EMBL; DAASSY010000075; HAE6909937.1; -; Genomic_DNA.
DR EMBL; DAASYX010000049; HAE7600944.1; -; Genomic_DNA.
DR EMBL; DAATAS010000006; HAE7809648.1; -; Genomic_DNA.
DR EMBL; DAATOU010000087; HAE9017161.1; -; Genomic_DNA.
DR EMBL; DAATPQ010000007; HAE9579152.1; -; Genomic_DNA.
DR EMBL; DAATYW010000006; HAF0686025.1; -; Genomic_DNA.
DR EMBL; DAAWCE010000093; HAF7362896.1; -; Genomic_DNA.
DR EMBL; DAAWDS010000068; HAF7400742.1; -; Genomic_DNA.
DR EMBL; CP080960; QZA31610.1; -; Genomic_DNA.
DR RefSeq; NP_455268.1; NC_003198.1.
DR RefSeq; WP_001142014.1; NZ_WSUR01000015.1.
DR AlphaFoldDB; Q8Z8E2; -.
DR STRING; 220341.gene:17584758; -.
DR KEGG; stt:t2167; -.
DR KEGG; sty:STY0749; -.
DR PATRIC; fig|220341.7.peg.756; -.
DR eggNOG; COG0415; Bacteria.
DR HOGENOM; CLU_010348_2_2_6; -.
DR OMA; TPYKNAW; -.
DR OrthoDB; 9772484at2; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003904; F:deoxyribodipyrimidine photo-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0097159; F:organic cyclic compound binding; IEA:UniProt.
DR GO; GO:0051716; P:cellular response to stimulus; IEA:UniProt.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:UniProt.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR Gene3D; 1.25.40.80; -; 1.
DR Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR018394; DNA_photolyase_1_CS_C.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455; CRYPTOCHROME; 1.
DR PANTHER; PTHR11455:SF9; CRYPTOCHROME-1; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR Pfam; PF03441; FAD_binding_7; 1.
DR PRINTS; PR00147; DNAPHOTLYASE.
DR SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR PROSITE; PS00394; DNA_PHOTOLYASES_1_1; 1.
DR PROSITE; PS00691; DNA_PHOTOLYASES_1_2; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991, ECO:0000256|RuleBase:RU004182};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR602081-1};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|PIRSR:PIRSR602081-
KW 1}; Lyase {ECO:0000313|EMBL:EBG5394963.1}.
FT DOMAIN 2..134
FT /note="Photolyase/cryptochrome alpha/beta"
FT /evidence="ECO:0000259|PROSITE:PS51645"
FT BINDING 224
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 236..240
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 273
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 276..283
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT BINDING 374..376
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT SITE 308
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 361
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
FT SITE 384
FT /note="Electron transfer via tryptophanyl radical"
FT /evidence="ECO:0000256|PIRSR:PIRSR602081-2"
SQ SEQUENCE 473 AA; 53785 MW; 846C9193C0908C8C CRC64;
MPTHLVWFRR DLRLQDNLAL AAACRDASAR VLALYISTPA QWQAHDMAPR QAAFISAQLN
ALQTALAEKG IPLLFHEVAD FNASIETVKN VCRQHDVSHL FYNYQYEFNE RQRDAAVEKT
LPSVICEGFD DSVILAPGAV MTGNHEMYKV FTPFKNAWLK RLKEDIPPCV PAPKIRVSGA
LSIPLTPVSL NYPQQAFDAA LFPVEENAVI AQLRHFCSQG ADEYASRRDF PAVDGTSRLS
ASLATGGLSP RQCLHRLLAE QPQALDGGPG SVWLNELIWR EFYRHLMTWY PALCKHQPFI
RWTKRVAWQE NPHYFQAWQK GETGYPIVDA AMRQLNATGW MHNRLRMITA SFLVKDLLID
WRLGERYFMS QLIDGDLAAN NGGWQWAAST GTDAAPYFRI FNPTTQRERF DRDGEFIRQW
LPALRDIPGK AIHEPWRWAE KAGVVLDYPR PIVEHKQARI ATLSAYEAAR KGA
//
