ID RLUD_YERPE Reviewed; 325 AA.
AC Q8ZBV7; Q0WC11;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 01-MAY-2013, entry version 79.
DE RecName: Full=Ribosomal large subunit pseudouridine synthase D;
DE EC=5.4.99.23;
DE AltName: Full=23S rRNA pseudouridine(1911/1915/1917) synthase;
DE AltName: Full=rRNA pseudouridylate synthase D;
DE AltName: Full=rRNA-uridine isomerase D;
GN Name=rluD; Synonyms=sfhB; OrderedLocusNames=YPO3277, y0912, YP_0654;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/JB.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA Yang H., Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil
CC at positions 1911, 1915 and 1917 in 23S ribosomal RNA (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: 23S rRNA
CC uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA
CC pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC -!- SIMILARITY: Contains 1 S4 RNA-binding domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL590842; CAL21870.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84494.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS60921.1; -; Genomic_DNA.
DR PIR; AC0398; AC0398.
DR RefSeq; NP_668243.1; NC_004088.1.
DR RefSeq; NP_992044.1; NC_005810.1.
DR RefSeq; YP_002348177.1; NC_003143.1.
DR ProteinModelPortal; Q8ZBV7; -.
DR SMR; Q8ZBV7; 2-325.
DR STRING; 214092.YPO3277; -.
DR DNASU; 1145859; -.
DR EnsemblBacteria; AAM84494; AAM84494; y0912.
DR EnsemblBacteria; AAS60921; AAS60921; YP_0654.
DR GeneID; 1145859; -.
DR GeneID; 1176095; -.
DR GeneID; 2766710; -.
DR KEGG; ype:YPO3277; -.
DR KEGG; ypk:y0912; -.
DR KEGG; ypm:YP_0654; -.
DR eggNOG; COG0564; -.
DR HOGENOM; HOG000275919; -.
DR KO; K06180; -.
DR OMA; KTIPAQT; -.
DR ProtClustDB; PRK11180; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR InterPro; IPR002942; S4_RNA-bd.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Reference proteome; RNA-binding;
KW rRNA processing.
FT CHAIN 1 325 Ribosomal large subunit pseudouridine
FT synthase D.
FT /FTId=PRO_0000162709.
FT DOMAIN 18 91 S4 RNA-binding.
FT ACT_SITE 139 139 By similarity.
FT CONFLICT 291 291 R -> S (in Ref. 3; AAS60921).
SQ SEQUENCE 325 AA; 36706 MW; F05D5B6CDD123ADF CRC64;
MAQQVQLSAT VAESQLGQRL DQALAELFPD YSRSRIKEWI LDSRVTVNGK KINKPKEKVL
GGELVAIDAQ IEEDARWAPQ EIPLDIVYED NDILVINKPR GLVVHPGAGN PDGTVLNALL
HYYPEIMDVP RAGIVHRLDK DTTGLMVVAK TVPAQTRLVE ALQAREITRE YEAVAIGNMT
AGGRVDEPIS RHSTKRTHMA VHPMGKPATT HYRIMEHFRA HTRLRLRLET GRTHQIRVHM
SHINHPLVGD QLYGGRPRPP KGASDSFIAI LRGFDRQALH ATMLRLYHPI RGIQMEWHAA
LPEDMVELIN ALKADTEEFK DQMDW
//
