ID Q8ZP95_SALTY Unreviewed; 1300 AA.
AC Q8ZP95;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE SubName: Full=ATP-dependent helicase {ECO:0000313|EMBL:AAL20559.1};
GN Name=hrpA {ECO:0000313|EMBL:AAL20559.1};
GN OrderedLocusNames=STM1641 {ECO:0000313|EMBL:AAL20559.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL20559.1, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL20559.1, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
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DR EMBL; AE006468; AAL20559.1; -; Genomic_DNA.
DR RefSeq; NP_460600.3; NC_003197.2.
DR RefSeq; WP_000139701.1; NC_003197.2.
DR AlphaFoldDB; Q8ZP95; -.
DR STRING; 99287.STM1641; -.
DR PaxDb; 99287-STM1641; -.
DR GeneID; 1253159; -.
DR KEGG; stm:STM1641; -.
DR PATRIC; fig|99287.12.peg.1733; -.
DR HOGENOM; CLU_001832_3_3_6; -.
DR PhylomeDB; Q8ZP95; -.
DR BioCyc; SENT99287:STM1641-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd17989; DEXHc_HrpA; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR024590; HrpA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11898; DUF3418; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:AAL20559.1};
KW Hydrolase {ECO:0000313|EMBL:AAL20559.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001014}.
FT DOMAIN 87..250
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 274..444
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1300 AA; 148712 MW; 1A7A4A2D3B46234B CRC64;
MTEQSTLTLQ VLQQRLDALM LRDKQRFARR LHGVKKVKNP DAQQAIFQTM AKEIEQAAAQ
VALREAARPS ITYPQNLPVS QKKQDILEAI RDHQVVIVAG ETGSGKTTQL PKICMELGRG
IKGLIGHTQP RRLAARTVAN RIAEELQTEP GGCIGYKVRF SDHVSSNTMV KLMTDGILLA
EIQQDRLLMQ YDTLIIDEAH ERSLNIDFLL GYLKELLPRR PDLKVIITSA TIDPERFSRH
FNNAPIIEVS GRTYPVEVRY RPIVEEADDT ERDQLQAIFD AVDELGRESP GDILIFMSGE
REIRDTADAL NKLNLRHTEV LPLYARLSNS EQNRVFQSHS GRRIVLATNV AETSLTVPGI
KYVIDPGTAR ISRYSYRTKV QRLPIEPISQ ASANQRKGRC GRVSEGICIR LYSEDDFLSR
PEFTDPEILR TNLASVILQM TALGLGDIAA FPFVEAPDKR NIQDGVRLLE ELGAITADEQ
QTAYKLTPLG RQLSQLPVDP RLARMVLEAQ KHGCVREAMI ITSALSIQDP RERPVDKQQA
SDEKHRRFHD KESDFLAFVN LWNYLGEQQK ALSSNQFRRL CRTDYLNYLR VREWQDIYTQ
LRQVVKELGI PVNSEPAEYR EIHVALLTGL LSHIGMKDAD KQEYTGARNA RFSIFPGSGL
FKKPPKWTMV AELVETSRLW GRIAARIEPE WVEPVAQHLI KRSYSEPHWE RAQGAVMATE
KVTVYGLPIV AARKVNYSQI DPALCRELFI RHALVEGDWQ TRHAFFRENL KLRAEVEELE
HKSRRRDILV DDDTLFEFYD QRISHDVISA RHFDSWWKKI SRETPDLLNF EKSMLIKEGA
EKISKLDYPN FWHQGNLKLR LSYQFEPGAD ADGVTVHIPL PLLNQVDESG FEWQIPGLRR
ELVIALIKSL PKPVRRNFVP APNYAEAFLG RVTPLELPLL DALERELRRM TGVTVDREDW
HWDQVPEHLK ITFRVVNDKN KKLQEGRSLA ELKNALKGKV QETLSAVADD GIEQSGLHIW
SFGELPESYE QKRGNYKVKA WPALVDERDS VAIKLFDNPL EQQQAMWCGL RRLLLLNIPS
PIKYLHEKLP NKAKLGLYFN PYGKVLELID DCIACGVDKL IDANGGPVWS EAGFTALHEK
VRAELNDTVV DIAKQVERIL TTVFNINKRL KGRVDMSMAL GLSDIKAQMS GLVYRGFVTG
NGFKRLGDTL RYLQAIEKRL EKLAVDPHRD RAQMLKVESV QQAWQQWINK LPPARREDDD
VKEIRWMIEE LRVSYFAQQL GTPYPISDKR ILQAMDQITA
//
