ID Q8ZPW0_SALTY Unreviewed; 285 AA.
AC Q8ZPW0;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Aldehyde reductase {ECO:0000313|EMBL:AAL20213.1};
GN OrderedLocusNames=STM1288 {ECO:0000313|EMBL:AAL20213.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL20213.1, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL20213.1, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
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DR EMBL; AE006468; AAL20213.1; -; Genomic_DNA.
DR RefSeq; NP_460254.1; NC_003197.2.
DR RefSeq; WP_000843751.1; NC_003197.2.
DR AlphaFoldDB; Q8ZPW0; -.
DR STRING; 99287.STM1288; -.
DR PaxDb; 99287-STM1288; -.
DR GeneID; 1252806; -.
DR KEGG; stm:STM1288; -.
DR PATRIC; fig|99287.12.peg.1369; -.
DR HOGENOM; CLU_023205_2_3_6; -.
DR OMA; ACATNQV; -.
DR PhylomeDB; Q8ZPW0; -.
DR BioCyc; SENT99287:STM1288-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd19138; AKR_YeaE; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001014}.
FT DOMAIN 18..273
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 56
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 114
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 81
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 285 AA; 31328 MW; B6E86E8D8D2025C5 CRC64;
MKSVKNVTFC GQVTLPAIGQ GTWYMGERAD QRQREVSALR AGLDLGLRLI DTAEMYADGG
AEKVVGEALA GRRDEAFLVS KVYPWNAGGQ KIVAACEESL RRLKTDYLDL YLLHWAGSFS
FEETVEGMER LIAQGKIRRW GVSNLDYDDM QALWRIPGGQ QCATNQVLYH LASRGIEYDL
LPWCQQQRMP VMAYSPLAQA GRLRSGLLNH PVVNEIAQAH NATAAQILLT WVIAHPGVMA
IPKAGSTEHV KQNAAALEIA LSANELALLD NAWPAPKGKT ALDMV
//
