ID Q8ZV70_PYRAE Unreviewed; 411 AA.
AC Q8ZV70;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AAL64186.1};
GN OrderedLocusNames=PAE2426 {ECO:0000313|EMBL:AAL64186.1};
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306 {ECO:0000313|EMBL:AAL64186.1, ECO:0000313|Proteomes:UP000002439};
RN [1] {ECO:0000313|EMBL:AAL64186.1, ECO:0000313|Proteomes:UP000002439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 /
RC IM2 {ECO:0000313|Proteomes:UP000002439};
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AE009441; AAL64186.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZV70; -.
DR STRING; 178306.PAE2426; -.
DR EnsemblBacteria; AAL64186; AAL64186; PAE2426.
DR KEGG; pai:PAE2426; -.
DR PATRIC; fig|178306.9.peg.1810; -.
DR eggNOG; arCOG01356; Archaea.
DR HOGENOM; CLU_042889_0_0_2; -.
DR InParanoid; Q8ZV70; -.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR023980; CHP04013_B12-bd/rSAM.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR NCBIfam; TIGR04013; B12_SAM_MJ_1487; 1.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002439}.
FT DOMAIN 1..120
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 149..382
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 411 AA; 45697 MW; E93F2A0E94DAEAD6 CRC64;
MILLARVFEG PNNGLAYAVA PVEDKYKIIP TKDPLLDAAN LYAKGEKVLI LYSLSTPLFV
EIWRELIAVA GRFPVVAGGP HAAGDPITLL KLGVKYVVVG DGEVALPAII EKEEGLSDET
PPNVLIMEDG KVKAGRRVYT ELVYKTYSEA LGAYPPIEIM RSCGYRCAFC QTWAQGPVRY
RPLEKVEEMV KVYVKKGRRE IRFIAPVGFL YQSKDGKTPN IDALISLLKT VREAGGLPFL
GTFPSETRPE TVTRDVLSAL KNLLANKRLS FGLQTASERL LKLAKRGHDV ATVEEAVVTA
RAFGFTPVVD IIAGLPGEDE EDVVATVKTM ERLAAMGARI RMHYFIPLPG TPLWGREPSP
PHKLYTEFAK RYRKKVEGYW EEQIQLSRRI IETYRQISGY LSRTTPISKA S
//
