ID ECR1_PYRAE Reviewed; 235 AA.
AC Q8ZVM8;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 01-MAY-2013, entry version 66.
DE RecName: Full=Probable exosome complex RNA-binding protein 1;
GN OrderedLocusNames=PAE2208;
OS Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630
OS / NBRC 100827).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales;
OC Thermoproteaceae; Pyrobaculum.
OX NCBI_TaxID=178306;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827;
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- FUNCTION: Probably involved in degradation of a variety of RNA
CC species; could act a RNA-binding component of the exosome
CC (Potential).
CC -!- SUBUNIT: Component of the archaeal exosome multienzyme
CC ribonuclease complex (Potential).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- SIMILARITY: Contains 1 KH domain.
CC -!- SIMILARITY: Contains 1 S1 motif domain.
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DR EMBL; AE009441; AAL64028.1; -; Genomic_DNA.
DR RefSeq; NP_559846.1; NC_003364.1.
DR ProteinModelPortal; Q8ZVM8; -.
DR STRING; 178306.PAE2208; -.
DR EnsemblBacteria; AAL64028; AAL64028; PAE2208.
DR GeneID; 1464362; -.
DR KEGG; pai:PAE2208; -.
DR eggNOG; COG1097; -.
DR HOGENOM; HOG000229527; -.
DR KO; K03679; -.
DR OMA; VIPLEGP; -.
DR ProtClustDB; PRK04163; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:HAMAP.
DR GO; GO:0006401; P:RNA catabolic process; IEA:HAMAP.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00623; Exosome_RNA-bind1; 1; -.
DR InterPro; IPR023474; Exosome_RNA_bind1.
DR InterPro; IPR026699; Exosome_RNA_bind1/RRP40/RRP4.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; Rbsml_prot_S1_RNA-bd_dom.
DR InterPro; IPR022967; RNA-binding_domain_S1.
DR PANTHER; PTHR21321; PTHR21321; 1.
DR Pfam; PF00013; KH_1; 1.
DR SMART; SM00322; KH; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR PROSITE; PS50084; KH_TYPE_1; FALSE_NEG.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Exosome; Reference proteome;
KW RNA-binding.
FT CHAIN 1 235 Probable exosome complex RNA-binding
FT protein 1.
FT /FTId=PRO_0000050151.
FT DOMAIN 63 137 S1 motif.
FT DOMAIN 147 203 KH.
SQ SEQUENCE 235 AA; 26075 MW; CF751F97D8F05A52 CRC64;
MYYVTPRQLV FPGDVIATAD SKVEGPVYLD NGKYRSLVVG LVEFREDVVV VVPLEGTYKP
KKGDLVIGYV TDVLATGWEV DVRSFMPAYL PVGEALHRHV DLETTPLTTF LNIGDVVVAK
VKDVDLTDEY PIILTLKDEK VGKVESGTVV EITPVKVPRV IGKRGSMLNT LMELGCDIVV
GQNGRIWVKC KDPRDEVFLA SLIRKIEAES HVMGLTDRIR AEIENYKTSK QQGTV
//
