ID Q8ZY88_PYRAE Unreviewed; 680 AA.
AC Q8ZY88;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=PAE0901 {ECO:0000313|EMBL:AAL63108.1};
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306 {ECO:0000313|EMBL:AAL63108.1, ECO:0000313|Proteomes:UP000002439};
RN [1] {ECO:0000313|EMBL:AAL63108.1, ECO:0000313|Proteomes:UP000002439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 /
RC IM2 {ECO:0000313|Proteomes:UP000002439};
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR EMBL; AE009441; AAL63108.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZY88; -.
DR STRING; 178306.PAE0901; -.
DR EnsemblBacteria; AAL63108; AAL63108; PAE0901.
DR KEGG; pai:PAE0901; -.
DR PATRIC; fig|178306.9.peg.662; -.
DR eggNOG; arCOG00439; Archaea.
DR HOGENOM; CLU_000995_6_0_2; -.
DR InParanoid; Q8ZY88; -.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0042555; C:MCM complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR CDD; cd17761; MCM_arch; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013429; Regulatory_FmdB_Zinc_ribbon.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; NF040949; minchrom_main_MCM; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF43; DNA REPLICATION LICENSING FACTOR MCM6; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00834; CxxC_CXXC_SSSS; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000002439}.
FT DOMAIN 279..485
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 680 AA; 76173 MW; 79409981D729D151 CRC64;
MSLEIELDLL RDKFRELVTS NEKISDEVIN IIIQRKRSLE VDFHDILMFD KSLADLVVER
PKLVLPEADK VVREIVEEKD PETAKALKRF YFRVRGSPLS VSLRKLRSEY IGRLIKIEGI
VTRQTPPKHF LYKALYRCTQ CGYEIELLQE LERHVEPPAK CPRCGASKSF TLVTELSQYI
DWQKVIVQER PEDLPPGQLP RSVEVVLLDD LVDTVKPGDI ISLTGVVDLT LSELKKGRPP
IVTSYIQGVH VDTMNKELVE EITKEDEQKI LEISRRPDVR ELIIRSIAPS IYGYEEVKEA
VACLLFGGNE IVYPDGVRVR GDINILLIGD PGTAKSQLLK FVAKIAPRAV YTTGKGSSAA
GLTAAVVRDK LTGEFYLEAG ALVLADKGVA VIDEIDKMDA KDRVALHEAM EQNTVSISKA
GIVATLNARA AVLAAANPAF GRYLPNRTVA ENIDLPVSLL SRFDLIFVIR DEPREEFDSA
VAGHILDLHS GKTPEAFRDV LRPDFLRKYI MYARRYVRPI LSEEAKERIK AFYLEMRKRY
QGPGTAIAIT ARQLEALIRL TTAEAKMRLS PIAAAEDAER AIRLYLAFLK SVGIDIESGA
IDIDAIITGV PASRREAYIK VVELLKKLEE AERGPVKIDR LKAEAEKLGI PPAEVQRIVE
LLIRNGEAYT PRPGYIKRVG
//
