ID HXB1_CYPCA Reviewed; 315 AA.
AC Q90346; Q90345;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Homeobox protein Hox-B1;
GN Name=hoxb1;
OS Cyprinus carpio (Common carp).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Cyprinus.
OX NCBI_TaxID=7962;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8793616;
RA Stevens C.J.M., Samallo J., Schipper H., Stroband H.W.J., Te Kronnie G.;
RT "Expression of Hoxb-1 during gastrulation and segmentation stages of carp
RT (Cyprinus carpio).";
RL Int. J. Dev. Biol. 40:463-470(1996).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Acts on the
CC anterior body structures (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA62553.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X91079; CAA62554.1; -; mRNA.
DR EMBL; X91079; CAA62553.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q90346; -.
DR SMR; Q90346; -.
DR Proteomes; UP000694384; Unplaced.
DR Proteomes; UP000694427; Unplaced.
DR Proteomes; UP000694700; Unplaced.
DR Proteomes; UP000694701; Unplaced.
DR Proteomes; UP001155660; Genome assembly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946:SF5; HOMEOBOX PROTEIN HOX-B1; 1.
DR PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..315
FT /note="Homeobox protein Hox-B1"
FT /id="PRO_0000200112"
FT DNA_BIND 221..280
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 177..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 197..202
FT /note="Antp-type hexapeptide"
SQ SEQUENCE 315 AA; 34781 MW; 96274EC6D4213322 CRC64;
MDNSSMNSFL EYTICNRGTN AYSPKAGYQH LDQALSGPFH TGHARYSHNA DGRLYIGGSN
QPAAAQHQHQ SGVYAHHQHQ THQSGIGLTY GGTGTTSYGT QACANPDYAQ HQYFINPEQD
GMYYHSSGFS NSNLGPHYGS MAGAYCGAQG AVPAAPYQHH GCEGQDHQRG YSQGTYADLS
RSQGRERDTD QSPPGKTFDW MKVKRNPPKT AKVADYGLGP QNTIRTNFTT KQLTELEKEF
HFSKYLTRAR RVEIAATLEL NETQVKIWFQ NRRMKQKKRE KEGLAPASST LSKDLEDHSD
HSTSTSPGAS PSPDS
//
