ID Q904Y7_9HIV1 Unreviewed; 201 AA.
AC Q904Y7;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAL29318.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAL29318.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAL29318.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAL29318.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11865396; DOI=10.1086/338831;
RA Naugler W.E., Yong F.H., Carey V.J., Dragavon J.A., Coombs R.W.,
RA Frenkel L.M.;
RT "T69D/N pol mutation, human immunodeficiency virus type 1 RNA levels, and
RT syncytium-inducing phenotype are associated with CD4 cell depletion during
RT didanosine therapy.";
RL J. Infect. Dis. 185:448-455(2002).
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DR EMBL; AF422710; AAL29318.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:AAL29318.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 23..201
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAL29318.1"
FT NON_TER 201
FT /evidence="ECO:0000313|EMBL:AAL29318.1"
SQ SEQUENCE 201 AA; 23575 MW; 5AEB487BE2CD4455 CRC64;
KQWPLTEEKI KALIEICTEL EKEGKISKIG PENPYNTPVF AIKKKDSTKW RKLVDFRELN
KRTQDFWEVQ LGIPHPSGLK KKKSVTVLDV GDAYFSVPLD EDFRKYTAFT IPSINNETPG
IRYQYNVLPQ GWKGSPAIFQ SSMTKILEPF RKQNPDIVIY QYMDDLYVGS DLEIGQHRTK
IEELRQHLLR WGFYTPDKKH Q
//
