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Database: UniProt
Entry: Q90627
LinkDB: Q90627
Original site: Q90627 
ID   TRY1_CHICK              Reviewed;         248 AA.
AC   Q90627;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   14-MAY-2014, entry version 91.
DE   RecName: Full=Trypsin I-P1;
DE            EC=3.4.21.4;
DE   Flags: Precursor;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia;
OC   Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=7733885;
RA   Wang K., Gan L., Lee I., Hood L.E.;
RT   "Isolation and characterization of the chicken trypsinogen gene
RT   family.";
RL   Biochem. J. 307:471-479(1995).
CC   -!- CATALYTIC ACTIVITY: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
CC   -!- COFACTOR: Binds 1 calcium ion per subunit (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- TISSUE SPECIFICITY: High levels are seen in the pancreas while
CC       lower levels are found in the liver, spleen and thymus.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
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DR   EMBL; U15155; AAA79912.1; -; mRNA.
DR   PIR; S55067; S55067.
DR   RefSeq; NP_990716.1; NM_205385.1.
DR   UniGene; Gga.4442; -.
DR   UniGene; Gga.51254; -.
DR   ProteinModelPortal; Q90627; -.
DR   SMR; Q90627; 26-248.
DR   STRING; 9031.ENSGALP00000016613; -.
DR   PaxDb; Q90627; -.
DR   GeneID; 396345; -.
DR   KEGG; gga:396345; -.
DR   CTD; 5646; -.
DR   eggNOG; COG5640; -.
DR   HOGENOM; HOG000251820; -.
DR   HOVERGEN; HBG013304; -.
DR   InParanoid; Q90627; -.
DR   KO; K01312; -.
DR   PhylomeDB; Q90627; -.
DR   NextBio; 20816393; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   InterPro; IPR001254; Peptidase_S1.
DR   InterPro; IPR018114; Peptidase_S1_AS.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR009003; Trypsin-like_Pept_dom.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Digestion; Disulfide bond; Hydrolase;
KW   Metal-binding; Protease; Reference proteome; Secreted;
KW   Serine protease; Signal; Zymogen.
FT   SIGNAL        1     15       By similarity.
FT   PROPEP       16     25       Activation peptide (By similarity).
FT                                /FTId=PRO_0000028219.
FT   CHAIN        26    248       Trypsin I-P1.
FT                                /FTId=PRO_0000028220.
FT   DOMAIN       26    246       Peptidase S1.
FT   ACT_SITE     65     65       Charge relay system (By similarity).
FT   ACT_SITE    109    109       Charge relay system (By similarity).
FT   ACT_SITE    202    202       Charge relay system (By similarity).
FT   METAL        77     77       Calcium (By similarity).
FT   METAL        79     79       Calcium; via carbonyl oxygen (By
FT                                similarity).
FT   METAL        87     87       Calcium (By similarity).
FT   SITE        196    196       Required for specificity (By similarity).
FT   DISULFID     32    162       By similarity.
FT   DISULFID     50     66       By similarity.
FT   DISULFID    134    235       By similarity.
FT   DISULFID    141    208       By similarity.
FT   DISULFID    173    187       By similarity.
FT   DISULFID    198    222       By similarity.
SQ   SEQUENCE   248 AA;  26070 MW;  C4CF589912B23D98 CRC64;
     MKFLVLVAFV GVTVAFPISD EDDDKIVGGY SCARSAAPYQ VSLNSGYHFC GGSLISSQWV
     LSAAHCYKSS IQVKLGEYNL AAQDGSEQTI SSSKVIRHSG YNANTLNNDI MLIKLSKAAT
     LNSYVNTVPL PTSCVTAGTT CLISGWGNTL SSGSLYPDVL QCLNAPVLSS SQCSSAYPGR
     ITSNMICIGY LNGGKDSCQG DSGGPVVCNG QLQGIVSWGI GCAQKGYPGV YTKVCNYVSW
     IKTTMSSN
//
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