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Database: UniProt
Entry: Q909D8_9HIV1
LinkDB: Q909D8_9HIV1
Original site: Q909D8_9HIV1 
ID   Q909D8_9HIV1            Unreviewed;       197 AA.
AC   Q909D8;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAL30200.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AAL30200.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAL30200.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAL30200.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=R47354/26.1.98 {ECO:0000313|EMBL:AAL30200.1};
RX   PubMed=11808753;
RA   Yerly S., Rickenbach M., Popescu M., Taffe P., Craig C., Perrin L.;
RT   "Drug resistance mutations in HIV-1-infected subjects during protease
RT   inhibitor-containing highly active antiretroviral therapy with nelfinavir
RT   or indinavir.";
RL   Antivir. Ther. 6:185-189(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
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DR   EMBL; AF408475; AAL30200.1; -; Genomic_RNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33064; POL PROTEIN; 1.
DR   PANTHER; PTHR33064:SF35; RIBONUCLEASE H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:AAL30200.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          16..197
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAL30200.1"
FT   NON_TER         197
FT                   /evidence="ECO:0000313|EMBL:AAL30200.1"
SQ   SEQUENCE   197 AA;  22990 MW;  A7B8E3186D97AB00 CRC64;
     EKIKALVEIC TEMEKEGKIS KIGPENPYNT PIFAIKKKDS TKWRKLVDFR ELNKKTQDFW
     EVQLGIPHPS GLKKKKSVTV LDVGDAYFSV PLDEDFRKYT AFTIPSINNE TPGIRYQYNV
     LPQGWKGSPA IFQSSMTKIL EPFRKQNPDM VIYQYMDDLY VGSDLEIEQH RAKIEELRQH
     LLXWGFTTPD KKHQKEP
//
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