ID Q90LD0_9HIV1 Unreviewed; 257 AA.
AC Q90LD0;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAK56717.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAK56717.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAK56717.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAK56717.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12441083; DOI=10.1006/viro.2002.1621;
RA Izopet J., Cazabat M., Pasquier C., Sandres-Saune K., Bonnet E.,
RA Marchou B., Massip P., Puel J.;
RT "Evolution of total and integrated HIV-1 DNA and change in DNA sequences in
RT patients with sustained plasma virus suppression.";
RL Virology 302:393-404(2002).
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DR EMBL; AY029972; AAK56717.1; -; Genomic_DNA.
DR PIR; A47330; A47330.
DR PIR; B47330; B47330.
DR PIR; C47330; C47330.
DR PIR; D47330; D47330.
DR PIR; F47330; F47330.
DR PIR; S32058; S32058.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:AAK56717.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 47..237
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAK56717.1"
FT NON_TER 257
FT /evidence="ECO:0000313|EMBL:AAK56717.1"
SQ SEQUENCE 257 AA; 30036 MW; F8CD226E0B11043E CRC64;
AYFPISPIET VPVKLKPGMD GPKVKQWPLT EEKIKALVEI CTEMEKEGKI SKIGPENPYN
TPVFAIKKKN STRWRKLVDF RELNKRTQDF WEVQLGIPHP AGLKKKRSVT VLDVGDAYFS
VPLDKDFRKY TAFTIPSTNN ETPGIRYQYN VLPQGWKGSP AIFQSSMTKI LEPFREQNPD
IVIYQYMDDL YVGSDLEIGQ HRTKIEELRQ HLLRWGFFTP DEKHQKEPPF LWMGYELHPD
KWTVQPIKLP EKDSWTV
//
