ID JAG1A_DANRE Reviewed; 1242 AA.
AC Q90Y57;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-APR-2013, entry version 97.
DE RecName: Full=Protein jagged-1a;
DE Short=Jagged1;
DE Short=Jagged1a;
DE Flags: Precursor;
GN Name=jag1a; Synonyms=jag1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Oda T., Chandrasekharappa S.C.;
RT "Isolation, characterization and expression analysis of zebrafish
RT Jagged genes.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ligand for multiple Notch receptors and involved in the
CC mediation of Notch signaling (By similarity). Seems to be involved
CC in cell-fate decisions.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC protein (By similarity).
CC -!- SIMILARITY: Contains 1 DSL domain.
CC -!- SIMILARITY: Contains 17 EGF-like domains.
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DR EMBL; AF229448; AAL08213.1; -; mRNA.
DR IPI; IPI00505144; -.
DR RefSeq; NP_571936.1; NM_131861.1.
DR UniGene; Dr.83677; -.
DR ProteinModelPortal; Q90Y57; -.
DR SMR; Q90Y57; 187-335.
DR GeneID; 140421; -.
DR KEGG; dre:140421; -.
DR CTD; 140421; -.
DR ZFIN; ZDB-GENE-011128-2; jag1a.
DR eggNOG; NOG12793; -.
DR HOVERGEN; HBG031645; -.
DR InParanoid; Q90Y57; -.
DR KO; K06052; -.
DR OrthoDB; EOG4H729Q; -.
DR NextBio; 20796975; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR000742; EG-like_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_C.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 11.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 9.
DR SMART; SM00214; VWC; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 16.
DR PROSITE; PS01186; EGF_2; 12.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 8.
PE 2: Evidence at transcript level;
KW Calcium; Complete proteome; Developmental protein; Disulfide bond;
KW EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway;
KW Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1 28 Potential.
FT CHAIN 29 1242 Protein jagged-1a.
FT /FTId=PRO_0000007628.
FT TOPO_DOM 29 1070 Extracellular (Potential).
FT TRANSMEM 1071 1095 Helical; (Potential).
FT TOPO_DOM 1096 1242 Cytoplasmic (Potential).
FT DOMAIN 186 230 DSL.
FT DOMAIN 231 264 EGF-like 1.
FT DOMAIN 265 295 EGF-like 2; atypical.
FT DOMAIN 297 335 EGF-like 3.
FT DOMAIN 337 373 EGF-like 4.
FT DOMAIN 375 411 EGF-like 5; calcium-binding (Potential).
FT DOMAIN 413 449 EGF-like 6; calcium-binding (Potential).
FT DOMAIN 451 486 EGF-like 7; calcium-binding (Potential).
FT DOMAIN 488 524 EGF-like 8; calcium-binding (Potential).
FT DOMAIN 526 562 EGF-like 9.
FT DOMAIN 575 630 EGF-like 10.
FT DOMAIN 632 668 EGF-like 11; calcium-binding (Potential).
FT DOMAIN 670 706 EGF-like 12; calcium-binding (Potential).
FT DOMAIN 708 744 EGF-like 13.
FT DOMAIN 747 783 EGF-like 14.
FT DOMAIN 785 821 EGF-like 15; calcium-binding (Potential).
FT DOMAIN 823 859 EGF-like 16; calcium-binding (Potential).
FT DOMAIN 917 959 EGF-like 17.
FT CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 385 385 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 560 560 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 748 748 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 960 960 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 991 991 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 1046 1046 N-linked (GlcNAc...) (Potential).
FT DISULFID 188 197 By similarity.
FT DISULFID 201 213 By similarity.
FT DISULFID 221 230 By similarity.
FT DISULFID 235 246 By similarity.
FT DISULFID 239 252 By similarity.
FT DISULFID 254 263 By similarity.
FT DISULFID 266 277 By similarity.
FT DISULFID 272 283 By similarity.
FT DISULFID 285 294 By similarity.
FT DISULFID 301 313 By similarity.
FT DISULFID 307 323 By similarity.
FT DISULFID 325 334 By similarity.
FT DISULFID 341 352 By similarity.
FT DISULFID 346 361 By similarity.
FT DISULFID 363 372 By similarity.
FT DISULFID 379 390 By similarity.
FT DISULFID 384 399 By similarity.
FT DISULFID 401 410 By similarity.
FT DISULFID 417 428 By similarity.
FT DISULFID 422 437 By similarity.
FT DISULFID 439 448 By similarity.
FT DISULFID 455 465 By similarity.
FT DISULFID 459 474 By similarity.
FT DISULFID 476 485 By similarity.
FT DISULFID 492 503 By similarity.
FT DISULFID 497 512 By similarity.
FT DISULFID 514 523 By similarity.
FT DISULFID 530 541 By similarity.
FT DISULFID 535 550 By similarity.
FT DISULFID 552 561 By similarity.
FT DISULFID 600 618 By similarity.
FT DISULFID 620 629 By similarity.
FT DISULFID 636 647 By similarity.
FT DISULFID 641 656 By similarity.
FT DISULFID 658 667 By similarity.
FT DISULFID 674 685 By similarity.
FT DISULFID 679 694 By similarity.
FT DISULFID 696 705 By similarity.
FT DISULFID 712 723 By similarity.
FT DISULFID 717 732 By similarity.
FT DISULFID 734 743 By similarity.
FT DISULFID 751 762 By similarity.
FT DISULFID 756 771 By similarity.
FT DISULFID 773 782 By similarity.
FT DISULFID 789 800 By similarity.
FT DISULFID 794 809 By similarity.
FT DISULFID 811 820 By similarity.
FT DISULFID 827 838 By similarity.
FT DISULFID 832 847 By similarity.
FT DISULFID 849 858 By similarity.
SQ SEQUENCE 1242 AA; 135343 MW; 59557A4B7F052860 CRC64;
MILRPSATFA ALSAHVLLRC LWMRVCEASG HFEMQVLSMQ NVNGELQSGA CCDGARDPAE
RSCAADQCDT FFRVCLKEYQ SRVSSGGPCS YGSGSTPVIG GNTFSVKPLD QTNDKTRIVL
PFSFAWPRSY TLIVEALDFN NDSSTGSING QVIEKAVQSG MINPNRQWQV LKHNGPVAQF
QYQIRVTCDE HYFGFGCNKF CRPRDDFFGH YTCDHNGNKT CLEGWAGPEC NTAICKQGCS
IEHGSCKVPG NCRCLYGWQG EYCDQCIPHP GCVHGTCIEP WQCLCDTNWG GQLCDKDLNT
CGTLQPCLNG GTCSNTGPDK YHCACPDGYS GQNCERADNA CLSEPCLNGG LCVESSLGFE
CQCAAGWTGP SCNINEDDCS PNPCNHSGVC VDLVDGFKCI CPVQWTGKTC LIDANECEES
PCVNAHSCRN LIGGYFCECL PGWTGQNCDI NVNDCHGQCL NGGLCKDLVN GYRCVCAAGF
AGDRCERDVD ECASRPCLNG GRCQDTLNGF QCLCPPGFSG ATCQLDLDYC ESGPCQNGAQ
CFSLASDYYC KCPEDYEGKN CSQLKDHCLI TPCQVIDSCT VAVVSNSTPG GLRLISSSVC
GPHGRCRSHS HAGGHFSCDC QDGFTGTYCH ENINDCESSP CLSGGTCIDK INAYQCICAD
GWEGPNCETN IDDCRTNPCR DRGVCRDLVN DFYCECENGW KGKTCHSRES QCDEDTCNNG
GTCSDEGDSF KCLCSPGWEG ATCNIAKNSS CLPNPCENGA TCVVTGDGFT CVCKEGWEGP
TCSQNSNDCN PQPCYNSGTC VDGDNWYRCE CASGFAGPDC RININECQSS PCAFGSTCVD
EINGYRCLCP PGRTGPRCQE VTGRPCVIGG RIAVDGAKWA EDCNTCYCHK GIVTCTKLFC
GPKACRMLGS GRGDCPTGQL CVPVRDEQCF VKPCSSQGEC WSAHRPAVRT HCQPDSHCAN
VTFTFNKDTM PQGVTVEQVC RELRHLYVTK NVTSEFSISV SCELSSAASN EIHVAIHVTE
NGIHGRVPVK EITDNIIDLV SKHSANSSVI GSIAEVRVQR KQPQNPNVDY MVPLLVSVVT
AIWVLALASV FLWCIRHHRK QSSSATAINP TSPFSTPEEN TANNAREHLN QIKNHIEKNA
SNGSLPGKEL HCDDKNTVNA KIRTQFPESD ASRRLQKTRF PHQPAYMLVD RDDRLSSNGT
DIKKHPQWTN KRDNRDLESQ HRVPDSQHRD SQHSLQKMEY IV
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