ID Q910P8_POVJC Unreviewed; 688 AA.
AC Q910P8; Q6L819;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 138.
DE RecName: Full=Large T antigen {ECO:0000256|ARBA:ARBA00018805};
OS JC polyomavirus (JCPyV) (JCV).
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Sepolyvirales; Polyomaviridae; Betapolyomavirus;
OC Betapolyomavirus secuhominis.
OX NCBI_TaxID=10632 {ECO:0000313|EMBL:BAB68906.1, ECO:0000313|Proteomes:UP000162736};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAK70271.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=403 {ECO:0000313|EMBL:AAK70271.1}, 404
RC {ECO:0000313|EMBL:AAK70277.1}, 406 {ECO:0000313|EMBL:AAK70289.1}, and
RC 407 {ECO:0000313|EMBL:AAK70295.1};
RA Stoner G.L., Jobes D.V., Ryschkewitsch C.F., Fernandez Cobo M.;
RT "Evolutionary analysis of the human polyomavirus JC.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000105801, ECO:0000313|Proteomes:UP000138853}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11847555;
RA Sugimoto C., Hasegawa M., Kato A., Zheng H.Y., Ebihara H., Taguchi F.,
RA Kitamura T., Yogo Y.;
RT "Evolution of human Polyomavirus JC: implications for the population
RT history of humans.";
RL J. Mol. Evol. 54:285-297(2002).
RN [3] {ECO:0000313|EMBL:BAD21278.2, ECO:0000313|Proteomes:UP000143549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FL-8 {ECO:0000313|EMBL:BAD21278.2};
RX PubMed=15778974; DOI=10.1002/ajpa.20189;
RA Ikegaya H., Zheng H., Saukko P.J., Varesmaa-Korhonen L., Hovi T.,
RA Vesikari T., Suganami H., Takasaka T., Sugimoto C., Ohasi Y., Kitamura T.,
RA Yogo Y.;
RT "Genetic diversity of JC virus in the Saami and the Finns: implications for
RT their population history.";
RL Am. J. Phys. Anthropol. 128:185-193(2005).
RN [4] {ECO:0000313|EMBL:BAD21278.2, ECO:0000313|Proteomes:UP000143549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FL-8 {ECO:0000313|EMBL:BAD21278.2};
RX PubMed=18718622; DOI=10.1016/j.virol.2008.07.016;
RA Yogo Y., Zhong S., Shibuya A., Kitamura T., Homma Y.;
RT "Transcriptional control region rearrangements associated with the
RT evolution of JC polyomavirus.";
RL Virology 380:118-123(2008).
RN [5] {ECO:0000313|EMBL:ASV51785.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=#7 {ECO:0000313|EMBL:ASV51785.1}, and #8
RC {ECO:0000313|EMBL:ASV51791.1};
RX PubMed=28968776; DOI=10.1093/infdis/jix435;
RA Seppala H.M., Helantera I.T., Laine P.K.S., Lautenschlager I.T.,
RA Paulin L.G., Jahnukainen T.J., Auvinen P.O.V., Auvinen E.;
RT "Archetype JC Polyomavirus (JCPyV) Prevails in a Rare Case of JCPyV
RT Nephropathy and in Stable Renal Transplant Recipients With JCPyV Viruria.";
RL J. Infect. Dis. 216:981-989(2017).
RN [6] {ECO:0000313|EMBL:ASV51785.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=#7 {ECO:0000313|EMBL:ASV51785.1}, and #8
RC {ECO:0000313|EMBL:ASV51791.1};
RA de Groot N.N.;
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QTJ15181.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UJC077 {ECO:0000313|EMBL:QTJ15181.1}, and UJC295
RC {ECO:0000313|EMBL:QTJ15217.1};
RA Addetia A., Phung Q., Greninger A.;
RT "Defective polyomavirus genomes in clinical urine samples.";
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AF281609; AAK70271.1; -; Genomic_DNA.
DR EMBL; AF281610; AAK70277.1; -; Genomic_DNA.
DR EMBL; AF281612; AAK70289.1; -; Genomic_DNA.
DR EMBL; AF281613; AAK70295.1; -; Genomic_DNA.
DR EMBL; MF662186; ASV51785.1; -; Genomic_DNA.
DR EMBL; MF662187; ASV51791.1; -; Genomic_DNA.
DR EMBL; MF662205; ASV51899.1; -; Genomic_DNA.
DR EMBL; MF662206; ASV51905.1; -; Genomic_DNA.
DR EMBL; MF662207; ASV51911.1; -; Genomic_DNA.
DR EMBL; MF662208; ASV51917.1; -; Genomic_DNA.
DR EMBL; AB048563; BAB68882.1; -; Genomic_DNA.
DR EMBL; AB048564; BAB68888.1; -; Genomic_DNA.
DR EMBL; AB048565; BAB68894.1; -; Genomic_DNA.
DR EMBL; AB048567; BAB68906.1; -; Genomic_DNA.
DR EMBL; AB127350; BAD21278.2; -; Genomic_DNA.
DR EMBL; MW587999; QTJ15181.1; -; Genomic_DNA.
DR EMBL; MW588005; QTJ15217.1; -; Genomic_DNA.
DR SMR; Q910P8; -.
DR Proteomes; UP000105801; Genome.
DR Proteomes; UP000138853; Genome.
DR Proteomes; UP000143549; Genome.
DR Proteomes; UP000162736; Genome.
DR Proteomes; UP000171785; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039576; P:disruption by virus of host JAK-STAT cascade via inhibition of JAK1 activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039645; P:perturbation by virus of host G1/S transition checkpoint; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 3.40.1310.20; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.20.1050.70; Large T antigen, SV40, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.510; Zinc finger, large T-antigen D1 domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR016392; Lg_T_Ag_polyomavir.
DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003133; T_Ag_DNA-bd.
DR InterPro; IPR017910; Znf_lg_T-Ag_D1-typ.
DR InterPro; IPR037102; Znf_lg_T-Ag_D1_dom_sf.
DR Pfam; PF06431; Polyoma_lg_T_C; 1.
DR Pfam; PF02217; T_Ag_DNA_bind; 1.
DR PIRSF; PIRSF003368; Large_T_antigen_polyomaV; 1.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF55464; Origin of replication-binding domain, RBD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51206; SF3_HELICASE_1; 1.
DR PROSITE; PS51287; T_AG_OBD; 1.
DR PROSITE; PS51341; ZF_LTAG_D1; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00620}; Early protein {ECO:0000256|ARBA:ARBA00022518};
KW G1/S host cell cycle checkpoint dysregulation by virus
KW {ECO:0000256|ARBA:ARBA00023309};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Inhibition of host JAK1 by virus {ECO:0000256|ARBA:ARBA00023318};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00022830};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00671}.
FT DOMAIN 12..75
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT DOMAIN 140..255
FT /note="T-ag OBD"
FT /evidence="ECO:0000259|PROSITE:PS51287"
FT DOMAIN 266..358
FT /note="T-ag D1-type"
FT /evidence="ECO:0000259|PROSITE:PS51341"
FT DOMAIN 401..561
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51206"
FT DNA_BIND 140..255
FT /note="T-ag OBD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00620"
FT REGION 115..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 79341 MW; 649FECF9119057F9 CRC64;
MDKVLNREES MELMDLLGLD RSAWGNIPIM RKAYLKKCKE LHPDKGGDED KMKRMNFLYK
KMEQGVKVAH QPDFGTWNSS EVPTYGTDEW ESWWNTFNEK WDEDLFCHEE MFASDDENTG
SQHSTPPKKK KKVEDPKDFP VDLHAFLSQA VFSNRTVASF AVYTTKEKAQ ILYKKLMEKY
SVTFISRHGF GGHNILFFLT PHRHRVSAIN NYCQKLCTFS FLICKGVNKE YLFYSALCRQ
PYAVVEESIQ GGLKEHDFNP EEPEETKQVS WKLVTQYALE TKCEDVFLLM GMYLDFQENP
QQCKKCEKKD QPNHFNHHEK HYYNAQIFAD SKNQKSICQQ AVDTVAAKQR VDSIHMTREE
MLVERFNFLL DKMDLIFGAH GNAVLEQYMA GVAWIHCLLP QMDTVIYDFL KCIVLNIPKK
RYWLFKGPID SGKTTLAAAL LDLCGGKSLN VNMPLERLNF ELGVGIDQFM VVFEDVKGTG
AESRDLPSGH GISNLDCLRD YLDGSVKVNL ERKHQNKRTQ VFPPGIVTMN EYSVPRTLQA
RFVRQIDFRP KAYLRKSLSC SEYLLEKRIL QSGMTLLLLL IWFRPVADFA AAIHERIVQW
KERLDLEISM YTFSTMKANV GMGRPILDFP REEDSEAEDS GHGSSTESQS QCFSQVSEAS
GADTQENCTY HICKGFQCFK KPKTPPPK
//
