ID Q91476_SALSA Unreviewed; 117 AA.
AC Q91476;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Insulin-like growth factor I {ECO:0000313|EMBL:AAA18212.1};
DE Flags: Fragment;
GN Name=insulin-like growth factor I {ECO:0000313|EMBL:AAA18212.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:AAA18212.1};
RN [1] {ECO:0000313|EMBL:AAA18212.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:AAA18212.1};
RX PubMed=1406698; DOI=10.1210/me.6.8.1202;
RA Duguay S.J., Park L.K., Samadpour M., Dickhoff W.W.;
RT "Nucleotide sequence and tissue distribution of three insulin-like growth
RT factor I prohormones in salmon.";
RL Mol. Endocrinol. 6:1202-1210(1992).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; M81904; AAA18212.1; -; mRNA.
DR AlphaFoldDB; Q91476; -.
DR SMR; Q91476; -.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0042539; P:hypotonic salinity response; IDA:AgBase.
DR GO; GO:0032355; P:response to estradiol; IDA:AgBase.
DR GO; GO:0014070; P:response to organic cyclic compound; IDA:AgBase.
DR GO; GO:0042594; P:response to starvation; IDA:AgBase.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46845:SF3; INSULIN-LIKE GROWTH FACTOR 1; 1.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..117
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004318651"
FT DOMAIN 21..79
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT DISULFID 24..66
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 36..79
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 65..70
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT NON_TER 117
FT /evidence="ECO:0000313|EMBL:AAA18212.1"
SQ SEQUENCE 117 AA; 12867 MW; A97666EE2F526EAC CRC64;
TLSLLLCVLT LTSAATGAGP ETLCGAELVD TLQFVCGERG FYFSKPTGYG PSSRRSHNRG
IVDECCFQSC ELRRLEMYCA PVKSGKAARS VRAQRHTDMP RTPKNLYLGI VTHLARR
//
